Acute Cardiovascular Events Triggered by COVID-19-Related Stress

NCT ID: NCT04368637

Last Updated: 2020-05-05

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-05-03
• Study Completion Date: 2020-08-30

Brief Summary

The current COVID19 pandemic has afflicted almost the whole globe. The stress related to the pandemic, not the direct virus-related injury, can be potentially associated with acute cardiovascular events due to a large list of physical and psychosocial stresses.

This study is a cross sectional study that will enroll patients evaluated during the COVID19 pandemic period for acute cardiovascular events.

Detailed Description

The onset of acute myocardial infarction (AMI) is a complex interplay of internal circadian factors and external physical and emotional triggers. These interactions may lead to rupture of an often non-occlusive vulnerable atherosclerotic coronary plaque with subsequent formation of an occlusive thrombus. Physical and emotional stresses are important triggers of acute cardiovascular events including AMI. Triggering events, internal changes, and external factors vary among different geographical, environmental, and ethnic regions. Life-style changes, pharmacotherapy, and psychological interventions may potentially modify the response to, and protect against the effects of triggering events. Certain times in the life span of different communities all around the world are prone to natural and man-made disasters that, not only have direct negative impact on human lives and state-resources, but also have indirect impact on triggering acute cardiovascular events during the time of the disaster and the period immediately after. For example, earthquakes, wars, and terrorist attacks, in addition to direct human life loss and destruction of communities, have bees associated with a surge in the number of acute MI, sudden cardiac death, ventricular tachy-arrhythmia and implantable cardiovertor defibrillators (ICD) discharges.

The current COVID-19 pandemic has afflicted almost the whole globe. The virus can directly attack the myocyte and cause various degrees of cardiac damage and cardiovascular clinical entities. However, the stress related to the pandemic, not the direct virus-related injury, can be potentially associated with acute cardiovascular events due to a large list of physical and psycho-social stresses such as extreme physical effort, lock down, anger, fear, financial stress, sorrow, death of a significant person..etc.

This study is a cross sectional study that will enroll patients evaluated during the COVID-19 pandemic period for acute cardiovascular events not directory related to the virus infectivity, who voice certain and specific trigger(s) related to the pandemic impact on social life and physical activity.

Conditions

Acute Myocardial Infarction; Ventricular Tachycardia; Sudden Cardiac Death; Stroke, Acute

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Age >18 years.
• Acute MI (STEMI and NSTEMI).
• Sudden cardiac death
• Ventricular tachycardia
• ICD shocks.
• Stressful trigger prior to the cardiovascular event

Exclusion Criteria

• COVID-19 infection.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jordan Collaborating Cardiology Group

OTHER

Sponsor Role: lead

Responsible Party

Ayman J. Hammoudeh, MD, FACC

Interventional Cardiologist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ayman J Hammoudeh, MD, FACC

Role: STUDY_CHAIR

JCC Group

Locations

Istishari Hospital

Amman, , Jordan

Site Status: RECRUITING

Abdelhadi Hospital

Amman, , Jordan

Site Status: RECRUITING

Farah Hospital

Amman, , Jordan

Site Status: RECRUITING

Jordan Hospital

Amman, , Jordan

Site Status: RECRUITING

Specialty Hospital

Amman, , Jordan

Site Status: RECRUITING

Countries

Jordan

Central Contacts

Ayman J Hammoudeh, MD, FACC

Role: CONTACT

hammoudeh_ayman@yahoo.com

0096265001000

Ayadeh Madanat, MD

Role: CONTACT

ayadeh.madanat@gmail.com

00962796224241

Facility Contacts

Ayman Hammoudeh, MD, FACC

Role: primary

a.hammoudeh@istisharihospital.com

0096265001000

Walaa Abu Moghli, PharmD

Role: backup

a.hammoudeh@istisharihospital.com

0096265001000

Zeina Abu Orabi, MD

Role: primary

Hadi Abu hantash, MD, FACC

Role: primary

Imad Alhaddad, MD

Role: primary

alhaddad63@gmail.com

00962795303502

Mahmoud Izraiq Mahmoud Izraiq, MD

Role: primary

Other Identifiers

JCCG.JoCORE.4.4040

Identifier Type: -

Identifier Source: org_study_id