SARS-CoV-2 Associated Respiratory Failure Recovery (COVID-19 CAir)

NCT ID: NCT04365595

Last Updated: 2021-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

58 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-03

Study Completion Date

2021-02-17

Brief Summary

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the current pandemic of coronavirus disease (COVID-19) that can lead to respiratory failure requiring oxygen therapy. Some patients develop acute respiratory distress syndrome (ARDS) and may die despite intensive care therapy. Currently it is unknown a) how fast patients recover after being discharged from hospital and b) what underlying predictors may influence recovery.

Detailed Description

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Study aims:

* To evaluate subjective and objective recovery after discharge from hospital in patients with respiratory failure due to COVID-19.
* To identify risk factors for COVID-19 associated respiratory failure and prolonged recovery

Conditions

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SARS-CoV 2 COVID

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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SARS-CoV-2 associated respiratory failure

Participants will receive a daily HrQoL questionnaire on their personal smartphone using the docdok health application during 3 months. A selection of participants will furthermore receive a custom-built home disease monitoring device during 1 month. Both procedures start at least 4 weeks after hospital discharge.

Questionnaires, spirometry

Intervention Type OTHER

Questionnaires targeting health-related quality-of-life, symptoms, anxiety and depression

Interventions

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Questionnaires, spirometry

Questionnaires targeting health-related quality-of-life, symptoms, anxiety and depression

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* hospitalization at University Hospital Zurich due to COVID-19 infection
* hospital discharge max. 4 weeks ago
* requiring supplemental oxygen

Exclusion Criteria

* \<18 years
* non-German speaking
* no smartphone access
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christian F Clarenbach, MD

Role: PRINCIPAL_INVESTIGATOR

University of Zurich

Locations

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University Hospital Zurich

Zurich, , Switzerland

Site Status

Countries

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Switzerland

References

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Kohlbrenner D, Kuhn M, Stussi-Helbling M, Nordmann Y, Spielmanns M, Clarenbach CF. Longitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study. Front Rehabil Sci. 2021 Nov 24;2:777396. doi: 10.3389/fresc.2021.777396. eCollection 2021.

Reference Type DERIVED
PMID: 36188784 (View on PubMed)

Other Identifiers

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2020-00745

Identifier Type: -

Identifier Source: org_study_id

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