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(KIWI) Speeding up a Slow Protein for Muscle Mass With Hay Kiwifruit

NCT ID: NCT04356573

Last Updated: 2021-11-04

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-07-01

Study Completion Date

2018-11-20

Brief Summary

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The specific hypothesis is that the consumption of 2 Hayward green kiwifruit (containing actinidin protease) prior to 100g of ground beef will increase the rate of protein digestion from the beef in the elderly, leading to an increased uptake of the essential amino acids. Furthermore, this increased essential amino acid availability will produce a greater postprandial net anabolic protein response, as well as increased fractional synthetic rates of muscle proteins.

Detailed Description

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The specific hypothesis is that the consumption of 2 Hayward green kiwifruit (containing actinidin protease) prior to 100g of ground beef will increase the rate of protein digestion from the beef in the elderly, leading to an increased uptake of the essential amino acids. Furthermore, this increased essential amino acid availability will produce a greater postprandial net anabolic protein response, as well as increased fractional synthetic rates of muscle proteins.

To test this hypothesis, the investigators will use a double-blinded crossover design involving two intervention arms; in both arms 100g of ground beef (cooked weight) will be consumed following either 2 Hayward green kiwifruit (containing actinidin protease) or 2 Hort16A Gold kiwifruit (devoid of actinidin protease) by elderly subjects.

Conditions

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Metabolism Protein

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Subjects crossed over between ingesting 2 different types of kiwifruit for 2 weeks prior to each stable isotope metabolic study.
Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Biological samples were coded and code list password protected until all data was analyzed.

Study Groups

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Gold Kiwifruit First, then Green Hayward Kiwifruit

Subjects first ate 2 gold kiwifruit with midday meal for 2 weeks before crossing over to the green Hayward kiwifruit intervention

Group Type PLACEBO_COMPARATOR

Green Hayward Kiwifruit first, then Gold Kiwifruit

Intervention Type DIETARY_SUPPLEMENT

Subjects ate 2 peeled green kiwifruit with their midday meal for 2 weeks prior to testing.

Gold Kiwifruit First, then Green Hayward Kiwifruit

Intervention Type DIETARY_SUPPLEMENT

Subjects ate 2 peeled gold kiwifruit with their midday meal for 2 weeks prior to testing.

Green Hayward Kiwifruit first, then Gold Kiwifruit

Subjects first ate 2 green Hayward kiwifruit with midday meal for 2 weeks before crossing over to the gold kiwifruit intervention

Group Type ACTIVE_COMPARATOR

Green Hayward Kiwifruit first, then Gold Kiwifruit

Intervention Type DIETARY_SUPPLEMENT

Subjects ate 2 peeled green kiwifruit with their midday meal for 2 weeks prior to testing.

Gold Kiwifruit First, then Green Hayward Kiwifruit

Intervention Type DIETARY_SUPPLEMENT

Subjects ate 2 peeled gold kiwifruit with their midday meal for 2 weeks prior to testing.

Interventions

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Green Hayward Kiwifruit first, then Gold Kiwifruit

Subjects ate 2 peeled green kiwifruit with their midday meal for 2 weeks prior to testing.

Intervention Type DIETARY_SUPPLEMENT

Gold Kiwifruit First, then Green Hayward Kiwifruit

Subjects ate 2 peeled gold kiwifruit with their midday meal for 2 weeks prior to testing.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* men and women ages 60-85 inclusive.

Exclusion Criteria

* Inability to chew meats or difficulty swallowing solid foods
* History of diabetes
* History of malignancy in the 6 months prior to enrolment
* History of gastrointestinal reduction or bypass surgery (Lapband, etc)
* History of a chronic inflammatory condition or disease (Lupus, HIV'AIDS, etc)
* History of chronic kidney disease or currently requiring dialysis.
* Allergy to beef or kiwifruit
* Subjects who do not or will not eat animal proteins
* Subjects who cannot refrain from consuming protein or amino acid supplements during their participation in this study
* Subjects who report regular resistance exercise (more than once per week)
* Hemoglobin less than 9.5mg/dL at the screening visit
* Platelets less than \<150,000 at the screening visit
* Subjects who are not willing or able to suspend aspirin for several days prior to their muscle biopsies.
* Subjects who have been prescribed a blood-thinning medication (Coumadin, lovenox, heparin, Plavix, etc).
* Concomitant use of corticosteroids (ingestion, injection or transdermal)
* Any other disease or condition that would place the subject at increased risk of harm if they were to participate, at the discretion of the study physician
Minimum Eligible Age

60 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Arkansas

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Arny A Ferrando, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

UAMS professor

Locations

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UAMS Center on Aging

Little Rock, Arkansas, United States

Site Status

Countries

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United States

References

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Park S, Church DD, Starck C, Schutzler SE, Azhar G, Kim IY, Ferrando AA, Moughan PJ, Wolfe RR. The impact of Hayward green kiwifruit on dietary protein digestion and protein metabolism. Eur J Nutr. 2021 Mar;60(2):1141-1148. doi: 10.1007/s00394-020-02363-5. Epub 2020 Sep 24.

Reference Type DERIVED
PMID: 32970234 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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206814

Identifier Type: -

Identifier Source: org_study_id