Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
132 participants
INTERVENTIONAL
2020-06-01
2021-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Minimal Stimulation Group
Minimal dose stimulation ovarian induction protocol given to poor responders, involving letrozole, low dose recombinant FSH and GnRH antagonist
Minimal stimulation protocol
Letrozole, Recombinant FSH, GnRH antagonist
IVF/ICSI cycle
Involving ovum pickup and embryo transfer
Microflare Group
Microflare ovarian induction protocol given to poor responders, involving OCP, GnRH agonist, high dose recombinant FSH
Microflare protocol
OCP, GnRH agonist, Recombinant FSH
IVF/ICSI cycle
Involving ovum pickup and embryo transfer
Interventions
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Minimal stimulation protocol
Letrozole, Recombinant FSH, GnRH antagonist
Microflare protocol
OCP, GnRH agonist, Recombinant FSH
IVF/ICSI cycle
Involving ovum pickup and embryo transfer
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
1. Advanced maternal age
2. Previous poor ovarian response
3. Abnormal tests of ovarian reserve (AFC \< 5-7, AMH \<0.5-1.1 ng/ml)
Exclusion Criteria
2. baseline FSH \>15 mIU/ml
3. Previous ovarian surgery
4. Ovarian endometrioma
5. Uterine anomaly or myoma
6. Any medical disorder
7. Any hormonal disorder eg. hyperprolactinemia
8. BMI \> 30 kg/m2
9. Severe male factor
30 Years
43 Years
FEMALE
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Yasmin Ahmed Bassiouny
Assisstant Professor
Principal Investigators
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Sarwat Ahwany, MD
Role: STUDY_DIRECTOR
Cairo University
Locations
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IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini)
Cairo, , Egypt
Cairo University
Cairo, , Egypt
Countries
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Other Identifiers
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12020
Identifier Type: -
Identifier Source: org_study_id