Trial Outcomes & Findings for The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI (NCT NCT04316676)
NCT ID: NCT04316676
Last Updated: 2026-01-06
Results Overview
The absolute quantification of myocardial perfusion between CT-MPI and PET-MPI is compared. Myocardial perfusion is quantified using appropriate tracer kinetic models resulting myocardial blood flow mL/g/min.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
20 participants
Primary outcome timeframe
Day of PET-MPI Scan, and Day of CT-MPI and CT-FFR Scans (up to 90 days)
Results posted on
2026-01-06
Participant Flow
Participants were recruited from Emory University Hospital in Atlanta, Georgia, USA. Participant enrollment began June 16, 2021 and all follow-up assessments were completed by September 24, 2024.
Participant milestones
| Measure |
Three Imaging Techniques: PET-MPI, CT-MPI, and CCTA for CT-FFR Calculation
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
|
|---|---|
|
Overall Study
STARTED
|
20
|
|
Overall Study
COMPLETED
|
20
|
|
Overall Study
NOT COMPLETED
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI
Baseline characteristics by cohort
| Measure |
Three Imaging Techniques: PET-MPI, CT-MPI, and CT-FFR
n=20 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
|
|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=37 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
18 Participants
n=37 Participants
|
|
Age, Categorical
>=65 years
|
2 Participants
n=37 Participants
|
|
Age, Continuous
|
55.9 years
STANDARD_DEVIATION 9.0 • n=37 Participants
|
|
Sex: Female, Male
Female
|
14 Participants
n=37 Participants
|
|
Sex: Female, Male
Male
|
6 Participants
n=37 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
1 Participants
n=37 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
19 Participants
n=37 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=37 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=37 Participants
|
|
Race (NIH/OMB)
Asian
|
0 Participants
n=37 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=37 Participants
|
|
Race (NIH/OMB)
Black or African American
|
9 Participants
n=37 Participants
|
|
Race (NIH/OMB)
White
|
10 Participants
n=37 Participants
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=37 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=37 Participants
|
|
Region of Enrollment
United States
|
20 Participants
n=37 Participants
|
|
Body Mass Index (BMI)
|
34.9 kg/m^2
STANDARD_DEVIATION 8.3 • n=37 Participants
|
PRIMARY outcome
Timeframe: Day of PET-MPI Scan, and Day of CT-MPI and CT-FFR Scans (up to 90 days)Population: PET-MPI data were lost for two participants during an equipment move.
The absolute quantification of myocardial perfusion between CT-MPI and PET-MPI is compared. Myocardial perfusion is quantified using appropriate tracer kinetic models resulting myocardial blood flow mL/g/min.
Outcome measures
| Measure |
CT-MPI
n=20 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
For the CT-MPI, dynamic volume CT myocardial perfusion applying the "dynamic shuttle" mode is used to rapidly cover the entire cardiac anatomy during infusion of a contrast medium bolus for monitoring bolus passage through the left ventricular myocardium. This scan acquisition is performed during pharmacologically induced stress and during rest conditions. CT-MPI studies are contrast medium enhanced by an iodinated contrast agent. Pharmacological stress testing for the CT-MPI scan is performed with a single injection of 0.4 mg of regadenoson.
|
PET-MPI - Rest
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease (CAD), also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
PET-MPI - Stress
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
|---|---|---|---|
|
Myocardial Blood Flow
|
1.60 mL/g/min
Standard Deviation 0.43
|
0.96 mL/g/min
Standard Deviation 0.29
|
2.40 mL/g/min
Standard Deviation 1.09
|
PRIMARY outcome
Timeframe: Day of CT-MPI and CCTA scansPopulation: Only one participant met clinical guidelines for the calculation of CT-FFR by having intermediate stenosis. One participant had stenosis too high to calculate CT-FFR while the remaining 18 participants had too little stenosis for an informative calculation.
Coronary flow is measured using the CT-FFR calculation with the CCTA scans. CT-FFR measures blood flow through coronary arteries and is used clinically to quantify the severity of CAD to determine further interventions. CT-FFR is the ratio between the blood flow (BF) in a diseased artery and a normal artery. Clinically, the CT-FFR calculation is only useful in patients with intermediate stenosis because stenosis below intermediate results in a value that is near zero and the calculation cannot be performed when stenosis is complete. The normal range for CT-FFR is greater than 0.80, values of 0.76 to 0.80 are borderline while values of 0.75 or less are associated with a high likelihood of reduced blood flow (ischemia).
Outcome measures
| Measure |
CT-MPI
n=1 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
For the CT-MPI, dynamic volume CT myocardial perfusion applying the "dynamic shuttle" mode is used to rapidly cover the entire cardiac anatomy during infusion of a contrast medium bolus for monitoring bolus passage through the left ventricular myocardium. This scan acquisition is performed during pharmacologically induced stress and during rest conditions. CT-MPI studies are contrast medium enhanced by an iodinated contrast agent. Pharmacological stress testing for the CT-MPI scan is performed with a single injection of 0.4 mg of regadenoson.
|
PET-MPI - Rest
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease (CAD), also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
PET-MPI - Stress
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
|---|---|---|---|
|
Coronary Flow Per CT-FFR
|
1.29 ratio
|
—
|
—
|
PRIMARY outcome
Timeframe: Day 1 (day of scans)Population: This analysis includes participants with a PET-MPI result available. PET-MPI data were lost for two participants during an equipment move. Only one participant met clinical guidelines for the calculation of CT-FFR by having intermediate stenosis, however, the gold standard PET exam provided an incorrect diagnosis thus calculating sensitivity cannot correctly estimate the accuracy of CT-FFR.
The accuracy of detection of myocardial perfusion abnormalities is compared between PET-MPI, CT-MPI, CCTA, and CT-FFR approach. Diagnostic accuracy using CT-MPI, CCTA and CT-FFR is calculated as sensitivity (true positives) with PET as the reference standard.
Outcome measures
| Measure |
CT-MPI
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
For the CT-MPI, dynamic volume CT myocardial perfusion applying the "dynamic shuttle" mode is used to rapidly cover the entire cardiac anatomy during infusion of a contrast medium bolus for monitoring bolus passage through the left ventricular myocardium. This scan acquisition is performed during pharmacologically induced stress and during rest conditions. CT-MPI studies are contrast medium enhanced by an iodinated contrast agent. Pharmacological stress testing for the CT-MPI scan is performed with a single injection of 0.4 mg of regadenoson.
|
PET-MPI - Rest
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease (CAD), also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
PET-MPI - Stress
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
|---|---|---|---|
|
Sensitivity of Myocardial Perfusion Abnormalities Diagnosis
|
100 percentage of true postive cases
|
—
|
100 percentage of true postive cases
|
PRIMARY outcome
Timeframe: Day 1 (day of scans)Population: This analysis includes participants with a PET-MPI result available. PET-MPI data were lost for two participants during an equipment move. Only one participant met clinical guidelines for the calculation of CT-FFR by having intermediate stenosis, however, the gold standard PET exam provided an incorrect diagnosis thus calculating specificity cannot correctly estimate the accuracy of CT-FFR.
The accuracy of detection of myocardial perfusion abnormalities is compared between PET-MPI, CT-MPI, CCTA, and CT-FFR approach. Diagnostic accuracy using CT-MPI, CCTA and CT-FFR is calculated as specificity (true negatives) with PET as the reference standard.
Outcome measures
| Measure |
CT-MPI
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
For the CT-MPI, dynamic volume CT myocardial perfusion applying the "dynamic shuttle" mode is used to rapidly cover the entire cardiac anatomy during infusion of a contrast medium bolus for monitoring bolus passage through the left ventricular myocardium. This scan acquisition is performed during pharmacologically induced stress and during rest conditions. CT-MPI studies are contrast medium enhanced by an iodinated contrast agent. Pharmacological stress testing for the CT-MPI scan is performed with a single injection of 0.4 mg of regadenoson.
|
PET-MPI - Rest
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease (CAD), also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
PET-MPI - Stress
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
|---|---|---|---|
|
Specificity of Myocardial Perfusion Abnormalities Diagnosis
|
100 percentage of true negative cases
|
—
|
94 percentage of true negative cases
|
PRIMARY outcome
Timeframe: Day 1 (day of scans)Population: This analysis includes participants with a PET-MPI result available. PET-MPI data were lost for two participants during an equipment move.
The accuracy of detection of myocardial perfusion abnormalities is compared between PET-MPI, CT-MPI, CCTA, and CT-FFR approach. Diagnostic accuracy using CT-MPI, CCTA and CT-FFR is calculated as overall AUC with PET as the reference standard. The AUC examines the overall accuracy of a diagnostic test. Higher AUC indicates greater accuracy in detecting myocardial perfusion abnormalities with 1.0 being 100% accurate. An AUC value of 0.5 indicates that the test is as accurate as random chance.
Outcome measures
| Measure |
CT-MPI
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
For the CT-MPI, dynamic volume CT myocardial perfusion applying the "dynamic shuttle" mode is used to rapidly cover the entire cardiac anatomy during infusion of a contrast medium bolus for monitoring bolus passage through the left ventricular myocardium. This scan acquisition is performed during pharmacologically induced stress and during rest conditions. CT-MPI studies are contrast medium enhanced by an iodinated contrast agent. Pharmacological stress testing for the CT-MPI scan is performed with a single injection of 0.4 mg of regadenoson.
|
PET-MPI - Rest
n=1 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease (CAD), also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
PET-MPI - Stress
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
|---|---|---|---|
|
Area Under the Curve (AUC) for Detection of Myocardial Perfusion Abnormalities
|
1.00 probabliity of accurate detection
|
0 probabliity of accurate detection
|
0.97 probabliity of accurate detection
|
PRIMARY outcome
Timeframe: Day 1 (day of scans)Population: This analysis includes participants with a PET-MPI result available. PET-MPI data were lost for two participants during an equipment move.
The accuracy of detection of coronary stenosis is compared between PET-MPI, CT-MPI, and CCTA with CT-FFR approach. Diagnostic accuracy is calculated as sensitivity (true positives) with CCTA as the reference standard.
Outcome measures
| Measure |
CT-MPI
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
For the CT-MPI, dynamic volume CT myocardial perfusion applying the "dynamic shuttle" mode is used to rapidly cover the entire cardiac anatomy during infusion of a contrast medium bolus for monitoring bolus passage through the left ventricular myocardium. This scan acquisition is performed during pharmacologically induced stress and during rest conditions. CT-MPI studies are contrast medium enhanced by an iodinated contrast agent. Pharmacological stress testing for the CT-MPI scan is performed with a single injection of 0.4 mg of regadenoson.
|
PET-MPI - Rest
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease (CAD), also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
PET-MPI - Stress
n=1 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
|---|---|---|---|
|
Sensitivity of Coronary Stenosis Diagnosis
|
67 percentage of true postive cases
|
67 percentage of true postive cases
|
100 percentage of true postive cases
|
PRIMARY outcome
Timeframe: Day 1 (day of scans)Population: This analysis includes participants with a PET-MPI result available. PET-MPI data were lost for two participants during an equipment move. Specificity could not be calculated in the CCTA with CT-FFR Calculation study arm as there was not a participant negative for coronary stenosis per the reference standard.
The accuracy of detection of coronary stenosis is compared between PET-MPI, CT-MPI, and CCTA with CT-FFR approach. Diagnostic accuracy is calculated as specificity (true negatives) with CCTA as the reference standard.
Outcome measures
| Measure |
CT-MPI
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
For the CT-MPI, dynamic volume CT myocardial perfusion applying the "dynamic shuttle" mode is used to rapidly cover the entire cardiac anatomy during infusion of a contrast medium bolus for monitoring bolus passage through the left ventricular myocardium. This scan acquisition is performed during pharmacologically induced stress and during rest conditions. CT-MPI studies are contrast medium enhanced by an iodinated contrast agent. Pharmacological stress testing for the CT-MPI scan is performed with a single injection of 0.4 mg of regadenoson.
|
PET-MPI - Rest
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease (CAD), also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
PET-MPI - Stress
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
|---|---|---|---|
|
Specificity of Coronary Stenosis Detection
|
100 percentage of true negative cases
|
100 percentage of true negative cases
|
—
|
PRIMARY outcome
Timeframe: Day 1 (day of scans)Population: This analysis includes participants with a PET-MPI result available. PET-MPI data were lost for two participants during an equipment move.
The accuracy of detection of coronary stenosis is compared between PET-MPI, CT-MPI, and CCTA with CT-FFR approach. Diagnostic accuracy is calculated as overall AUC with CCTA as the reference standard. The AUC examines the overall accuracy of a diagnostic test. Higher AUC indicates greater accuracy in detecting coronary stenosis with 1.0 being 100% accurate. An AUC value of 0.5 indicates that the test is as accurate as random chance.
Outcome measures
| Measure |
CT-MPI
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
For the CT-MPI, dynamic volume CT myocardial perfusion applying the "dynamic shuttle" mode is used to rapidly cover the entire cardiac anatomy during infusion of a contrast medium bolus for monitoring bolus passage through the left ventricular myocardium. This scan acquisition is performed during pharmacologically induced stress and during rest conditions. CT-MPI studies are contrast medium enhanced by an iodinated contrast agent. Pharmacological stress testing for the CT-MPI scan is performed with a single injection of 0.4 mg of regadenoson.
|
PET-MPI - Rest
n=18 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease (CAD), also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
PET-MPI - Stress
n=1 Participants
Participants referred for a clinical positron emission tomography myocardial perfusion imaging (PET-MPI), the gold standard for evaluating patients with suspected coronary blockages or coronary artery disease, also attend a study visit where they have computed tomography (CT) myocardial perfusion imaging (CT-MPI) and coronary CT angiography for calculation of CT fractional flow reserve (CT-FFR) imaging performed for analysis of myocardial perfusion. The CT examinations are scheduled within 90 days of the standard clinical PET examination.
Patients with suspected CAD who are referred to a clinical PET-MPI undergo the standard clinical protocol applied in the Emory Nuclear Medicine department. PET-MPI is performed with stress and rest conditions.
|
|---|---|---|---|
|
Area Under the Curve for Detection of Coronary Stenosis
|
0.83 probabliity of accurate detection
|
0.83 probabliity of accurate detection
|
1 probabliity of accurate detection
|
Adverse Events
PET-MPI
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
CT-MPI
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
CCTA With CT-FFR Calculation
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place