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Acute Health Effects Due to Ultrafine Particles From Candles and Cooking

NCT ID: NCT04315740

Last Updated: 2020-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-01

Study Completion Date

2019-12-20

Brief Summary

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People spend up to 90% of their life indoor, and the way we live and behave in our homes has substantial effects on our health and well-being. Particle contamination is suggested to have substantial negative effects on health, with candles and cooking emitting the largest amount of particles, thus being the largest contributors to indoor air pollution.

The overall aim of the present project is to contribute to increased understanding of the association between indoor particulate air pollution and health and well-being.

Detailed Description

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Introduction: People spend up to 90% of their life indoor, and the way we live and behave in our homes has substantial effects on our health and well-being. Particle contamination is suggested to have substantial negative effects on health, with candles and cooking emitting the largest amount of particles, thus being the largest contributors to indoor air pollution. Little is known about the potential adverse health effects of candles and cooking, and people with asthma may be more susceptible.

Aim: To investigate local and systemic effects of short-term exposure to lit candles and cooking among young asthmatics.

Design: In a randomised double-blinded cross-over study non-smoking asthmatics (18-25 years) were exposed for five hours at three different exposure conditions separated by 14 days; A) clean filtered air, B) lit candles and C) cooking emissions under controlled environmental conditions.

Measurements: TSI P-TRAK Ultrafine Particle Counter was used for particle counts. Health effects, including lung function (FEV1/FVC) and fraction of exhaled nitric oxide (FeNO) were evaluated in relation to local and systemic effects prior to, right after and 24 h. after exposure.

Analysis: Mixed methods approach taking both time and exposure into account.

Conditions

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Candle Burning Cooking Lung Function Decreased DNA Damage Subjective Health Asthma

Keywords

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Particle contamination Indoor air Acute health effects RCT Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

A randomised double-blinded crossover study
Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors
The exposure was generated in small adjacent chamber and thereby led into the exposure chamber using a pipe connection and a small negative pressure. Thus, the exposure could not be observed.

Study Groups

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Clean Air

Just clean air - no exposure

Group Type SHAM_COMPARATOR

Clean Air

Intervention Type OTHER

Nothing but clean air

Cooking

Four ovens were frying pork - one at a time. When the first oven finished, the next oven started and so forth for approx. 7 hours.

Group Type EXPERIMENTAL

Particles from cooking

Intervention Type OTHER

Generating fine and ultrafine particles from frying pork in an oven

Candles

10 lit candles were placed at a table. Burning for approx. 7 hours with light ventilation.

Group Type EXPERIMENTAL

Particles from candles

Intervention Type OTHER

Generating fine and ultrafine particles from lit candles

Interventions

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Particles from candles

Generating fine and ultrafine particles from lit candles

Intervention Type OTHER

Particles from cooking

Generating fine and ultrafine particles from frying pork in an oven

Intervention Type OTHER

Clean Air

Nothing but clean air

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged 15-25
* Medically treated / physician diagnosed mild seasonal asthma
* Never smoker or ex-smoker ≥ 6 months
* Allergy \> 1 common allergy

Exclusion Criteria

* Any other disease that could influence the study parameters
* Conditions that prevent safe access to the climate chambers (such as claustrophobia)
* Perennial asthma
* Need for continuous medical treatment for asthma
* Pregnancy
Minimum Eligible Age

15 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Copenhagen

OTHER

Sponsor Role collaborator

Aarhus University Hospital

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Torben Sigsgaard

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Karin R Laursen, MSc

Role: PRINCIPAL_INVESTIGATOR

Department of Public Health, Aarhus Universitet

Locations

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Climate Chambers, Dept. Public Health, Aarhus University

Aarhus, Central Region Denmark, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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191100

Identifier Type: -

Identifier Source: org_study_id