Clinico-biological Collection of Subjects With Hyper Lipoprotein a in Reunion Island
NCT ID: NCT04310917
Last Updated: 2022-08-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2020-09-19
2023-06-30
Brief Summary
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High plasma levels of Lipoprotein (a) remain a major risk for the development of cardiovascular disease and its clinical complications, which no drug can currently reduce. Understanding the biological and genetic determinants modulating Lp (a) levels remains a major challenge for treating subjects with hyper Lp (a). Several individuals and possibly Reunion families have been detected as having abnormally high rates of apo (a)
Thanks to the link between cardiovascular clinical picture, Lp (a) concentration and other biological markers, the study should allow a better understanding of the mechanisms underlying the cardiovascular risk in order to offer advice. prevention and care of at-risk subjects screened; or even avenues for adapted genetic counseling (DNA sequencing).
At the genetic level, several hypotheses could be explored making it possible to link the expression of the apo (a) protein to the genotype, in particular the presence of mutations in the gene, in the promoter region, polymorphisms, or epistatic regulation.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Lipoprotein a level
blood lipoprotein (a) test
blood lipoprotein (a) test
research specific blood sample
Interventions
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blood lipoprotein (a) test
research specific blood sample
Eligibility Criteria
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Inclusion Criteria
* be affiliated or beneficiary of a social security scheme
* signed consent
Exclusion Criteria
ALL
Yes
Sponsors
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Centre Hospitalier Universitaire de la Réunion
OTHER
Responsible Party
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Principal Investigators
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Ilya KHANTALIN, PH
Role: PRINCIPAL_INVESTIGATOR
CHU de la Réunion
Locations
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Centre Hospitalier Universitaire de la Réunion
Saint-Denis, , France
Countries
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Central Contacts
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Facility Contacts
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Lucie AUZANNEAU
Role: primary
Other Identifiers
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2020/CHU/01
Identifier Type: -
Identifier Source: org_study_id
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