Cultivation of Hyalocytes From ILM and ERM Samples: a Pilot Study
NCT ID: NCT04306718
Last Updated: 2024-06-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
30 participants
INTERVENTIONAL
2019-10-01
2024-06-30
Brief Summary
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Detailed Description
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ILM is routinely excised during surgical repair of macular holes. During peeling of ERM it is excised in case of persisting wrinkling of the retinal surface or partial en bloc excision with the ERM. Furthermore, excision of ILM during ERM peeling is associated with significantly lower recurrence rates of ERM and better Long term visual acuity, according to the results reported by Chang et al. Removal of ERM and ILM is part of the surgical routine during surgical repair of macular holes and peeling of epiretinal membranes. Therefore, cultivation of excised ERM and ILM samples does not increase risks for patients in any way. During study it is planned to cultivate hyalocytes for investigation of their role in macular hole closure.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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studyarm
Hyalocytes from ERM and ILM are cultured in alphaMEM to examine their proliferation habits
membrane peeling
ERM and ILM are peeled routinely during surgery
Interventions
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membrane peeling
ERM and ILM are peeled routinely during surgery
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Vienna Institute for Research in Ocular Surgery
OTHER
Responsible Party
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Prim. Prof. Dr. Oliver Findl, MBA
Head of department, Professor
Principal Investigators
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Oliver Findl, Prof., Dr.
Role: PRINCIPAL_INVESTIGATOR
VIROS at Hanuschkrankenhaus
Locations
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VIROS at Hanuschkrankenhaus
Vienna, , Austria
Countries
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References
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Chang WC, Lin C, Lee CH, Sung TL, Tung TH, Liu JH. Vitrectomy with or without internal limiting membrane peeling for idiopathic epiretinal membrane: A meta-analysis. PLoS One. 2017 Jun 16;12(6):e0179105. doi: 10.1371/journal.pone.0179105. eCollection 2017.
Other Identifiers
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hya
Identifier Type: -
Identifier Source: org_study_id
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