The Feasibility of a Physical Activity Intervention for Advanced Multiple Myeloma Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-02

Study Completion Date

2018-12-20

Brief Summary

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Although physical activity (PA) is commonly used to manage symptoms and enhance quality of life (QOL) in cancer survivors, relatively little is known regarding the benefits in advanced multiple myeloma (MM). The primary aims of the Physical Activity in Advanced Cancer Treatment (PAACT) intervention were to examine (1) program feasibility and (2) potential impact on patient outcomes. It is hypothesized that an exercise intervention will be feasible and potentially impactful.

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Detailed Description

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While the introduction of novel and more effective treatments has seen improved survival in multiple myeloma (MM), the aggressive nature of the disease and these corresponding agents can have a debilitating impact on quality of life (QOL). Exercise can help manage symptoms and enhance QOL in cancer survivors, however relatively little is known regarding the feasibility or benefits of exercise in MM. The purpose of this study was to examine the feasibility of a group- and home-based exercise intervention for individuals with advanced MM. In this single arm study, advanced MM patients (DS stage II-III) participated in a 12-week aerobic and resistance training intervention, with the option of palliative care consultation. Participants attended once weekly supervised group exercise classes and received individually tailored home exercise booklets. Validated measures of physical functioning and patient-reported outcomes, including QOL, fatigue, anxiety, depression, and self-compassion were obtained at baseline and 12-weeks (post-intervention). Optional semi-structured interviews were conducted halfway (week 6) and at the end of the intervention (week 12)

Conditions

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Multiple Myeloma Hematologic Neoplasms Advanced Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Single group feasibility study

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Exercise group

Single-arm study. Participants enrolled engaged in a 12-week exercise program.

Group Type EXPERIMENTAL

Physical Activity for Advanced Cancer Treatment (PAACT)

Intervention Type BEHAVIORAL

12-week physical activity intervention. 60 minute group-based exercise classes held once per week. Home-based exercise recommendations provided weekly along with basic take-home exercise equipment. Optional palliative care consultations offered.

Interventions

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Physical Activity for Advanced Cancer Treatment (PAACT)

12-week physical activity intervention. 60 minute group-based exercise classes held once per week. Home-based exercise recommendations provided weekly along with basic take-home exercise equipment. Optional palliative care consultations offered.

Intervention Type BEHAVIORAL

Other Intervention Names

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PAACT

Eligibility Criteria

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Inclusion Criteria

* diagnosed with advanced (Durie-Salmon stage II-III) multiple myeloma
* 18 years of age or older and given a survival prognosis greater than 6 months
* stable hemoglobin level of ≥80g/L as measured within 2 weeks of enrollment
* no active infections at the time of enrollment.

Exclusion Criteria

* refusal of informed consent
* geographically inaccessible
* non-English speaking
* co-morbidities that interfere with participation (i.e., severe mobility issues or cognitive impairments)
* known or active history of substance abuse

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No