Trial Outcomes & Findings for Delicious Eating for Life in Southern Homes (NCT NCT04302727)

Last Updated: 2025-11-03

Results Overview

Weight will be collected by study staff who are masked to treatment using scales tested monthly for accuracy up to 350 pounds.

Recruitment status

COMPLETED

Study phase

Target enrollment

360 participants

Primary outcome timeframe

Baseline, Month 24

Results posted on

2025-11-03

Participant Flow

Participant milestones

Participant milestones
Measure	Med-South Weight Loss Intervention The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.	Augmented Usual Care (WW) The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.
Overall Study STARTED	182	178
Overall Study COMPLETED	118	129
Overall Study NOT COMPLETED	64	49

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Delicious Eating for Life in Southern Homes

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Total n=360 Participants Total of all reporting groups	Augmented Usual Care (WW) n=178 Participants The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.	Med-South Weight Loss Intervention n=182 Participants The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.
Age, Continuous	54.7 years STANDARD_DEVIATION 12.0 • n=18 Participants	55.0 years STANDARD_DEVIATION 11.6 • n=15 Participants	54.3 years STANDARD_DEVIATION 12.5 • n=3 Participants
Sex/Gender, Customized Male	158 Participants n=18 Participants	80 Participants n=15 Participants	78 Participants n=3 Participants
Sex/Gender, Customized Female	200 Participants n=18 Participants	96 Participants n=15 Participants	104 Participants n=3 Participants
Sex/Gender, Customized Non-Binary	2 Participants n=18 Participants	2 Participants n=15 Participants	0 Participants n=3 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	18 Participants n=18 Participants	12 Participants n=15 Participants	6 Participants n=3 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	342 Participants n=18 Participants	166 Participants n=15 Participants	176 Participants n=3 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=18 Participants	0 Participants n=15 Participants	0 Participants n=3 Participants
Race (NIH/OMB) American Indian or Alaska Native	2 Participants n=18 Participants	1 Participants n=15 Participants	1 Participants n=3 Participants
Race (NIH/OMB) Asian	5 Participants n=18 Participants	3 Participants n=15 Participants	2 Participants n=3 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=18 Participants	0 Participants n=15 Participants	0 Participants n=3 Participants
Race (NIH/OMB) Black or African American	119 Participants n=18 Participants	64 Participants n=15 Participants	55 Participants n=3 Participants
Race (NIH/OMB) White	215 Participants n=18 Participants	102 Participants n=15 Participants	113 Participants n=3 Participants
Race (NIH/OMB) More than one race	16 Participants n=18 Participants	7 Participants n=15 Participants	9 Participants n=3 Participants
Race (NIH/OMB) Unknown or Not Reported	3 Participants n=18 Participants	1 Participants n=15 Participants	2 Participants n=3 Participants
Region of Enrollment United States	360 Participants n=18 Participants	178 Participants n=15 Participants	182 Participants n=3 Participants

PRIMARY outcome

Timeframe: Baseline, Month 24

Weight will be collected by study staff who are masked to treatment using scales tested monthly for accuracy up to 350 pounds.

Outcome measures

Outcome measures
Measure	Med-South Weight Loss Intervention n=118 Participants The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.	Augmented Usual Care (WW) n=129 Participants The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.
Percent Weight Change From Baseline to Month 24	-4.4 percentage weight change Standard Deviation 7.45	-3.8 percentage weight change Standard Deviation 6.00

SECONDARY outcome

Timeframe: Baseline, Months 4 and 12

Population: Data reported for all participants who returned for follow-up measures.

Weight will be collected by study staff who are masked to treatment using scales tested monthly for accuracy up to 350 pounds.

Outcome measures

Outcome measures
Measure	Med-South Weight Loss Intervention n=146 Participants The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.	Augmented Usual Care (WW) n=152 Participants The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.
Percent Weight Change From Baseline to Months 4 and 12 Baseline, Month 4	-0.9 percentage weight change Standard Deviation 3.96	-4.4 percentage weight change Standard Deviation 5.01
Percent Weight Change From Baseline to Months 4 and 12 Baseline, Month 12	-4.6 percentage weight change Standard Deviation 6.20	-4.3 percentage weight change Standard Deviation 6.18

SECONDARY outcome

Timeframe: Baseline, Months 4, 12, and 24

Population: Data reported for all participants who returned for follow-up measures.

Weight will be collected by study staff who are masked to treatment using scales tested monthly for accuracy up to 350 pounds. Assess difference between study groups in percentage losing ≥ 5% body weight for all participants and across 3 pre-specified subgroups: 1) participants with vs. without diabetes; 2) females vs. males; and 3) Whites vs. African Americans.

Outcome measures
Measure	Med-South Weight Loss Intervention n=141 Participants The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.	Augmented Usual Care (WW) n=151 Participants The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.
Mean Change in Self-Weighing Behaviors From Baseline Through Follow-Up Baseline, Month 4	1.1 score on a scale Standard Deviation 1.60	0.6 score on a scale Standard Deviation 1.25
Mean Change in Self-Weighing Behaviors From Baseline Through Follow-Up Baseline, Month 12	1.7 score on a scale Standard Deviation 1.64	0.5 score on a scale Standard Deviation 1.24
Mean Change in Self-Weighing Behaviors From Baseline Through Follow-Up Baseline, Month 24	1.5 score on a scale Standard Deviation 1.57	0.3 score on a scale Standard Deviation 1.28

SECONDARY outcome

Timeframe: Month 24

Computed as the incremental cost per kilogram of weight loss relative to control. The budgetary assessment will quantify the total and per participant costs of intervention delivery from the health system perspective using an Activity Based Costing (ABC) approach and cost tracking forms that the health economist (Finkelstein) has developed and refined in past behavioral trials. Using this approach, all relevant labor, materials and supplies, contracted services, and other relevant costs required to deliver the interventions will be captured by key activities

Outcome measures

Outcome measures
Measure	Med-South Weight Loss Intervention n=118 Participants The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.	Augmented Usual Care (WW) n=129 Participants The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.
Economic Outcome--Incremental Cost-Effectiveness	NA U.S. dollars/Kg Below the level of detection since the adjusted difference in percent weight change between study arms was minimal. The effectiveness results were equivalent, resulting in a zero denominator in the Incremental Cost-Effectiveness Ratio (ICER) calculation. This made the ICER mathematically undefined, and no participants were analyzed for this outcome	NA U.S. dollars/Kg Below the level of detection since the adjusted difference in percent weight change between study arms was minimal. The effectiveness results were equivalent, resulting in a zero denominator in the Incremental Cost-Effectiveness Ratio (ICER) calculation. This made the ICER mathematically undefined, and no participants were analyzed for this outcome

SECONDARY outcome

Timeframe: Month 24

The numerator for this analysis will be the incremental program delivery costs of the intervention relative to control, minus any cost offsets based on differences in health services and medication use across arms. The denominator will be the incremental QALYs based on average differences in Euro Quality of Life five Dimensions Questionnaire (EQ-5D-5L) scores across arms collected at each assessment point. These scores can be used to quantify net QALY differences during the intervention period. EQ-5D-5L scale measures patients' quality of healthy living. It has 5 items (Mobility, Self-care, Usual activities, Pain/discomfort, Depression/anxiety). The score calculation of the European Five-Dimensional Health Scale is based on the calculation formula published by the EuroQol Group. Based on 5 combinations of different severity levels, a score of 0 to 1 is obtained. 0 is the least healthy and 1 is the most healthy.

Outcome measures

Outcome measures
Measure	Med-South Weight Loss Intervention n=118 Participants The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.	Augmented Usual Care (WW) n=129 Participants The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.
Economic Outcome--Incremental Cost Per Quality Adjusted Life Year (QALY) Gained	NA U.S. dollars per QALY Below the level of detection since the adjusted difference in percent weight change between study arms was minimal. The effectiveness results were equivalent, resulting in a zero denominator in the Incremental Cost-Effectiveness Ratio (ICER) calculation. This made the ICER mathematically undefined, and no participants were analyzed for this outcome.	NA U.S. dollars per QALY Below the level of detection since the adjusted difference in percent weight change between study arms was minimal. The effectiveness results were equivalent, resulting in a zero denominator in the Incremental Cost-Effectiveness Ratio (ICER) calculation. This made the ICER mathematically undefined, and no participants were analyzed for this outcome.

Adverse Events

Augmented Usual Care (WW)

Serious events: 10 serious events

Other events: 31 other events

Deaths: 0 deaths

Med-South Weight Loss Intervention

Serious events: 24 serious events

Other events: 27 other events

Deaths: 0 deaths

Serious adverse events

Other adverse events

Other adverse events
Measure	Augmented Usual Care (WW) n=178 participants at risk The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.	Med-South Weight Loss Intervention n=182 participants at risk The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.
Metabolism and nutrition disorders Hypoglycemia	7.3% 13/178 • Number of events 21 • From the time of randomization to the final follow-up visit, a total of approximately 24 months (the defined window for the final follow-up was 23-30 months). For those who did not attend the final follow-up visit, reports for hospitalization were reviewed from the electronic health record for 2 years post randomization. Adverse events were captured using the electronic health record report for hospitalizations and by participant-completed surveys at follow-up visits.	7.7% 14/182 • Number of events 19 • From the time of randomization to the final follow-up visit, a total of approximately 24 months (the defined window for the final follow-up was 23-30 months). For those who did not attend the final follow-up visit, reports for hospitalization were reviewed from the electronic health record for 2 years post randomization. Adverse events were captured using the electronic health record report for hospitalizations and by participant-completed surveys at follow-up visits.
Cardiac disorders Dizziness	13.5% 24/178 • Number of events 33 • From the time of randomization to the final follow-up visit, a total of approximately 24 months (the defined window for the final follow-up was 23-30 months). For those who did not attend the final follow-up visit, reports for hospitalization were reviewed from the electronic health record for 2 years post randomization. Adverse events were captured using the electronic health record report for hospitalizations and by participant-completed surveys at follow-up visits.	12.1% 22/182 • Number of events 30 • From the time of randomization to the final follow-up visit, a total of approximately 24 months (the defined window for the final follow-up was 23-30 months). For those who did not attend the final follow-up visit, reports for hospitalization were reviewed from the electronic health record for 2 years post randomization. Adverse events were captured using the electronic health record report for hospitalizations and by participant-completed surveys at follow-up visits.

Additional Information

Thomas Keyserling, MD

University of North Carolina at Chapel Hill

Phone: 984-974-4462

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place

Measure	Med-South Weight Loss Intervention n=146 Participants The intervention will be delivered in 3 phases over 24 months: Phase I (4 months) provides a foundation for adopting and maintaining a healthful dietary pattern (Med-style, tailored for the southeastern United States); Phase II (8 months) focuses on weight loss; and Phase III (12 months) on maintenance of or continued weight loss, as appropriate. Med-South Weight Loss Intervention: Phase I is a 4-month lifestyle program focused on the basics of healthy eating. Phase II (8 months) focuses on weight loss, followed by a year-long (Phase III) focused on weight loss maintenance. In Phase I, the main counseling sessions happen at monthly visits, with added check-in phone calls. In Phase II, the main counseling sessions will occur weekly for 6-8 weeks. There are also check-in phone calls - number based on weight loss progress. During Phase III, there are 2 main visits and follow-up phone calls. Counseling visits will be in-person with a health counselor and by phone. Of the 14 core counseling sessions, the in-person format will be required for only 4 (the 1st session of each Phase and after 2 months of the weight loss program). The program also includes brief phone calls to check on progress towards goals for lifestyle change. The number of phone calls will depend on success in meeting personal weight loss goals in Phase II or keeping the weight off in Phase III.	Augmented Usual Care (WW) n=152 Participants The intervention that will be offered to control group participants is WW™ (also known as Weight Watchers). The study will provide access to the 'Workshop + Digital' option of WW™ during the 2 year intervention. WW: If participants are randomized to WW™, they will have access to both the workshop and digital components of the WW™ program for 2 years. The workshop component includes the option of attending weekly group meeting at a WW™ studio (local WW™ office). The digital component can be accessed using the WW™ website or the smart phone App. The study research staff will provide basic instructions on how to use the WW™ digital resources.
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Males-Baseline, Month 4	-1.7 percentage weight change Standard Deviation 4.08	-4.8 percentage weight change Standard Deviation 5.29
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Whites-Baseline, Month 4	-1.2 percentage weight change Standard Deviation 3.96	-5.6 percentage weight change Standard Deviation 5.38
Percentage Weight From Baseline Through Follow-Up by Sub-Groups African Americans-Baseline, Month 4	-0.5 percentage weight change Standard Deviation 3.95	-2.5 percentage weight change Standard Deviation 3.68
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Participants with diabetes-Baseline, Month 12	-4.2 percentage weight change Standard Deviation 5.97	-3.9 percentage weight change Standard Deviation 6.78
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Participants without diabetes-Baseline, Month 12	-4.8 percentage weight change Standard Deviation 6.32	-4.5 percentage weight change Standard Deviation 5.87
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Males-Baseline, Month 12	-6.2 percentage weight change Standard Deviation 6.06	-5.0 percentage weight change Standard Deviation 6.44
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Whites-Baseline, Month 12	-5.4 percentage weight change Standard Deviation 6.85	-5.6 percentage weight change Standard Deviation 6.53
Percentage Weight From Baseline Through Follow-Up by Sub-Groups African Americans-Baseline, Month 12	-3.0 percentage weight change Standard Deviation 4.09	-2.5 percentage weight change Standard Deviation 5.19
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Participants with diabetes-Baseline, Month 24	-4.7 percentage weight change Standard Deviation 6.57	-5.0 percentage weight change Standard Deviation 6.30
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Participants without diabetes-Baseline, Month 24	-4.3 percentage weight change Standard Deviation 7.87	-3.1 percentage weight change Standard Deviation 5.78
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Females-Baseline, Month 24	-3.6 percentage weight change Standard Deviation 7.69	-3.6 percentage weight change Standard Deviation 6.40
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Males-Baseline, Month 24	-5.5 percentage weight change Standard Deviation 7.08	-3.9 percentage weight change Standard Deviation 5.54
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Whites-Baseline, Month 24	-4.9 percentage weight change Standard Deviation 7.73	-4.2 percentage weight change Standard Deviation 5.99
Percentage Weight From Baseline Through Follow-Up by Sub-Groups African Americans-Baseline, Month 24	-3.5 percentage weight change Standard Deviation 6.81	-3.1 percentage weight change Standard Deviation 6.02
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Participants without diabetes-Baseline, Month 4	-0.6 percentage weight change Standard Deviation 4.06	-4.7 percentage weight change Standard Deviation 5.19
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Females-Baseline, Month 4	-0.3 percentage weight change Standard Deviation 3.77	-4.0 percentage weight change Standard Deviation 4.77
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Females-Baseline, Month 12	-3.3 percentage weight change Standard Deviation 6.04	-3.7 percentage weight change Standard Deviation 5.98
Percentage Weight From Baseline Through Follow-Up by Sub-Groups Participants with diabetes-Baseline, Month 4	-1.7 percentage weight change Standard Deviation 3.63	-3.7 percentage weight change Standard Deviation 4.56