Trial Outcomes & Findings for MRI Assessing Clinical Usability of STrategically Acquired Gradient Echo on Human Participants (NCT NCT04292301)
NCT ID: NCT04292301
Last Updated: 2022-06-28
Results Overview
Reading radiologists responses on the clinical usability of STAGE Outputs based on image quality using a numeric rating scale of 1 to 5 with: 1=unacceptable, 2=poor, 3=acceptable, 4=good, 5=excellent. Scores of 3 or greater are considered clinically usable.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
92 participants
Primary outcome timeframe
Baseline Only
Results posted on
2022-06-28
Participant Flow
Subject recruitment took place across three sites and resulted in a total of 92 participant enrollment with 89 participants remaining after attrition. Recruitment took place between July 2020 and December 2020.
Participant milestones
| Measure |
STrategically Acquired Gradient Echo (STAGE)
STAGE Inputs are flow compensated 3D gradient echo MR images acquired at optimal parameters which are used to calculate multiple contrasts for brain imaging. All subjects within the study are imaged using both a conventional MR protocol and STAGE protocol.
STrategically Acquired Gradient Echo (STAGE): The STAGE package uses conventional 3D gradient echo MR, its magnitude and phase, collected at set parameters which allow for the reconstruction of multiple MR datasets which results in decreased acquisition time, equivalency to conventional MR, and the decrease in scan time allows for a higher standard of wealth within the data acquired.
|
|---|---|
|
Overall Study
STARTED
|
92
|
|
Overall Study
COMPLETED
|
89
|
|
Overall Study
NOT COMPLETED
|
3
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
STrategically Acquired Gradient Echo (STAGE)
n=92 Participants
STAGE Inputs are flow compensated 3D gradient echo MR images acquired at optimal parameters which are used to calculate multiple contrasts for brain imaging. All subjects within the study are imaged using both a conventional MR protocol and STAGE protocol.
STrategically Acquired Gradient Echo (STAGE): The STAGE package uses conventional 3D gradient echo MR, its magnitude and phase, collected at set parameters which allow for the reconstruction of multiple MR datasets which results in decreased acquisition time, equivalency to conventional MR, and the decrease in scan time allows for a higher standard of wealth within the data acquired.
|
|---|---|
|
Age, Categorical
<=18 years
|
1 Participants
n=92 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
89 Participants
n=92 Participants
|
|
Age, Categorical
>=65 years
|
2 Participants
n=92 Participants
|
|
Age, Continuous
|
33.4 years
STANDARD_DEVIATION 12.2 • n=92 Participants
|
|
Sex: Female, Male
Female
|
53 Participants
n=92 Participants
|
|
Sex: Female, Male
Male
|
39 Participants
n=92 Participants
|
|
Region of Enrollment
United States
|
92 participants
n=92 Participants
|
PRIMARY outcome
Timeframe: Baseline OnlyPopulation: Scores of 3 or greater are considered clinically acceptable. The count of participants is presented for each score and for each STAGE output series.
Reading radiologists responses on the clinical usability of STAGE Outputs based on image quality using a numeric rating scale of 1 to 5 with: 1=unacceptable, 2=poor, 3=acceptable, 4=good, 5=excellent. Scores of 3 or greater are considered clinically usable.
Outcome measures
| Measure |
STrategically Acquired Gradient Echo (STAGE)
n=89 Participants
STAGE Inputs are flow compensated 3D gradient echo MR images acquired at optimal parameters which are used to calculate multiple contrasts for brain imaging. All subjects within the study are imaged using both a conventional MR protocol and STAGE protocol.
STrategically Acquired Gradient Echo (STAGE): The STAGE package uses conventional 3D gradient echo MR, its magnitude and phase, collected at set parameters which allow for the reconstruction of multiple MR datasets which results in decreased acquisition time, equivalency to conventional MR, and the decrease in scan time allows for a higher standard of wealth within the data acquired.
|
|---|---|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE DIR Score<=2
|
1 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Score=4
|
37 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Score=3
|
3 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Coronal Score=5
|
38 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Coronal Score=4
|
28 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Coronal Score=3
|
23 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Coronal Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Sagittal Score=5
|
44 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Sagittal Score=4
|
24 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Sagittal Score=3
|
21 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Sagittal Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1 MAP Score=5
|
48 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1 MAP Score=4
|
40 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1 MAP Score=3
|
1 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1 MAP Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE PD MAP Score=5
|
48 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE PD MAP Score=4
|
39 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE PD MAP Score=3
|
2 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE PD MAP Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE SWI Score=5
|
1 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE SWI Score=4
|
54 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE SWI Score=3
|
34 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE SWI Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE tSWI Score=5
|
3 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE tSWI Score=4
|
55 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE tSWI Score=3
|
31 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE tSWI Score=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE iSWIM Score=5
|
9 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE iSWIM Score=4
|
58 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE iSWIM Score=3
|
21 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE iSWIM Score<=2
|
1 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE R2* MAP Score=5
|
26 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE R2* MAP Score=4
|
35 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE R2* MAP Score=3
|
27 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE R2* MAP Score<=2
|
1 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T2* MAP Score=5
|
2 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T2* MAP Score=4
|
35 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T2* MAP Score=3
|
51 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T2* MAP Score<=2
|
1 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE MRA Score=5
|
35 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE MRA Score=4
|
27 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE MRA Score=3
|
27 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE MRA Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE pSWIM Score=5
|
34 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE pSWIM Score=4
|
33 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE pSWIM Score=3
|
22 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE pSWIM Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE mpSWIM Score=5
|
36 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE mpSWIM Score=4
|
31 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE mpSWIM Score=3
|
22 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE mpSWIM Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE DIR Score=5
|
45 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE DIR Score=4
|
21 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE DIR Score=3
|
22 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional T1W Input Score=5
|
49 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional T1W Input Score=4
|
40 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional T1W Input Score=3
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional T1W Input Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional PDW Input Score=5
|
44 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional PDW Input Score=4
|
45 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional PDW Input Score=3
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional PDW Input Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional MPRAGE Score=5
|
49 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional MPRAGE Score=4
|
40 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional MPRAGE Score=3
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Conventional MPRAGE Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1W Score=5
|
49 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1W Score=4
|
39 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1W Score=3
|
1 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1W Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE PDW Score=5
|
36 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE PDW Score=4
|
50 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE PDW Score=3
|
3 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE PDW Score<=2
|
0 Participants
|
|
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
STAGE T1We Score=5
|
49 Participants
|
PRIMARY outcome
Timeframe: Baseline OnlyPopulation: Reported number of observed artifacts within image series are shown as a count.
Reading radiologist and image analyst responses on the clinical usability of STAGE Outputs based on image quality using a yes/no criteria for presence of novel or accentuated imaging artifact. Hardware or participant artifact contributions (i.e. coil sensitivity and motion) were not considered unless noted as increased due to the STAGE method. Each image series was evaluated for the presence of artifact. The total count of the artifacts reported across series evaluated in the study is reported.
Outcome measures
| Measure |
STrategically Acquired Gradient Echo (STAGE)
n=89 Image Series
STAGE Inputs are flow compensated 3D gradient echo MR images acquired at optimal parameters which are used to calculate multiple contrasts for brain imaging. All subjects within the study are imaged using both a conventional MR protocol and STAGE protocol.
STrategically Acquired Gradient Echo (STAGE): The STAGE package uses conventional 3D gradient echo MR, its magnitude and phase, collected at set parameters which allow for the reconstruction of multiple MR datasets which results in decreased acquisition time, equivalency to conventional MR, and the decrease in scan time allows for a higher standard of wealth within the data acquired.
|
|---|---|
|
Review of STAGE Outputs for Artifact and Image Contrast
Conventional T1MPRAGE
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
Conventional T1W
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
Conventional PDW
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE T1W
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE PDW
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE T1WE
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE T1MAP
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE PDMAP
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE SWI
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE tSWI
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE iSWIM
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE R2*MAP
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE T2*MAP
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE MRA
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE pSWIM
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE mpSWIM
|
0 Artifact Count
|
|
Review of STAGE Outputs for Artifact and Image Contrast
STAGE DIR
|
0 Artifact Count
|
PRIMARY outcome
Timeframe: Baseline OnlyPopulation: Image series were evaluated for 1) correct artery/vein appearance, 2) calcium/iron appearance, and 3) contrast between gray matter, white matter, and cerebrospinal fluid. Data were evaluated across all STAGE output images based on these structures appearance. The count of image series units is shown as either meeting criteria or not.
Reading radiologists responses on the clinical usability of STAGE Outputs based on image appearance of specified brain structures using pass/fail criteria. Expected brain contrast between tissue types will vary depending on the output reviewed (i.e. T1W, PDW, SWI). The behavior of tissue contrasts (i.e. white matter vs gray matter) should also demonstrate standard anatomic contrast (T1W, PDW, SWI) as well quantitative ratio for maps (T2\*MAP, R2\*MAP, SWIM, T1MAP, PDMAP). For artery/vein appearance, STAGE T1W, T1MAP and PD MAP were not evaluated due to artery/vein not appearing in the image contrasts. For GM/WM/CSF, the MRA, pSWIM and mpSWIM were not evaluated due to the anatomic contrast not appearing in the image contrasts. For calcium/iron appearance, T1WE, T1MAP, PDMAP, MRA, and DIR were not evaluated due to the calcium/iron not appearing in the image contrasts.
Outcome measures
| Measure |
STrategically Acquired Gradient Echo (STAGE)
n=89 Image Series
STAGE Inputs are flow compensated 3D gradient echo MR images acquired at optimal parameters which are used to calculate multiple contrasts for brain imaging. All subjects within the study are imaged using both a conventional MR protocol and STAGE protocol.
STrategically Acquired Gradient Echo (STAGE): The STAGE package uses conventional 3D gradient echo MR, its magnitude and phase, collected at set parameters which allow for the reconstruction of multiple MR datasets which results in decreased acquisition time, equivalency to conventional MR, and the decrease in scan time allows for a higher standard of wealth within the data acquired.
|
|---|---|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE T2*MAP Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · Conventional PDW Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · Conventional PDW Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE T1W Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE T1W Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE PDW Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE PDW Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE SWI Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE SWI Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE tSWI Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE tSWI Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE iSWIM Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE iSWIM Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE R2*MAP Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE R2*MAP Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE T2*MAP Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE T2*MAP Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE MRA Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE MRA Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE pSWIM Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE pSWIM Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE mpSWIM Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE mpSWIM Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · Conventional T1MPRAGE Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · Conventional T1MPRAGE Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · Conventional T1W Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · Conventional T1W Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE T1WE Criteria Met
|
NA Image Series
T1WE can not be properly assessed for Artery/Vein appearance due to the lack of signal in Artery/Vein in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE T1WE Criteria Not Met
|
NA Image Series
T1WE can not be properly assessed for Artery/Vein appearance due to the lack of signal in Artery/Vein in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE T1MAP Criteria Met
|
NA Image Series
T1MAP can not be properly assessed for Artery/Vein appearance due to the lack of signal in Artery/Vein in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE T1MAP Criteria Not Met
|
NA Image Series
T1MAP can not be properly assessed for Artery/Vein appearance due to the lack of signal in Artery/Vein in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE PDMAP Criteria Met
|
NA Image Series
PDMAP can not be properly assessed for Artery/Vein appearance due to the lack of signal in Artery/Vein in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE PDMAP Criteria Not Met
|
NA Image Series
PDMAP can not be properly assessed for Artery/Vein appearance due to the lack of signal in Artery/Vein in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE DIR Criteria Met
|
NA Image Series
DIR can not be properly assessed for Artery/Vein appearance due to the lack of signal in Artery/Vein in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Artery and Vein · STAGE DIR Criteria Not Met
|
NA Image Series
DIR can not be properly assessed for Artery/Vein appearance due to the lack of signal in Artery/Vein in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · Conventional T1MPRAGE Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · Conventional T1MPRAGE Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · Conventional T1W Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · Conventional T1W Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · Conventional PDW Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · Conventional PDW Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE T1W Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE T1W Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE PDW Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE PDW Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE SWI Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE SWI Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE tSWI Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE tSWI Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE iSWIM Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE iSWIM Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE R2*MAP Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE R2*MAP Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE T2*MAP Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE T2*MAP Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE MRA Criteria Met
|
NA Image Series
MRA can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE MRA Criteria Not Met
|
NA Image Series
MRA can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE pSWIM Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE pSWIM Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE mpSWIM Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE mpSWIM Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE T1WE Criteria Met
|
NA Image Series
T1WE can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE T1WE Criteria Not Met
|
NA Image Series
T1WE can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE T1MAP Criteria Met
|
NA Image Series
T1MAP can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE T1MAP Criteria Not Met
|
NA Image Series
T1MAP can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE PDMAP Criteria Met
|
NA Image Series
PDMAP can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE PDMAP Criteria Not Met
|
NA Image Series
PDMAP can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE DIR Criteria Met
|
NA Image Series
DIR can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Calcium and Iron · STAGE DIR Criteria Not Met
|
NA Image Series
DIR can not be properly assessed for Calcium/Iron appearance due to the lack of signal from Calcium/Iron in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · Conventional T1MPRAGE Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · Conventional T1MPRAGE Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · Conventional T1W Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · Conventional T1W Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · Conventional PDW Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · Conventional PDW Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE T1W Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE T1W Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE PDW Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE PDW Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE SWI Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE SWI Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE tSWI Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE tSWI Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE iSWIM Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE iSWIM Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE R2*MAP Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE R2*MAP Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE T2*MAP Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE MRA Criteria Met
|
NA Image Series
MRA can not be properly assessed for GM/WM/CSF appearance due to the lack of signal from GM/WM/CSF contrast in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE MRA Criteria Not Met
|
NA Image Series
MRA can not be properly assessed for GM/WM/CSF appearance due to the lack of signal from GM/WM/CSF contrast in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE pSWIM Criteria Met
|
NA Image Series
pSWIM can not be properly assessed for GM/WM/CSF appearance due to the lack of signal from GM/WM/CSF contrast in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE pSWIM Criteria Not Met
|
NA Image Series
pSWIM can not be properly assessed for GM/WM/CSF appearance due to the lack of signal from GM/WM/CSF contrast in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE mpSWIM Criteria Met
|
NA Image Series
mpSWIM can not be properly assessed for GM/WM/CSF appearance due to the lack of signal from GM/WM/CSF contrast in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE mpSWIM Criteria Not Met
|
NA Image Series
mpSWIM can not be properly assessed for GM/WM/CSF appearance due to the lack of signal from GM/WM/CSF contrast in the image series.
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE T1WE Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE T1WE Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE T1MAP Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE T1MAP Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE PDMAP Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE PDMAP Criteria Not Met
|
0 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE DIR Criteria Met
|
89 Image Series
|
|
Review of STAGE Outputs for Expected Brain Structural Appearance
Gray Matter / White Matter / Cerebrospinal Fluid · STAGE DIR Criteria Not Met
|
0 Image Series
|
PRIMARY outcome
Timeframe: Baseline OnlyPopulation: The average and minimum/maximum processing times for STAGE were evaluated across scanners, resolutions, and field strengths.
Review of the recorded processing times for the STAGE module to accept and process STAGE inputs and to export them back to the PACS as STAGE outputs.
Outcome measures
| Measure |
STrategically Acquired Gradient Echo (STAGE)
n=89 Participants
STAGE Inputs are flow compensated 3D gradient echo MR images acquired at optimal parameters which are used to calculate multiple contrasts for brain imaging. All subjects within the study are imaged using both a conventional MR protocol and STAGE protocol.
STrategically Acquired Gradient Echo (STAGE): The STAGE package uses conventional 3D gradient echo MR, its magnitude and phase, collected at set parameters which allow for the reconstruction of multiple MR datasets which results in decreased acquisition time, equivalency to conventional MR, and the decrease in scan time allows for a higher standard of wealth within the data acquired.
|
|---|---|
|
Evaluation of STAGE Image Processing Times
3T GE Signa Premier
|
17.4 Time (minutes)
Standard Deviation 3.2
|
|
Evaluation of STAGE Image Processing Times
1.5T Siemens Aera
|
7.6 Time (minutes)
Standard Deviation 0.8
|
|
Evaluation of STAGE Image Processing Times
3T Siemens Skyra
|
10.1 Time (minutes)
Standard Deviation 1.7
|
|
Evaluation of STAGE Image Processing Times
3T Siemens Prisma
|
11.3 Time (minutes)
Standard Deviation 2.0
|
Adverse Events
STrategically Acquired Gradient Echo (STAGE)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place