Prospective, Assessment of Vitamin D and Calcium Supplementation, Improvement of Nutritional Status and Preoperative Rehabilitation in Patients Before Knee Arthroplasty.

NCT ID: NCT04291833

Last Updated: 2020-03-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-01

Study Completion Date

2017-12-31

Brief Summary

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Prospective randomized study of 150 patients qualified for knee arthroplasty between 2015 and 2017. Patients were randomized into 3 groups receiving vitamin D and calcium supplementation, increased protein supply and preoperative rehabilitation, respectively.

Following factors were analyzed: changes in vitamin D3, calcium, total protein, albumin and CRP levels during preparation for surgery, nutritional status on the Subjective Global Assessment (SGA) scale, osteoporosis risk assessment according to the Osteoporosis Risk SCORE, level of pain felt on the scale VAS and the number of analgesics used, the result of the Duke Activity Status Index, the result of the following scales: Cardiac Risk Index for Orthopedic Surgery (Lee), Knee injury and Osteoarthritis Outcome Score (KOOS), Fear Avoidance Beliefs Questionnaire (FABQ) about Physical Activity, The Quality of Life Scale (QOLS). Additionally, the occurrence of perioperative complications was analyzed (e.g. venous thrombosis and pulmonary embolism, wound or joint infection, excessive bleeding, loosening of the implant, bone fracture or fracture, pain).

Detailed Description

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Conditions

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Knee Osteoarthritis Vitamin D Deficiency Pain, Postoperative Arthropathy of Knee

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Intervention group 1

Protein supplementation BID, Vitamin D and calcium supplementation Vitamin D 2000 IU / d, calcium 1000mg/d, exercise 6 months

Group Type ACTIVE_COMPARATOR

Intervention group 1

Intervention Type BEHAVIORAL

Protein supplementation BID, Vitamin D and calcium supplementation Vitamin D 2000 IU / d, calcium 1000mg/d, exercise 6 months

Intervention group 2

Protein supplementation QD, Vitamin D and calcium supplementation Vitamin D 1000 IU / d, calcium 500mg/d, exercise 3 months

Group Type ACTIVE_COMPARATOR

Intervention group 2

Intervention Type BEHAVIORAL

Protein supplementation QD, Vitamin D and calcium supplementation Vitamin D 1000 IU / d, calcium 500mg/d, exercise 3 months

Control group 0

no protein supplementation , no Vitamin D and calcium supplementation , no exercise

Group Type PLACEBO_COMPARATOR

Control group 0

Intervention Type BEHAVIORAL

no protein supplementation , no Vitamin D and calcium supplementation , no exercise

Interventions

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Intervention group 1

Protein supplementation BID, Vitamin D and calcium supplementation Vitamin D 2000 IU / d, calcium 1000mg/d, exercise 6 months

Intervention Type BEHAVIORAL

Intervention group 2

Protein supplementation QD, Vitamin D and calcium supplementation Vitamin D 1000 IU / d, calcium 500mg/d, exercise 3 months

Intervention Type BEHAVIORAL

Control group 0

no protein supplementation , no Vitamin D and calcium supplementation , no exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* with a disease lasting more than 5 years and without total limitation of physical fitness,
* reporting pain\> 5 on the VAS scale (Visual Analogue Scale)
* general fitness according to the ASA (Amercican Society of Anestesiology) scale up to 3

Exclusion Criteria

* patients with metabolic and systemic disorders with contraindications for calcium substitution, vitamin D3 and protein supply,
* intolerance of physical effort\> 2, 5 MET (Metabolic Equivalent of Task)
* limitation of the degree overall efficiency\> 3 in the ASA classification
Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jagiellonian University

OTHER

Sponsor Role lead

Responsible Party

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Bartlomiej Szpyra

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Bartlomiej Szpyra

Krakow, Malopolska, Poland

Site Status

Countries

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Poland

Other Identifiers

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KBET/271/B/2014

Identifier Type: -

Identifier Source: org_study_id

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