Placebo Development and Validation for Healing Water

NCT ID: NCT04290143

Last Updated: 2020-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

174 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-02-07

Brief Summary

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The study aimed to develop and validate an easy-to use cheap method capable of producing placebo from tap water.

Detailed Description

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Introduction: The beneficial health effects of healing waters have been reported by numerous studies. However, the lack of proper placebo substance makes the "medication-like" investigation of healing waters difficult. The investigators aimed to develop and validate an easy-to use cheap method capable of producing placebo from tap water.

Methods: Both medical water and tap water will be colored. The temperature and the pH of the tap water will be adjusted to the temperature pH of the healing water. The patients will be divided into two groups, colored healing water and placebo group. A single 20 minutes-long treatment will be performed in bath tubs. Considering the healing waters odor, the treatment will be given in the same room. Patients will be asked to tell whether they are treated with colored healing water or placebo or could not tell. Questions will be asked before the treatment, 10 minutes after the beginning of the treatment, immediately after the end of the treatment and after shower. The study will be performed in a double blind setup. Patients will be scored, one point for each correct answer.

Target patient number:174

Conditions

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Balneology

Keywords

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medical water healing water placebo

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

double blind study for testing a placebo development method
Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors
Both medical water and tap water will be colored. The temperature and the pH of the tap water will be adjusted to the temperature pH of the healing water.

Study Groups

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Colored healing water

Colored medical water in a bath tub. A single 20 minutes-long treatment will be performed.

Group Type ACTIVE_COMPARATOR

Colored healing water

Intervention Type OTHER

Patients will be treated with colored healing water for 20 minutes.

Placebo treatment (colored tap water)

Intervention Type OTHER

Patients will be treated with colored tap water for 20 minutes.

Placebo - Colored tap water

Colored tap water. The temperature and the pH of the tap water will be adjusted to the temperature pH of the healing water. A single 20 minutes-long treatment will be performed.

Group Type PLACEBO_COMPARATOR

Colored healing water

Intervention Type OTHER

Patients will be treated with colored healing water for 20 minutes.

Placebo treatment (colored tap water)

Intervention Type OTHER

Patients will be treated with colored tap water for 20 minutes.

Interventions

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Colored healing water

Patients will be treated with colored healing water for 20 minutes.

Intervention Type OTHER

Placebo treatment (colored tap water)

Patients will be treated with colored tap water for 20 minutes.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* willingness to participate in the study
* age between 18-80 years

Exclusion Criteria

* patients physically unable to enter or exit the bath tub
* autoimmune diseases
* any kind of malignity
* acute inflammation
* infection
* acute coronary syndrome or recent surgical interventions (6 month before enrollment)
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Harkány Spa Hospital, Harkány, Hungary

UNKNOWN

Sponsor Role collaborator

National Research, Development and Innovation Office, Budapest, Hungary

UNKNOWN

Sponsor Role collaborator

University of Pecs

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Katalin Dr Szendi, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Pecs

Locations

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Harkány Thermal Rehabilitation Centre

Harkány, Baranya, Hungary

Site Status

Katalin Dr Szendi

Pécs, Baranya, Hungary

Site Status

Countries

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Hungary

References

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Bender T, Balint G, Prohaszka Z, Geher P, Tefner IK. Evidence-based hydro- and balneotherapy in Hungary--a systematic review and meta-analysis. Int J Biometeorol. 2014 Apr;58(3):311-23. doi: 10.1007/s00484-013-0667-6. Epub 2013 May 16.

Reference Type BACKGROUND
PMID: 23677421 (View on PubMed)

Szucs L, Ratko I, Lesko T, Szoor I, Genti G, Balint G. Double-blind trial on the effectiveness of the Puspokladany thermal water on arthrosis of the knee-joints. J R Soc Health. 1989 Feb;109(1):7-9. doi: 10.1177/146642408910900104. No abstract available.

Reference Type BACKGROUND
PMID: 2494341 (View on PubMed)

Matsumoto S. Evaluation of the Role of Balneotherapy in Rehabilitation Medicine. J Nippon Med Sch. 2018;85(4):196-203. doi: 10.1272/jnms.JNMS.2018_85-30.

Reference Type BACKGROUND
PMID: 30259887 (View on PubMed)

Morer C, Roques CF, Francon A, Forestier R, Maraver F. The role of mineral elements and other chemical compounds used in balneology: data from double-blind randomized clinical trials. Int J Biometeorol. 2017 Dec;61(12):2159-2173. doi: 10.1007/s00484-017-1421-2. Epub 2017 Aug 28.

Reference Type BACKGROUND
PMID: 28849535 (View on PubMed)

Hanzel A, Horvat K, Molics B, Berenyi K, Nemeth B, Szendi K, Varga C. Clinical improvement of patients with osteoarthritis using thermal mineral water at Szigetvar Spa-results of a randomised double-blind controlled study. Int J Biometeorol. 2018 Feb;62(2):253-259. doi: 10.1007/s00484-017-1446-6. Epub 2017 Sep 27.

Reference Type BACKGROUND
PMID: 28956169 (View on PubMed)

Hanzel A, Berenyi K, Horvath K, Szendi K, Nemeth B, Varga C. Evidence for the therapeutic effect of the organic content in Szigetvar thermal water on osteoarthritis: a double-blind, randomized, controlled clinical trial. Int J Biometeorol. 2019 Apr;63(4):449-458. doi: 10.1007/s00484-019-01676-3. Epub 2019 Feb 7.

Reference Type BACKGROUND
PMID: 30734126 (View on PubMed)

Other Identifiers

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OTKA_131531_PLACEBO

Identifier Type: -

Identifier Source: org_study_id