Endoscopic Findings of Gastritis in Children

NCT ID: NCT04289519

Last Updated: 2020-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-30

Study Completion Date

2021-04-30

Brief Summary

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Gastritis defines any (histologically confirmed) inflammation of the gastric mucosa

Detailed Description

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Gastritis is a very common disease in children. The main presentation of children with gastritis is recurrent abdominal pain and dyspepsia or vomiting. Young children may have hematemesis or melena as presentation. Drug induced or food related gastritis presents usually with acute symptoms but Helicobacter pylori gastritis have mainly recurrent abdominal pain and dyspeptic symptoms. Other presentations include diarrhea, constipation, flatulence, bloating, fatigue, low energy level, weight loss, muscle loss, bad breath etc.

The main causes of gastritis are infections, inflammation and other disorders affect the gastric mucosa in pediatric patients. Helicobacter pylori infection is the most common cause of gastritis in children which is also responsible for the majority of duodenal ulcers.

Acute erosive gastritis is most commonly the result of metabolic stress or drug or corrosive injury.

Other major causes of gastritis include celiac disease, allergic disorders, and Crohn's disease .Medication as NSAIDs, uremia, ischemia, shock, radiation, sepsis, trauma, severe burns and surgery.

Endoscopic pictures in acute gastritis may be in the form of:

* Multiple round-shaped severe erosions with a diameter of several millimeters.
* Mucosal edema, hyperemia.
* Peptic ulcer While in chronic gastritis is variable. Affects the antrum in the beginning and advances to the proximal in time .

Conditions

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Gastritis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* All children diagnosed as gastritis by upper endoscopy and bio gastric biopsy

Exclusion Criteria

* • All children underwent upper endoscopy during the study period not diagnosed as gastritis
Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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HM Reyad

principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Naglaa Hassan, Professor

Role: CONTACT

Phone: 01111872237

Email: [email protected]

Amira Mohamed, Lecturer

Role: CONTACT

Phone: 01223958949

Email: [email protected]

References

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Pasechnikov VD, Chukov SZ, Kotelevets SM, Mostovov AN, Mernova VP, Polyakova MB. Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study. Scand J Gastroenterol. 2005 Mar;40(3):297-301. doi: 10.1080/00365520410010607.

Reference Type BACKGROUND
PMID: 15932170 (View on PubMed)

Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006 Jul;19(3):449-90. doi: 10.1128/CMR.00054-05.

Reference Type BACKGROUND
PMID: 16847081 (View on PubMed)

Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, Hassall E, Macarthur C, Snyder J, Sherman PM; North American Society for Pediatric Gastroenterology and Nutrition. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr. 2000 Nov;31(5):490-7. doi: 10.1097/00005176-200011000-00007. No abstract available.

Reference Type BACKGROUND
PMID: 11144432 (View on PubMed)

Tam YH, Chan KW, To KF, Cheung ST, Mou JW, Pang KK, Wong YS, Sihoe JD, Lee KH. Impact of pediatric Rome III criteria of functional dyspepsia on the diagnostic yield of upper endoscopy and predictors for a positive endoscopic finding. J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):387-91. doi: 10.1097/MPG.0b013e31820e2026.

Reference Type BACKGROUND
PMID: 21415670 (View on PubMed)

Glickman JN, Antonioli DA. Gastritis. Gastrointest Endosc Clin N Am. 2001 Oct;11(4):717-40, vii.

Reference Type BACKGROUND
PMID: 11689363 (View on PubMed)

Kayacetin S, Guresci S. What is gastritis? What is gastropathy? How is it classified? Turk J Gastroenterol. 2014 Jun;25(3):233-47. doi: 10.5152/tjg.2014.7906.

Reference Type BACKGROUND
PMID: 25141310 (View on PubMed)

Other Identifiers

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EFOGIC

Identifier Type: -

Identifier Source: org_study_id