Evaluation of Novel Point of Care Hepatitis B Diagnostic Assays

NCT ID: NCT04289428

Last Updated: 2021-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-31

Study Completion Date

2022-10-31

Brief Summary

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Evaluation of novel point of care Hepatitis B diagnostic assays.

Detailed Description

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This study aims to evaluate the sensitivity of the following novel assays for evaluation of HBV infection and assessment of treatment eligibility;

* GeneXpert HBV DNA via Fingerstick testing,
* Dried Blood Spot based HBV DNA
* Point of care ALT.

Conditions

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Hepatitis B

Keywords

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Hepatitis B Diagnostics HBV DNA ALT Point of care Dried blood spot

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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A

Not currently on antiviral therapy for HBV and HBV DNA detectable

Xpert® HBV DNA fingerstick point of care assay

Intervention Type DIAGNOSTIC_TEST

Xpert® HBV DNA point of care assay from finger-stick whole blood

Point of Care ALT

Intervention Type DIAGNOSTIC_TEST

Point of Care ALT from finger-stick whole blood

Xpert® HBV DNA point of care assay from dried blood spot

Intervention Type DIAGNOSTIC_TEST

Xpert® HBV DNA point of care assay from dried blood spot

B

Stable on HBV antiviral therapy for at least 3 months with HBV DNA \< 20 IU/ml

Xpert® HBV DNA fingerstick point of care assay

Intervention Type DIAGNOSTIC_TEST

Xpert® HBV DNA point of care assay from finger-stick whole blood

Point of Care ALT

Intervention Type DIAGNOSTIC_TEST

Point of Care ALT from finger-stick whole blood

Xpert® HBV DNA point of care assay from dried blood spot

Intervention Type DIAGNOSTIC_TEST

Xpert® HBV DNA point of care assay from dried blood spot

Interventions

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Xpert® HBV DNA fingerstick point of care assay

Xpert® HBV DNA point of care assay from finger-stick whole blood

Intervention Type DIAGNOSTIC_TEST

Point of Care ALT

Point of Care ALT from finger-stick whole blood

Intervention Type DIAGNOSTIC_TEST

Xpert® HBV DNA point of care assay from dried blood spot

Xpert® HBV DNA point of care assay from dried blood spot

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. Have voluntarily signed the informed consent form.
2. 18 years of age or older.
3. HBsAg positive
4. Part A: Not currently on antiviral therapy for HBV and HBV DNA detectable OR Part B: Stable on HBV antiviral therapy for at least 3 months with HBV DNA \< 20 IU/ml

Exclusion Criteria

1\) Inability or unwillingness to provide informed consent or abide by the requirements of the study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kirby Institute

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gail Matthews, MBBS

Role: PRINCIPAL_INVESTIGATOR

Kirby Institute

Locations

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St. Vincent's Hospital Sydney

Darlinghurst, New South Wales, Australia

Site Status

Countries

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Australia

Other Identifiers

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VHCRP2001

Identifier Type: -

Identifier Source: org_study_id