Open-label, Flexible-dose Study of Vortioxetine in Patients With Depression in India

NCT ID: NCT04288895

Last Updated: 2022-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-02-20

Study Completion Date

2022-03-12

Brief Summary

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The purpose of this study is to evaluate the safety and tolerability of flexible doses of vortioxetine (5 - 20 mg/day) over a period of 12 weeks in patients with depression in India

Detailed Description

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Conditions

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Major Depressive Disorder

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Vortioxetine

flexible-dose

Group Type EXPERIMENTAL

Vortioxetine

Intervention Type DRUG

5 - 20 mg/day flexible-dose vortioxetine, tablets, orally

Interventions

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Vortioxetine

5 - 20 mg/day flexible-dose vortioxetine, tablets, orally

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* The patient has a Major Depressive Episode (MDE), is diagnosed with Major Depressive Disorder (MDD) according to DSM-5® and would benefit from pharmacological treatment with vortioxetine. The current MDE should be confirmed using the Mini International Neuropsychiatric Interview (MINI).
* The patient has a CGI-S ≥4 at screening.

Exclusion Criteria

* The patient has a significant risk of suicide according to investigator's clinical judgment or has made an actual suicide attempt in the period of 6 months prior to screening.
* The patient previously received vortioxetine.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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H. Lundbeck A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Email contact via H. Lundbeck A/S

Role: STUDY_DIRECTOR

[email protected]

Locations

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Ratandeep Multispecialty Hospital (IN1002)

Ahmedabad, Gujarat, India

Site Status

MITR Foundation 1 (IN1013)

Ahmedabad, Gujarat, India

Site Status

BJ Medical College and Civil Hospital (IN028)

Ahmedabad, Gujarat, India

Site Status

Shree Hatkesh Health Foundation (IN1016)

Jūnāgadh, Gujarat, India

Site Status

Nagecha Hospital, Creative Chamber (IN1015)

Rajkot, Gujarat, India

Site Status

Divyam Clinic (IN1025)

Surat, Gujarat, India

Site Status

GMERS Medical College and Hospital,Department of Psychiatry (IN1004)

Vadodara, Gujarat, India

Site Status

People Tree Hospitals (IN1027)

Bengaluru, Karnataka, India

Site Status

Vinaya Hospital & Research Centre (IN1007)

Mangalore, Karnataka, India

Site Status

Mangala Hospital & Mangala Kidney Foundation (IN1006)

Mangalore, Karnataka, India

Site Status

K. S. Hegde Medical Academy (IN1003)

Mangalore, Karnataka, India

Site Status

Department of Psychiatry K R Hospital Mysore Medical College and Research Institute (IN1020)

Mysuru, Karnataka, India

Site Status

IQRAA International Hospital & Research Centre (IN030)

Kozhikode, Kerala, India

Site Status

Society for Psychiatric Update and Research, Shanti Nursing Home (IN1008)

Aurangabad, Maharashtra, India

Site Status

Arneja Heart and Multispeciality Hospital (IN1022)

Nagpur, Maharashtra, India

Site Status

Central Institute of Behavioural Sciences (IN1019)

Nagpur, Maharashtra, India

Site Status

Chopda Medicare & Research Centre (IN023)

Nashik, Maharashtra, India

Site Status

Lata Mangeshkar Medical Foundation's (IN1001)

Pune, Maharashtra, India

Site Status

Oyster and Pearl Hospital (IN1014)

Pune, Maharashtra, India

Site Status

Dayanand Medical College and Hospital (IN024)

Ludhiana, Punjab, India

Site Status

ASHA hospital (IN1018)

Hyderabad, Telangana, India

Site Status

Deva Institute of Healthcare and Research PVT ltd. (IN1005)

Varanasi, Uttar Pradesh, India

Site Status

Institute of Post Graduate Medical Education and Research (IN1026)

Kolkata, West Bengal, India

Site Status

Maharaja Agarsen Hospital (IN1021)

Delhi, , India

Site Status

Countries

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India

References

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Adair M, Bose R, Schmidt SN. Safety and effectiveness of vortioxetine in patients with major depressive disorder in a real-life clinical setting in India: results from an interventional, flexible-dose study. Curr Med Res Opin. 2024 Sep;40(9):1637-1645. doi: 10.1080/03007995.2024.2382773. Epub 2024 Aug 7.

Reference Type DERIVED
PMID: 39110846 (View on PubMed)

Other Identifiers

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17775A

Identifier Type: -

Identifier Source: org_study_id

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