Open-Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis

NCT ID: NCT04286607

Last Updated: 2025-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

333 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-02-12

Study Completion Date

2024-01-22

Brief Summary

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This study will assess the safety and efficacy of ARQ-151 cream applied once a day for 24 weeks by subjects with chronic plaque psoriasis

Detailed Description

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This is an open-label study in which ARQ-151 cream is applied once daily x 24 weeks to subjects with psoriasis

Conditions

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Chronic Plaque Psoriasis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ARQ-151 Cream 0.3%

Group Type EXPERIMENTAL

Topical roflumilast

Intervention Type DRUG

Active treatment

Interventions

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Topical roflumilast

Active treatment

Intervention Type DRUG

Other Intervention Names

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ARQ-151 Cream 0.3%

Eligibility Criteria

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Inclusion Criteria

* Participants legally competent to sign and give informed consent or informed consent of legal guardian, and, if age appropriate, assent by the subject, as required by local laws
* Males and females ages 2 years and older (inclusive)
* Subjects with chronic plaque psoriasis who meet eligibility criteria and:

1. Successfully completed a prior ARQ-151 cream study in psoriasis (Cohort 1) or
2. Are naïve to treatment with ARQ-151 cream (Cohort 2)
* Females of childbearing potential (FOCBP) must have a negative pregnancy test at all study visits. In addition, sexually active FOCBP must agree to use at least one form of highly effective contraception throughout the trial.

Exclusion Criteria

* Subjects who experienced an ARQ-151 treatment-related AE or a serious AE (SAE) that precluded further treatment with ARQ-151 cream in a prior ARQ-151 cream study.
* Planned excessive exposure of treated area(s) to either natural or artificial sunlight, tanning bed or other LED.
* Females who are pregnant, wishing to become pregnant during the study, or are breast-feeding.
* Subjects with any serious medical condition or laboratory abnormality that would prevent study participation or place the subject at significant risk, as determined by the Investigator.
* Subjects with a history of chronic alcohol or drug abuse within 6 months of initiation of investigational product.
* Subjects who are unable to communicate, read or understand the local language, or who display another condition, which in the Investigator's opinion, makes them unsuitable for clinical study participation.
Minimum Eligible Age

2 Years

Maximum Eligible Age

11 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Arcutis Biotherapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David Berk, MD

Role: STUDY_DIRECTOR

Arcutis Biotherapeutics, Inc.

Locations

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Arcutis Biotherapeutics Clinical Site 203

Scottsdale, Arizona, United States

Site Status

Arcutis Biotherapeutics Clinical Site 239

Beverly Hills, California, United States

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Arcutis Biotherapeutics Clinical Site 127

Encinitas, California, United States

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Arcutis Biotherapeutics Clinical Site 225

Encino, California, United States

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Arcutis Biotherapeutics Clinical Site 509

Fountain Valley, California, United States

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Arcutis Biotherapeutics Clinical Site 112

Fremont, California, United States

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Arcutis Biotherapeutics Clinical Site 120

Irvine, California, United States

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Arcutis Biotherapeutics Clinical Site 508

Los Angeles, California, United States

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Arcutis Biotherapeutics Clinical Site 511

Rancho Santa Margarita, California, United States

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Arcutis Biotherapeutics Clinical Site 123

San Diego, California, United States

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Arcutis Biotherapeutics Clinical Site 220

San Diego, California, United States

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Arcutis Biotherapeutics Clinical Site 136

San Francisco, California, United States

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Arcutis Biotherapeutics Clinical Site 208

Santa Monica, California, United States

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Arcutis Biotherapeutics Clinical Site 215

Santa Monica, California, United States

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Arcutis Biotherapeutics Clinical Site 223

Boynton Beach, Florida, United States

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Arcutis Biotherapeutics Clinical Site 237

DeLand, Florida, United States

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Arcutis Biotherapeutics Clinical Site 118

Delray Beach, Florida, United States

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Arcutis Biotherapeutics Clinical Site 202

Hialeah, Florida, United States

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Arcutis Biotherapeutics Clinical Site 228

Largo, Florida, United States

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Arcutis Biotherapeutics Clinical Site 131

Miami, Florida, United States

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Arcutis Biotherapeutics Clinical Site 201

North Miami Beach, Florida, United States

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Arcutis Biotherapeutics Clinical Site 137

Ocala, Florida, United States

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Arcutis Biotherapeutics Clinical Site 105

Sanford, Florida, United States

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Arcutis Biotherapeutics Clinical Site 209

Sweetwater, Florida, United States

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Arcutis Clinical Site 602

Boise, Idaho, United States

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Arcutis Biotherapeutics Clinical Site 114

Plainfield, Illinois, United States

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Arcutis Biotherapeutics Clinical Site 102

Rolling Meadows, Illinois, United States

Site Status

Arcutis Biotherapeutics Clinical Site 214

Indianapolis, Indiana, United States

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Arcutis Biotherapeutics Clinical Site 217

Louisville, Kentucky, United States

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Arcutis Biotherapeutics Clinical Site 111

Baton Rouge, Louisiana, United States

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Arcutis Biotherapeutics Clinical Site 211

Lake Charles, Louisiana, United States

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Arcutis Biotherapeutics Clinical Site 213

Metairie, Louisiana, United States

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Arcutis Biotherapeutics Clinical Site 224

New Orleans, Louisiana, United States

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Arcutis Biotherapeutics Clinical Site 125

Rockville, Maryland, United States

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Arcutis Biotherapeutics Clinical Site 138

Rockville, Maryland, United States

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Arcutis Biotherapeutics Clinical Site 101

Brighton, Massachusetts, United States

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Arcutis Biotherapeutics Clinical Site 116

Clinton Township, Michigan, United States

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Arcutis Biotherapeutics Clinical Site 212

Detroit, Michigan, United States

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Arcutis Biotherapeutics Clinical Site 216

Fridley, Minnesota, United States

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Arcutis Biotherapeutics Clinical Site 227

Saint Joseph, Missouri, United States

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Arcutis Biotherapeutics Clinical Site 219

Las Vegas, Nevada, United States

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Arcutis Biotherapeutics Clinical Site 231

Las Vegas, Nevada, United States

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Arcutis Biotherapeutics Clinical Site 139

Reno, Nevada, United States

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Arcutis Biotherapeutics Clinical Site 240

Reno, Nevada, United States

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Arcutis Biotherapeutics Clinical Site 236

Portsmouth, New Hampshire, United States

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Arcutis Biotherapeutics Clinical Site 129

East Windsor, New Jersey, United States

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Arcutis Biotherapeutics Clinical Site 121

New York, New York, United States

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Arcutis Biotherapeutics Clinical Site 130

Rochester, New York, United States

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Arcutis Biotherapeutics Clinical Site 108

Stony Brook, New York, United States

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Arcutis Biotherapeutics Clinical Site 115

High Point, North Carolina, United States

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Arcutis Biotherapeutics Clinical Site 124

Fairborn, Ohio, United States

Site Status

Arcutis Biotherapeutics Clinical Site 222

Oklahoma City, Oklahoma, United States

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Arcutis Biotherapeutics Clinical Site 134

Oklahoma City, Oklahoma, United States

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Arcutis Biotherapeutics Clinical Site 229

Broomall, Pennsylvania, United States

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Arcutis Biotherapeutics Clinical Site 128

Duncansville, Pennsylvania, United States

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Arcutis Biotherapeutics Clinical Site 113

Exton, Pennsylvania, United States

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Arcutis Biotherapeutics Clinical Site 135

Pittsburgh, Pennsylvania, United States

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Arcutis Biotherapeutics Clinical Site 233

Knoxville, Tennessee, United States

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Arcutis Biotherapeutics Clinical Site 221

Murfreesboro, Tennessee, United States

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Arcutis Biotherapeutics Clinical Site 206

Arlington, Texas, United States

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Arcutis Biotherapeutics Clinical Site 104

College Station, Texas, United States

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Arcutis Biotherapeutics Clinical Site 119

Dallas, Texas, United States

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Arcutis Biotherapeutics Clinical Site 519

Frisco, Texas, United States

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Arcutis Biotherapeutics Clinical Site 238

Houston, Texas, United States

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Arcutis Biotherapeutics Clinical Site 110

San Antonio, Texas, United States

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Arcutis Biotherapeutics Clinical Site 117

San Antonio, Texas, United States

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Arcutis Biotherapeutics Clinical Site 210

West Jordan, Utah, United States

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Arcutis Biotherapeutics Clinical Site 230

Richmond, Virginia, United States

Site Status

Arcutis Biotherapeutics Clinical Site 132

Calgary, Alberta, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 207

Surrey, British Columbia, Canada

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Arcutis Biotherapeutics Clinical Site 226

Surrey, British Columbia, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 232

Winnepeg, Manitoba, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 234

Fredericton, New Brunswick, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 205

Ajax, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 218

Barrie, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 103

London, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 133

Mississauga, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 140

Ottawa, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 109

Peterborough, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 235

Toronto, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 106

Waterloo, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 204

Windsor, Ontario, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 107

Montreal, Quebec, Canada

Site Status

Arcutis Biotherapeutics Clinical Site 126

Québec, Quebec, Canada

Site Status

Arcutis Clinical Site 601

Santo Domingo, , Dominican Republic

Site Status

Countries

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United States Canada Dominican Republic

Other Identifiers

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ARQ-151-306

Identifier Type: -

Identifier Source: org_study_id

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