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Physical Activity, Meal Composition, and RMR Among Children Adolescent and Adults

NCT ID: NCT04284683

Last Updated: 2020-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-01

Study Completion Date

2020-09-29

Brief Summary

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Resting metabolic rate (RMR) is the amount of energy the body uses at rest, and accounts for 60%-70% of daily energy expenditure. Although measured at rest, RMR is strongly influenced by physical activity because the increased metabolic rate during exercise is partially carried over even when exercise stops. Therefore, persons who are physically active maintain higher RMR and less body fat than do sedentary controls. It is well known that high energy intake stimulates whereas caloric restriction reduces RMR. Food thermogenesis corresponds to approximately 10% of daily energy expenditure. Diet-induced thermogenesis is greater on a high protein and carbohydrate diet than on a fat diet. Other factors the affect RMR are age (RMR tends to decline progressively over the life span) and body composition (lean body mass is regarded as the main determinant of RMR). However, the research regarding the effect of a specific combination of macronutrients and exercise on RMR is scarce.

Therefore, the aim of the current study is to assess the combined effect of a meal composition and physical activity on RMR in normal weight and overweight children, adolescents and adults.

Detailed Description

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One hundred (100) healthy volunteers, 50 normal weight (NW) and 50 overweight (OW), age 6-30 will be recruited for the current study. All participants and/or their parents will sign informed consent prior to their participation. Participants will visit the clinic 4 times, with a week's difference between them. Participants will arrive at the clinic after 12 hours of fasting and avoiding physical activity for 14 hours. During the first visit, their RMR will be measured, and 15min later they will perform 60 min of aerobic training, and 15 minutes later they will be asked to drink 300ml of water, followed by a second RMR test. In the consecutive visits they will follow the same routine without the first RMR test, and drink either carbohydrate enriched shake, protein enriched shake or fat enriched shake; in a random order.

Conditions

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Obesity

Keywords

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RMR Macro nutrients Exercise

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Normal and overweight participants

Healthy males and female, age 6 to 30. BMI range for participants age 6 to 18 is between 5th percentile to 85th percentile, overweight BMI between the 85 and 95th percentile, and obese, above the 95th percentile.

BMI range for participants age 18 to 30 is between 18.5 to 24.9 for normal weight, 25-30 for overweight and above 30 for obese.

Group Type EXPERIMENTAL

DRINK - Water, Protein, Fat, Carbohydrate

Intervention Type OTHER

Following exercise participants will consume a drink (with different composition in each visit) and than RMR will be evaluated.

Interventions

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DRINK - Water, Protein, Fat, Carbohydrate

Following exercise participants will consume a drink (with different composition in each visit) and than RMR will be evaluated.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Ages 6-30 years.
* Normal weight and over weight participants

Exclusion Criteria

* Elite athletes
* Participants with physical limitations concerning strenuous physical activity.
Minimum Eligible Age

6 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Meir Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Dan Nemet, MD

Prof. Dan Nemet

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dan Nemet, MD

Role: PRINCIPAL_INVESTIGATOR

Meir Medical Center

Locations

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'Meir children's sport and health center'

Kfar Saba, , Israel

Site Status

Meir Medical Center

Kfar Saba, , Israel

Site Status

Countries

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Israel

Other Identifiers

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MeirMc0173-18CTIL

Identifier Type: -

Identifier Source: org_study_id