Monitoring of Cerebral Autoregulation in Pediatric ECMO (ECMOX 1)
NCT ID: NCT04282525
Last Updated: 2020-02-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
30 participants
OBSERVATIONAL
2018-06-01
2019-06-01
Brief Summary
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Detailed Description
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Measurements: A correlation coefficient between the variations of regional cerebral oxygen saturation (rScO2) as a surrogate of cerebral blood flow and the variations of arterial blood pressure (ABP) is calculated as an index of autoregulation (cerebral oxygenation index (COx), ICM+ software®). CA is monitored either on left (COxl) or both sides. A COx \> 0.3 is considered as critical. Neurological outcome is assessed by the onset of an acute neurologic event (ANE) during the ECMO run.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Interventions
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ECMO for hemodynamic or respiratory indication
ECMO for hemodynamic or respiratory indication
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
1 Day
18 Years
ALL
No
Sponsors
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Istituto Giannina Gaslini
OTHER
University of Cambridge
OTHER
Nantes University Hospital
OTHER
Responsible Party
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Locations
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University Hospital
Nantes, Loire-Atlantique, France
Countries
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References
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Joram N, Beqiri E, Pezzato S, Moscatelli A, Robba C, Liet JM, Chenouard A, Bourgoin P, Czosnyka M, Leger PL, Smielewski P. Impact of Arterial Carbon Dioxide and Oxygen Content on Cerebral Autoregulation Monitoring Among Children Supported by ECMO. Neurocrit Care. 2021 Oct;35(2):480-490. doi: 10.1007/s12028-021-01201-8. Epub 2021 Mar 9.
Joram N, Beqiri E, Pezzato S, Moscatelli A, Robba C, Liet JM, Chenouard A, Bourgoin P, Czosnyka M, Leger PL, Smielewski P. Continuous Monitoring of Cerebral Autoregulation in Children Supported by Extracorporeal Membrane Oxygenation: A Pilot Study. Neurocrit Care. 2021 Jun;34(3):935-945. doi: 10.1007/s12028-020-01111-1. Epub 2020 Oct 8.
Other Identifiers
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ECMOX1
Identifier Type: -
Identifier Source: org_study_id
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