High-impact Exercise in Adults With Crohn's Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-03-31

Study Completion Date

2021-10-31

Brief Summary

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Crohn's disease increases the risk of poor musculoskeletal health, as the inflammatory disease process directly inhibits regulatory pathways involved in bone and muscle formation and maintenance. The negative effects of disease on muscle-bone health are compounded by poor nutritional status, vitamin d deficiency, prolonged exposure to glucocorticoid therapy, and reduced physical activity. Modern, steroid sparing therapies are successful at inducing clinical remission in terms of inflammation, however they have limited effect in remedying observed muscle-bone deficits. Subsequently, patients with Crohn's disease are at increased lifelong risk of pathological fractures and osteoporosis. Novel adjunctive therapies are therefore required to complement pharmacological treatments and target muscle-bone deficits, which are responsible for significant disease burden in Crohn's.

High-impact exercise may be a useful additional therapy for patients with Crohn's disease, as the mechanical strains produced during this type of exercise, through large magnitude muscular contractions and ground reaction forces, can promote bone formation and gains in muscle mass. There have been no previous studies assessing the effects of high impact exercise in Crohn's disease, so it is unknown if this type of exercise is safe and feasible in this population. The aim of this study is to assess the feasibility of high-impact exercise for improving markers of bone and muscle health in adults with Crohn's disease, and compare the effects of exercise with a group of healthy age and sex matched controls.

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Detailed Description

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Conditions

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Crohn Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Case control model

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Crohn's Disease

Twelve week jumping based exercise intervention

Group Type EXPERIMENTAL

High-impact exercise intervention

Intervention Type OTHER

* Twelve-week high-impact exercise intervention
* Majority home based sessions, some supervised sessions
* Three exercise sessions per week
* Between 50 - 100 jumps per session
* Progressive jumping exercises to increase mechanical loading

Acute response to high-impact exercise

Intervention Type OTHER

* First session of twelve-week high-impact exercise session used to assess the acute physiological response to one session of high-impact exercise in both Crohn's disease and healthy controls
* One supervised session of high-impact exercise
* Bloods to assess acute inflammatory and bone turnover response post-exercise

Controls

Age and sex matched controls will undertake the same twelve week intervention for active comparison between groups

Group Type ACTIVE_COMPARATOR

High-impact exercise intervention

Intervention Type OTHER

* Twelve-week high-impact exercise intervention
* Majority home based sessions, some supervised sessions
* Three exercise sessions per week
* Between 50 - 100 jumps per session
* Progressive jumping exercises to increase mechanical loading

Acute response to high-impact exercise

Intervention Type OTHER

* First session of twelve-week high-impact exercise session used to assess the acute physiological response to one session of high-impact exercise in both Crohn's disease and healthy controls
* One supervised session of high-impact exercise
* Bloods to assess acute inflammatory and bone turnover response post-exercise

Interventions

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High-impact exercise intervention

* Twelve-week high-impact exercise intervention
* Majority home based sessions, some supervised sessions
* Three exercise sessions per week
* Between 50 - 100 jumps per session
* Progressive jumping exercises to increase mechanical loading

Intervention Type OTHER

Acute response to high-impact exercise

* First session of twelve-week high-impact exercise session used to assess the acute physiological response to one session of high-impact exercise in both Crohn's disease and healthy controls
* One supervised session of high-impact exercise
* Bloods to assess acute inflammatory and bone turnover response post-exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Crohn's disease diagnosed at least six months ago
* Stable medication for at least four weeks
* Disease in remission, or mildly/moderately active according to Harvey Bradshaw Index score
* Currently undertaking \<2 hours of structured exercise per week
* Able to mobilise and exercise independently
* Able to provide written informed consent

Exclusion Criteria

* Surgery \<12 weeks or planned surgery during intervention period
* Comorbidity known to affect muscle / bone
* Contraindication to high-impact exercise
* Pregnancy or planned pregnancy during intervention period
* BMI \>40 kg/m2 (or body mass \>120kg)

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes