Corneal Densitometry Changes With Adenoviral SEI

NCT ID: NCT04267991

Last Updated: 2020-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

63 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-01

Study Completion Date

2020-04-15

Brief Summary

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Adenoviral Sub epithelial infiltrates (SEI) affect ocular function.They lead to reduced vision, photophobia, glare, halos, and foreign body sensation.

Detailed Description

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first group of patients were treated with 0.03 % tacrolimus ointment twice daily for 6 months.S econd group underwent transepithelial PTK for subepithelial infiltrates. Baseline and post-treatment full ophthalmic examination was done.

Conditions

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Corneal Disease

Keywords

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adenoviral infiltrates PTK tacrolimus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Tacrolimus

Patients were treated with 0.03 % tacrolimus ointment twice daily for 6 months.

Tacrolimus ointment

Intervention Type DRUG

Patients were treated with 0.03 % tacrolimus ointment twice daily for 6 months.

Phototherapeutic Keratectomy

Patients underwent transepithelial PTK for subepithelial infiltrates.

phototherapeutic keratectomy

Intervention Type PROCEDURE

Patients underwent transepithelial PTK for subepithelial infiltrates.

Control

patients received only artificial tears eyedrop

No interventions assigned to this group

Interventions

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Tacrolimus ointment

Patients were treated with 0.03 % tacrolimus ointment twice daily for 6 months.

Intervention Type DRUG

phototherapeutic keratectomy

Patients underwent transepithelial PTK for subepithelial infiltrates.

Intervention Type PROCEDURE

Other Intervention Names

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Protopic ointment

Eligibility Criteria

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Inclusion Criteria

* adenoviral SEI

Exclusion Criteria

* Other corneal diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Benha University

OTHER

Sponsor Role lead

Responsible Party

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Tarek Roshdy mohamed Mahgoub ELhamaky

Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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TAREK R ELHAMAKY

Role: PRINCIPAL_INVESTIGATOR

Benha university faculty of medicine

Locations

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INMC

Abu Dhabi, , United Arab Emirates

Site Status

Countries

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United Arab Emirates

References

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Elhamaky TR. Pentacam corneal densitometry-guided treatment of adenoviral corneal subepithelial infiltrates: a comparative study between transepithelial phototherapeutic keratectomy and topical tacrolimus. Int Ophthalmol. 2021 Jan;41(1):67-77. doi: 10.1007/s10792-020-01553-8. Epub 2020 Aug 27.

Reference Type DERIVED
PMID: 32852646 (View on PubMed)

Other Identifiers

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Hamaky5

Identifier Type: -

Identifier Source: org_study_id