Trial Outcomes & Findings for High-density EEG in Neurological Disorders (NCT NCT04266041)
NCT ID: NCT04266041
Last Updated: 2025-12-12
Results Overview
The frequency of detecting interictal spikes in HD-EEG The distance between the source location determined by electrical source imaging and the spike locations determined by SEEG studies
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
122 participants
Primary outcome timeframe
From 30-60 min HD-EEG recording, pre-operatively
Results posted on
2025-12-12
Participant Flow
Participant milestones
| Measure |
High-density EEG Localization in Epilepsy
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Healthy Controls
High-density EEG will be used for brain localization in healthy controls
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
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|---|---|---|---|---|---|
|
Overall Study
STARTED
|
95
|
12
|
1
|
4
|
7
|
|
Overall Study
COMPLETED
|
95
|
12
|
1
|
4
|
7
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
We did not collect age information for the healthy control subjects for the purposes of protecting subjects' personal information.
Baseline characteristics by cohort
| Measure |
High-density EEG Localization in Epilepsy
n=95 Participants
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Healthy Controls
n=12 Participants
High-density EEG will be used for brain localization in healthy controls
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
n=1 Participants
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
n=4 Participants
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
n=7 Participants
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
Total
n=119 Participants
Total of all reporting groups
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|---|---|---|---|---|---|---|
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Age, Continuous
|
37.55 years
STANDARD_DEVIATION 13.19 • n=95 Participants • We did not collect age information for the healthy control subjects for the purposes of protecting subjects' personal information.
|
—
|
72 years
STANDARD_DEVIATION 0 • n=1 Participants • We did not collect age information for the healthy control subjects for the purposes of protecting subjects' personal information.
|
42.75 years
STANDARD_DEVIATION 10.44 • n=4 Participants • We did not collect age information for the healthy control subjects for the purposes of protecting subjects' personal information.
|
74.38 years
STANDARD_DEVIATION 10.42 • n=7 Participants • We did not collect age information for the healthy control subjects for the purposes of protecting subjects' personal information.
|
40.59 years
STANDARD_DEVIATION 16.22 • n=107 Participants • We did not collect age information for the healthy control subjects for the purposes of protecting subjects' personal information.
|
|
Sex: Female, Male
Female
|
38 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
3 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
2 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
1 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
44 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Sex: Female, Male
Male
|
57 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
9 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
1 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
2 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
6 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
75 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
0 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
95 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
5 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
1 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
4 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
7 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
112 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
7 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
7 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Race (NIH/OMB)
Asian
|
1 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
1 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Race (NIH/OMB)
Black or African American
|
1 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
1 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Race (NIH/OMB)
White
|
92 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
4 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
1 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
4 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
7 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
108 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
8 Participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
0 Participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
9 Participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
|
Region of Enrollment
United States
|
95 participants
n=95 Participants • 3 patients did the study twice with different subject IDs.
|
12 participants
n=12 Participants • 3 patients did the study twice with different subject IDs.
|
1 participants
n=1 Participants • 3 patients did the study twice with different subject IDs.
|
4 participants
n=4 Participants • 3 patients did the study twice with different subject IDs.
|
6 participants
n=7 Participants • 3 patients did the study twice with different subject IDs.
|
119 participants
n=119 Participants • 3 patients did the study twice with different subject IDs.
|
PRIMARY outcome
Timeframe: From 30-60 min HD-EEG recording, pre-operativelyPopulation: 95 adult patients were enrolled in this study. Five subjects have already got neurostimulator (RNS or DBS) implanted before the study, of whom the HD-EEG data were excluded for further analysis. Two other subjects' recordings were excluded due to excessive electrical noise or faulty bulk connector. Therefore, 87 subjects with decent resting-state HD-EEG recordings were processed for spike detection. Interictal spikes were detected in the HD-EEG recordings of nearly 60% of subjects (n = 52).
The frequency of detecting interictal spikes in HD-EEG The distance between the source location determined by electrical source imaging and the spike locations determined by SEEG studies
Outcome measures
| Measure |
High-density EEG Localization in Epilepsy
n=87 Participants
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
|---|---|---|---|---|
|
Localizing Brain Regions That Generate Interictal Spikes
|
52 Participants
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: At baseline for approximately 60 - 90 minutesPopulation: healthy control only had sensory and language tasks. Tumor patient only had motor and sensory tasks, also underwent resting-state recording to localize lesion. Peripheral nerve patients only had motor and sensory tasks. Stroke patients only had electrical impedance study to localize the lesion.
Localize brain functions using high-density EEG recordings
Outcome measures
| Measure |
High-density EEG Localization in Epilepsy
n=12 Participants
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
n=1 Participants
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
n=4 Participants
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
n=7 Participants
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
|---|---|---|---|---|
|
Localize Brain Functions in Patients and Healthy Controls
High-gamma for language
|
12 Participants
|
—
|
—
|
—
|
|
Localize Brain Functions in Patients and Healthy Controls
Alpha for motor
|
—
|
1 Participants
|
0 Participants
|
—
|
|
Localize Brain Functions in Patients and Healthy Controls
Somatosensory evoked potential
|
1 Participants
|
1 Participants
|
0 Participants
|
—
|
|
Localize Brain Functions in Patients and Healthy Controls
Lesion
|
—
|
1 Participants
|
—
|
4 Participants
|
SECONDARY outcome
Timeframe: At baseline for approximately 60 - 90 minutesPopulation: all normal subjects
Localize brain areas involved in language using high-density EEG recordings
Outcome measures
| Measure |
High-density EEG Localization in Epilepsy
n=12 Participants
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
|---|---|---|---|---|
|
Localize Brain Areas Involved in Language
Feasible to complete the language task
|
12 Participants
|
—
|
—
|
—
|
|
Localize Brain Areas Involved in Language
high-gamma activity localized to suspected language area
|
12 Participants
|
—
|
—
|
—
|
SECONDARY outcome
Timeframe: At baseline for approximately 60 - 90 minutesLocalize brain areas involved in movement using high-density EEG recordings
Outcome measures
| Measure |
High-density EEG Localization in Epilepsy
n=1 Participants
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
n=4 Participants
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
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Localize Brain Areas Involved in Movement
Tolerated motor task
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1 Participants
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4 Participants
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—
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—
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Localize Brain Areas Involved in Movement
Alpha band activity localized to motor area
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1 Participants
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0 Participants
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—
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—
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SECONDARY outcome
Timeframe: At baseline for approximately 60 - 90 minutesLocalize brain areas involved in sensation using high-density EEG recordings
Outcome measures
| Measure |
High-density EEG Localization in Epilepsy
n=12 Participants
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
n=1 Participants
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
n=4 Participants
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
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|---|---|---|---|---|
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Localize Brain Areas Involved in Sensation
Tolerated Sensory task
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12 Participants
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1 Participants
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4 Participants
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—
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Localize Brain Areas Involved in Sensation
Somatosensory evoked potential captured
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1 Participants
|
1 Participants
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0 Participants
|
—
|
SECONDARY outcome
Timeframe: At baseline for approximately 60 - 90 minutesLocalize brain areas associated with lesions using high-density EEG recordings
Outcome measures
| Measure |
High-density EEG Localization in Epilepsy
n=1 Participants
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
n=7 Participants
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
|---|---|---|---|---|
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Localize Brain Areas Associated With Lesions
Tolerated resting-state recording
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1 Participants
|
7 Participants
|
—
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—
|
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Localize Brain Areas Associated With Lesions
Abnormality localized
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1 Participants
|
4 Participants
|
—
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—
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Adverse Events
High-density EEG Localization in Epilepsy
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
High-density EEG Localization in Healthy Controls
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
High-density EEG Localization in Tumor Patients
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
High-density EEG Localization in Peripheral Nerve Patients
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
High-density EEG Localization in Stroke Patients
Serious events: 2 serious events
Other events: 1 other events
Deaths: 1 deaths
Serious adverse events
| Measure |
High-density EEG Localization in Epilepsy
n=95 participants at risk
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Healthy Controls
n=12 participants at risk
High-density EEG will be used for brain localization in healthy controls
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
n=1 participants at risk
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
n=4 participants at risk
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
n=7 participants at risk
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
|---|---|---|---|---|---|
|
Vascular disorders
Death
|
0.00%
0/95 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/12 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/1 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/4 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
14.3%
1/7 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
|
Psychiatric disorders
Suicide attempt
|
0.00%
0/95 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/12 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/1 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/4 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
14.3%
1/7 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
Other adverse events
| Measure |
High-density EEG Localization in Epilepsy
n=95 participants at risk
High-density EEG will be used for brain localization in epilepsy patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Healthy Controls
n=12 participants at risk
High-density EEG will be used for brain localization in healthy controls
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Tumor Patients
n=1 participants at risk
High-density EEG will be used for brain localization in tumor patients
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Peripheral Nerve Patients
n=4 participants at risk
High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
High-density EEG Localization in Stroke Patients
n=7 participants at risk
High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density electroencephalogram (HD-EEG): This study will focus on obtaining a special type of high-density scalp electroencephalography (HD-EEG) recordings in patients with neurological disorders (i.e., epilepsy, brain tumor, stroke, etc.) and appropriately matched controls. HD-EEG is a scalp EEG which uses up to 256 channels compared to the standard 21 channels used for routine clinical applications. The reason for using more channels to record is for more precise localization of epileptogenic foci and/or more precise mapping of brain functions. This type of EEG requires the use of patient's own MRI scan to precisely localize activity. Therefore, all patients and controls getting an HD-EEG will require a structural MRI scan.
|
|---|---|---|---|---|---|
|
Skin and subcutaneous tissue disorders
Tingling of left scalp
|
0.00%
0/95 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/12 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/1 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
0.00%
0/4 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
14.3%
1/7 • Number of events 1 • Adverse event data were collected from the consent through the end of participation for each subject (typically one day).
Adverse event collection for each participant was done from the time of consent through the end of study participation.
|
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place