An AHEI Dietary Intervention to Reduce Pain in Women With Endometriosis

NCT ID: NCT04259788

Last Updated: 2025-04-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

109 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-24

Study Completion Date

2026-02-28

Brief Summary

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The investigators are conducting this study to examine if a healthy diet based on the Alternative Healthy Eating Index (AHEI) influences pain symptoms, quality of life, and inflammatory markers measured in blood samples in women with endometriosis who are currently experiencing pain symptoms.

Detailed Description

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Conditions

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Endometriosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Intervention

The intervention group will receive in-person dietary counseling from a registered dietitian to help participants consume a diet that is consistent the AHEI dietary guidelines. Participants in this arm will be asked to consume this diet for a 12-week period and discontinue any vitamin or supplement intake during this time. During the first 4 weeks 2 meals and 1 snack/day will be shipped to the participant. During the last 8 weeks of the intervention, the study will provide the participants with a 14-day meal plan (3 meals and 2 snacks) that adheres to the AHEI maximum score criteria to help facilitate adherence to the diet.

Group Type EXPERIMENTAL

AHEI diet

Intervention Type OTHER

Main intervention is the consumption of an AHEI diet for 12 weeks.

Control

Participants in this arm will not receive the dietary intervention.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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AHEI diet

Main intervention is the consumption of an AHEI diet for 12 weeks.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Female
* Aged 18-45
* Laparoscopically-confirmed endometriosis
* Premenopausal (at least one period in the past 6 months)
* VAS pain score of at least 7 out of 10 in the previous 3 months
* Score below 75 on the AHEI-2010

Exclusion Criteria

* Postmenopausal
* Pregnant
* Have had a hysterectomy or oophorectomy
* Have chronic illnesses that are known to affect gastrointestinal absorption of nutrients (celiac disease, Crohn's disease, ulcerative colitis, or cystic fibrosis)
* A history of kidney stones, cancer (except basal cell carcinoma), or diabetes
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Nursing Research (NINR)

NIH

Sponsor Role collaborator

Fred Hutchinson Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Holly Harris

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Holly Harris

Role: PRINCIPAL_INVESTIGATOR

Fred Hutchinson Cancer Center

Locations

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Fred Hutchinson Cancer Research Center

Seattle, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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8772

Identifier Type: OTHER

Identifier Source: secondary_id

R01NR017951

Identifier Type: NIH

Identifier Source: secondary_id

View Link

RG1004314

Identifier Type: -

Identifier Source: org_study_id

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