Characterization of Corticospinal Excitability During Progressive Skin Cooling

NCT ID: NCT04253730

Last Updated: 2022-12-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-08-22
• Study Completion Date: 2022-06-01

Brief Summary

This study characterizes the changes in corticospinal excitability that accompany basic cold stress via skin cooling that result in reduced skin or core temperature and shivering.

Detailed Description

Cold stress is known to impair both fine and gross motor movement. Reductions in performance may have life threatening consequences in survival situations where maintenance of muscle control is necessary. Much of the effects cooling has on muscle performance is directly due to its effects on muscle tissue itself, whereas less is known about the effects on the central nervous system. Therefore, the purpose of the study was to characterize corticospinal excitability that accompanies basic cold stress via progressive skin cooling, resulting in reductions in skin (Tsk) or core (Tco) temperature and shivering.

Conditions

Hypothermia Due to Cold Environment

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Control Condition

Subjects will sit at rest wearing a liquid perfused suit containing thermoneutral water for 60 min. The suit will not be turned on during this period.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Cold Condition

Subjects will be cooled for 60-90 min at \~ 4-10°C using a liquid perfused suit. Subjects will then be rewarmed for 30 min at \~ 41°C using the liquid perfused suit.

Group Type: EXPERIMENTAL

Cold Stress

Intervention Type: OTHER

60-90 mins of cooling via a liquid perfused suit circulating \~4-10°C liquid.

Interventions

Cold Stress

60-90 mins of cooling via a liquid perfused suit circulating \~4-10°C liquid.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy adult
• Right Handed
• Pass Magnetic Stimulation Safety Checklist
• Pass Medical Screening Questionnaire

Exclusion Criteria

• Left Handed
• Any adverse responses to cold exposure (Raynaud's Syndrome)
• Cardiorespiratory Disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Manitoba

OTHER

Sponsor Role: lead

Responsible Party

Dr.Gordon Giesbrecht

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Gordon Giesbrecht, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Manitoba

Locations

211 Max Bell Centre, University of Manitoba

Winnipeg, Manitoba, Canada

Countries

Canada

References

Hurrie DMG, Talebian Nia M, Power K, Stecina K, Gardiner P, Lockyer E, Giesbrecht GG. Spinal and corticospinal excitability in response to reductions in skin and core temperatures via whole-body cooling. Appl Physiol Nutr Metab. 2022 Feb;47(2):195-205. doi: 10.1139/apnm-2021-0370. Epub 2021 Sep 28.

Reference Type: DERIVED

PMID: 34582724 (View on PubMed)

Other Identifiers

E2018:047 (HS21827)

Identifier Type: -

Identifier Source: org_study_id