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Inhibitory Control: Effects of Modulation

NCT ID: NCT04247334

Last Updated: 2023-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

108 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-14

Study Completion Date

2024-04-01

Brief Summary

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Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.

Detailed Description

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Conditions

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Young Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Cautious Participants

Participants who have low scores on a self-report of inhibitory control abilities (BRIEF-Inhibit).

Group Type NO_INTERVENTION

No interventions assigned to this group

Impulsive Participants- Active Stimulation

Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to active stimulation.

Group Type EXPERIMENTAL

Transcranial direct current stimulation

Intervention Type DEVICE

20 minutes of 2 milliamp transcranial direct current stimulation

Impulsive Participants- Sham Stimulation

Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to sham stimulation.

Group Type SHAM_COMPARATOR

Transcranial direct current stimulation

Intervention Type DEVICE

20 minutes of 2 milliamp transcranial direct current stimulation

Interventions

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Transcranial direct current stimulation

20 minutes of 2 milliamp transcranial direct current stimulation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Low (\<1sd below the mean on the BRIEF-Inhibit) or high (\>1sd above the mean on BRIEF-Inhibit scale)
2. English fluency to ensure comprehension of study measures and instructions.

Exclusion Criteria

1. Presence of medical conditions contraindicated for tDCS, including history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or women of childbearing age not using effective contraception, or any other serious medical conditions or health problems that would interfere with participation (e.g., skin condition)
2. Inability to undergo MRI
3. Current substance abuse disorder
4. Currently prescribed psychiatric medications.
5. Active mania or psychosis
Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Butler Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Butler Hospital

Providence, Rhode Island, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Nicole McLaughlin, PhD

Role: CONTACT

Phone: 4014556608

Email: [email protected]

Other Identifiers

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1352651-9

Identifier Type: -

Identifier Source: org_study_id