Prophylactic Treatment of Skin Rash Associated With EGFR Inhibitor Therapy

NCT ID: NCT04239846

Last Updated: 2022-04-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 74 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-10-02
• Study Completion Date: 2021-05-26

Brief Summary

Epidermal growth factor receptor inhibitor (EGFRI) therapy for cancer is associated with potentially severe face and trunk skin acneiform rash. Severe or persistent side effects may lead to decreased dose, interruption or discontinuation of EGFRI treatment. Inflammation is believed to play an important role in EGFRI-induced skin toxicity as a number of proinflammatory cytokines induced by EGFRI are released from epidermal cells, resulting in activation and recruitment of immune cells such as neutrophils and lymphocytes, and subsequent development of skin reaction associated with keratinocyte apoptosis. AC-701 has been reported its antibiotic and anti-inflammatory activities in literature, and further demonstrated in vitro effect to prevent the secretion of inflammatory cytokines associated with EGFR inhibition. This study is to evaluate the prophylactic efficacy of topical AC-701 in subjects with skin rash associated with EGFRI therapy.

Conditions

EGFR Inhibitor-Induced Skin Rash

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

AC-701

AC-701 Topical Gel 0.3%

Group Type: EXPERIMENTAL

AC-701 Topical Gel 0.3%

Intervention Type: DRUG

AC-701 Topical Gel 0.3%, BID

Placebo

Placebo Gel

Group Type: PLACEBO_COMPARATOR

Placebo Gel

Intervention Type: OTHER

Placebo Gel, BID

Interventions

AC-701 Topical Gel 0.3%

AC-701 Topical Gel 0.3%, BID

Intervention Type: DRUG

Placebo Gel

Placebo Gel, BID

Intervention Type: OTHER

Other Intervention Names

AC-701; Placebo control

Eligibility Criteria

Inclusion Criteria

1. Is between 20 and 80 years of age, inclusive.

2. Patients who are within ±3 days of initiating EGFR inhibitor therapy using afatinib or erlotinib, and have no prior history of using afatinib or erlotinib within 6 months.

3. Has a life expectancy of at least three months.

Exclusion Criteria

1. Has any active dermatological conditions of the face that may interfere with the diagnosis, assessment, or treatment of face skin rash associated with targeted cancer therapy.

2. Has been treated with steroids (systemic or topical on face) to the face within 7 days prior to Day 1.

3. Patients who have been treated with oral antibiotics that known to exert anti-inflammatory effect (such as doxycycline or minocycline) within 7 days prior to Day 1.

4. Is currently treated with target therapy other than afatinib or erlotinib.

5. Receive prior treatment with any investigational product within 28 days prior to Day 1.

6. Has hypersensitivity or allergy to the study medication.

7. Has any other significant diseases, conditions, or laboratory values which, in the opinion of the investigator, might make participation not in the subject's best interest or confound the interpretation of study results.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

TWi Biotechnology, Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Emily Lin

Role: STUDY_DIRECTOR

TWi Biotechnology, Inc.

Locations

Taipei Veterans General Hospital

Taipei, , Taiwan

Chang Gung Memorial Hospital

Taoyuan District, , Taiwan

Countries

Taiwan

Other Identifiers

AC-701-ONC-002

Identifier Type: -

Identifier Source: org_study_id