Characterizing the Cross-sectional Approach to Investigate the Prevalence of Tissue BRCA1/2 Mutations in Newly Diagnosed Advanced Ovarian Cancer Patients

NCT ID: NCT04222465

Last Updated: 2021-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

207 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-19

Study Completion Date

2020-11-13

Brief Summary

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This is a multi-center, observational study in Japan. Patients with newly diagnosed FIGO stage III - IV advanced OC will be enrolled sequentially.

In this study, data of 200 subjects will be collected at approximately 20 sites in Japan. To reduce regional bias of study sites, the number of enrolled patients per site will be capped

Detailed Description

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Study design:This is a multi-center, observational study in Japan. Patients with newly diagnosed FIGO stage III - IV advanced OC will be enrolled sequentially.

In this study, data of 200 subjects will be collected at approximately 20 sites in Japan. To reduce regional bias of study sites, the number of enrolled patients per site will be capped.

Study population:Patients with FIGO stage III - IV epithelial ovarian cancer Drug exposure:Not applicable Planned study sites and sample size:The objective number of patients will be 200 from approximately 20 hospitals.

Conditions

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Ovarian Neoplasms

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Aged 20 years or older of Japanese women at the time of consent (the age of death, in case of dead patient)
* Newly diagnosed as advanced OC (FIGO stage III - IV) with epithelial ovarian cancer, primary peritoneal cancer or fallopian-tube cancer \[or a combination of these cancers\] after January 1, 2019
* Patients who have archived formalin-fixed paraffin-embedded (FFPE) samples of primary or peritoneal metastatic tumor collected after January 1, 2019
* Patients who have undergone or are scheduled to undergo BRACAnalysis
* Patients who give their written informed consent to participate in this study (However, the cases of death should be handled in accordance with the instructions of the Ethical Review Board of each site.)

Exclusion Criteria

* Patients who are not recommended enrolling this study decided by physician
Minimum Eligible Age

20 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Research Site

Matsuyama, Ehime, Japan

Site Status

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Tōon, Ehime, Japan

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Yoshida, Fukui, Japan

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Kitakyushu, Fukuoka, Japan

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Sapporo, Hokkaido, Japan

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Amagasaki, Hyōgo, Japan

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Kobe, Hyōgo, Japan

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Tsukuba, Ibaraki, Japan

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Sendai, Miyagi, Japan

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Kashihara, Nara, Japan

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Izumo, Shimane, Japan

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Bunkyo, Tokyo, Japan

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Minato, Tokyo, Japan

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Musashino, Tokyo, Japan

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Shinjuku, Tokyo, Japan

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Fukushima, , Japan

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Gifu, , Japan

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Kumamoto, , Japan

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Niigata, , Japan

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Yamagata, , Japan

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Countries

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Japan

Other Identifiers

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D0817R00018

Identifier Type: -

Identifier Source: org_study_id