Ostomy in Continuity or Conventional Ileostomy: a Retrospective Multicentric Analysis

NCT ID: NCT04213976

Last Updated: 2019-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-12-31

Brief Summary

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Surgical procedures for complex intestinal neonatal and paediatric diseases may require the use of an ostomy, in order to discharge the upper intestine. The traditional loop ileostomy has recently be challenged by ileostomies in continuity, either the Santulli or the Bishop-Koop one, that both decompresses the proximal dilated bowel and allow intestine fluid to pass through the underlying ileal anastomosis. Nevertheless, to date, no evaluation of their indications, complications and potential benefits has been made.

The aim of this study is to retrospectively compare the outcomes of loop ileostomies and ileostomies in continuity in a paediatric population.

It is thus expected to better define the specific indications for these different types of ileostomies in the paediatric and neonatal population.

Detailed Description

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The methodology used will be a retrospective non interventional study of the cohorts of paediatric patients having had one or more ileostomies performed in one of the surgical centers participating in this study, between 2007, january the 1st and 2019, august the 31th.

The main outcome will be the duration (days) between full refunctionalization of the bowel in the groups of conventional ileostomy or ostomy in continuity, as assessed by the end of parenteral nutrition or the closure of the stoma.

Secondary outcomes will include (1) the number and type of complications directly related to the stoma and/or to intestinal complications; (2) the comparison of the results obtained by Santulli and Bishop-Koop ileostomies; (3) a sub-group analysis of the outcomes in the different underlying pathologies.

Conditions

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Intestinal Obstruction Gastroschisis Enterocolitis, Necrotizing Hirschsprung Disease

Keywords

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ileostomy enteral nutrition complications of stoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Ileostomy in continuity

Paediatric patients having had an ileostomy in continuity as part of the treatment for a complex intestinal obstruction, as described by Santulli or by Bishop-Koop.

Ileostomy

Intervention Type PROCEDURE

Use of an ileostomy to decompress the proximal bowel, perfored either as a conventional loop ileostomy or as described by Santulli et al. or by Bishop and Koop.

Conventional ileostomy

Paediatric patients having had a loop ileostomy as part of the treatment for a complex intestinal obstruction.

Ileostomy

Intervention Type PROCEDURE

Use of an ileostomy to decompress the proximal bowel, perfored either as a conventional loop ileostomy or as described by Santulli et al. or by Bishop and Koop.

Interventions

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Ileostomy

Use of an ileostomy to decompress the proximal bowel, perfored either as a conventional loop ileostomy or as described by Santulli et al. or by Bishop and Koop.

Intervention Type PROCEDURE

Other Intervention Names

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Loop ileostomy Santulli ileostomy Bishop-Koop ileostomy

Eligibility Criteria

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Inclusion Criteria

* all patient aged 16 or less having had one or more ileostomy created as part of its care for an intestinal obstruction, between 2007/01/01 and 2019/08/31. If a patient requires more than one ileostomy, each new stoma will be analysed as a new entry in the study.
* patients having been operated in one of the paediatric surgical department participating in this study.

Exclusion Criteria

* refusal or absence on consent of the patient and/or their legal representative to participate to the study.
* patient who had an ileostomy created in another center than the ones participating in the present study.
Minimum Eligible Age

1 Minute

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Angers

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Françoise Schmitt, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Angers

Locations

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University Hospital of Brest

Brest, , France

Site Status

University Hospital of Nantes

Nantes, , France

Site Status

Necker Enfants Malades Hospital

Paris, , France

Site Status

University Hospital of Rennes

Rennes, , France

Site Status

University Hospital of Tours

Tours, , France

Site Status

Countries

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France

Central Contacts

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Françoise Schmitt, MD, PhD

Role: CONTACT

Phone: +33241354290

Email: [email protected]

Facility Contacts

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Philine De Vries, MD, PhD

Role: primary

Sébastien Faraj, MD

Role: primary

Sabine Sarnacki, MD, PhD

Role: primary

Alexis Arnaud, MD, PhD

Role: primary

Itissam Kassite, MD

Role: primary

References

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BISHOP HC, KOOP CE. Management of meconium ileus; resection, Roux-en-Y anastomosis and ileostomy irrigation with pancreatic enzymes. Ann Surg. 1957 Mar;145(3):410-4. doi: 10.1097/00000658-195703000-00017. No abstract available.

Reference Type RESULT
PMID: 13403593 (View on PubMed)

SANTULLI TV, BLANC WA. Congenital atresia of the intestine: pathogenesis and treatment. Ann Surg. 1961 Dec;154(6):939-48. No abstract available.

Reference Type RESULT
PMID: 14497096 (View on PubMed)

Sehgal S, Sandler AD, Alfred Chahine A, Mohan P, Torres C. Ostomy in continuity: A novel approach for the management of children with complex short bowel syndrome. J Pediatr Surg. 2018 Oct;53(10):1989-1995. doi: 10.1016/j.jpedsurg.2018.02.059. Epub 2018 Mar 4.

Reference Type RESULT
PMID: 29602547 (View on PubMed)

Other Identifiers

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2019/10

Identifier Type: -

Identifier Source: org_study_id