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Evaluating Radiomorphometric Indices and Fractal Dimension of the Pediatric Oncology Patients on Panoramic Images

NCT ID: NCT04213482

Last Updated: 2019-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-15

Study Completion Date

2019-12-20

Brief Summary

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This study evaluated pediatric oncology patients in terms of quality of bone and determine any relation between bone quality and radiotherapy/chemotherapy. The alternative hypothesis is that the bone quality of the oncology patients who received radiotherapy/chemotherapy is lower than the control group.

Detailed Description

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Cancer is the abnormal and uncontrolled proliferation of certain tissues in the body for a reason that cannot be determined yet. Childhood cancers occur between 0-17 years of age, and follow-up and treatment of these patients are performed in pediatric oncology services. Diagnosis in childhood cancers can be made by clinical examination as well as blood tests and examination of tissue samples. There are also some imaging methods used for diagnosis; ultrasonography, computed tomography, magnetic resonance imaging, positron emission tomography / computed tomography (PET / CT).

Treatment methods in childhood cancers are as follows; surgery, chemotherapy, radiotherapy and stem cell transplantation. Once diagnosed, oncologists and surgeons may choose one of these treatment options by mutual consultation or decide on a treatment method. Fractal analysis is a numerical as fractal dimension. Trabeculae are thin columns with numerous large spaces that give a honeycomb or spongy appearance of cancellous bone, which is also called trabecular bone or spongy bone. Previously, fractal analysis has been reported as a useful method to detect various diseases that affect the trabecular bone structure. Particularly in the field of dentistry, studies have shown that fractal analysis by the box-counting method can successfully evaluate trabecular changes in the mandible of patients with osteoporosis and periodontal diseases and in lactating women.

Conditions

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Oncology Bone Loss

Keywords

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pediatric oncology fractal analysis panoramic mandibular indices radiotherapy chemotherapy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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oncology patients

For this study, panoramic images were taken from pediatric patients who received radiotherapy and/or chemotherapy because of any oncologic disease.

Panoramic Radiography

Intervention Type RADIATION

Diagnostic Panoramic Dental Radiographs were taken.

healthy

panoramic images of patients(pediatric) who have no systemic disease were collected from the archive of dental radiology clinic of the university hospital.

Panoramic Radiography

Intervention Type RADIATION

Diagnostic Panoramic Dental Radiographs were taken.

Interventions

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Panoramic Radiography

Diagnostic Panoramic Dental Radiographs were taken.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* to have been treated for any oncological diseases in childhood
* oncological treatment completed at least one year ago

Exclusion Criteria

* ongoing oncological treatment
* patients who unwilling to participate to study
Minimum Eligible Age

6 Years

Maximum Eligible Age

23 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nuh Naci Yazgan University

OTHER

Sponsor Role lead

Responsible Party

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Hatice Cansu Kış

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Nuh Naci Yazgan University

Kayseri, Kocasinan, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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2018/209

Identifier Type: -

Identifier Source: org_study_id