The Status of Helicobacter Pylori Infection Among Children Visiting Assiut Children Hospital
NCT ID: NCT04212585
Last Updated: 2020-11-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2021-01-01
2022-01-01
Brief Summary
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Detailed Description
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Currently, little data exist regarding the epidemiology of H. pylori associated infection in our region., especially in children. Therefore, this study aims to determine the prevalence of H. pylori among children.
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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children with upper gastrointestinal symptoms
Serology test
Serology for Helicobacter pylori (immunoglobulin G for all sites, immunoglobulin M optional, immunoglobulin A optional) will be collected from all participants. 90 samples (immunoglobulin G, immunoglobulin M and immunoglobulin A) at least needed from each site.
Stool antigen for Helicobacter pylori
children without upper gastrointestinal symptoms
Serology test
Serology for Helicobacter pylori (immunoglobulin G for all sites, immunoglobulin M optional, immunoglobulin A optional) will be collected from all participants. 90 samples (immunoglobulin G, immunoglobulin M and immunoglobulin A) at least needed from each site.
Stool antigen for Helicobacter pylori
Interventions
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Serology test
Serology for Helicobacter pylori (immunoglobulin G for all sites, immunoglobulin M optional, immunoglobulin A optional) will be collected from all participants. 90 samples (immunoglobulin G, immunoglobulin M and immunoglobulin A) at least needed from each site.
Stool antigen for Helicobacter pylori
Eligibility Criteria
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Inclusion Criteria
Participants will be recruited from the following sources:
1. Children with non-GI symptoms (ophthalmology, ear, nose, and throat , chest departments .. etc)
2. Children with GI symptoms undergoing upper GI endoscopy (from GI endoscopy units).
Simple questionnaire will be used to collect demographic data, socioeconomic status, dietary habits, and gastrointestinal complaints from parents of all participants before testing for Helicobacter pylori.
Exclusion Criteria
2. For any diagnostic test other than serology (stool antigen, rapid Urease test, urea breath test, histopathology) the following patients will be excluded:
* Children received any antibiotics in the last month
* Children received bismuth compounds in the last month.
* Children received proton pump inhibitors in the last 2 weeks.
* Children presenting with upper gastrointestinal bleeding.
18 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Ebtihal Ramadan Hashem
Principal Investigator
Principal Investigators
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Magda S Hasan, M.D.
Role: STUDY_DIRECTOR
Assiut University
Central Contacts
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References
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Blecker U. Helicobacter pylori-associated gastroduodenal disease in childhood. South Med J. 1997 Jun;90(6):570-6; quiz 577.
Tonkic A, Tonkic M, Lehours P, Megraud F. Epidemiology and diagnosis of Helicobacter pylori infection. Helicobacter. 2012 Sep;17 Suppl 1:1-8. doi: 10.1111/j.1523-5378.2012.00975.x.
Mohammad MA, Hussein L, Coward A, Jackson SJ. Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth. Public Health Nutr. 2008 Mar;11(3):230-6. doi: 10.1017/S1368980007000481. Epub 2007 Aug 1.
Takahashi M, Kimura H, Watanabe K. Helicobacter pylori infection in patients with idiopathic short stature. Pediatr Int. 2002 Jun;44(3):277-80. doi: 10.1046/j.1442-200x.2002.01557.x.
Malaty HM, Logan ND, Graham DY, Ramchatesingh JE, Reddy SG. Helicobacter pylori infection in asymptomatic children: comparison of diagnostic tests. Helicobacter. 2000 Sep;5(3):155-9. doi: 10.1046/j.1523-5378.2000.00024.x.
Roma E, Miele E. Helicobacter pylori Infection in Pediatrics. Helicobacter. 2015 Sep;20 Suppl 1:47-53. doi: 10.1111/hel.12257.
Sustmann A, Okuda M, Koletzko S. Helicobacter pylori in children. Helicobacter. 2016 Sep;21 Suppl 1:49-54. doi: 10.1111/hel.12341.
Plummer M, Franceschi S, Vignat J, Forman D, de Martel C. Global burden of gastric cancer attributable to Helicobacter pylori. Int J Cancer. 2015 Jan 15;136(2):487-90. doi: 10.1002/ijc.28999. Epub 2014 Jun 11.
Other Identifiers
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H.Pylori status
Identifier Type: -
Identifier Source: org_study_id