Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2019-11-25
2020-12-31
Brief Summary
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This is a one armed study where in 30 breast cancer survivors will be recruited to a 4 month exercise intervention. Increase in muscle mass and strength will be correlated with immune cell frequency and function.
Detailed Description
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To test this hypothesis, the investigators will recruit 30 breast cancer survivors to an exercise program designed to increase their muscle mass and strength. The program will be optimized to each participant's level of fitness and strength and will be designed by experts in the field. Personal trainers will teach the participants how to exercise and use muscle resistance training equipment using the correct technique and will monitor progress to avoid injuries and to maximize training benefits.
The investigators will collect blood (to study immune cell subsets) and measure muscle strength and body composition (to measure muscle mass) for participants before and after the study.
The duration of the exercise training protocol is 4 months and participants will be asked to exercise 4 days a week; 2 days at the gym and 2 days at home.
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Exercise
Four months of muscle resistance training (exercise) designed to increase muscle mass and strength. The exercise protocol includes four different lifts with weights including, squats, bench press, dead lift and overhead press. The weights for each lift will be optimized for each participant and increased as the participant adapts to the exercise routine.
Exercise Intervention
Participants will exercise under the supervision of expert personal trainers and follow an optimized exercise program tailored to the strength and fitness level of each participant. Participants will exercise for 16 weeks; 2 days a week at the gym for an hour and 2 days of the week at home for 45 minutes.
Interventions
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Exercise Intervention
Participants will exercise under the supervision of expert personal trainers and follow an optimized exercise program tailored to the strength and fitness level of each participant. Participants will exercise for 16 weeks; 2 days a week at the gym for an hour and 2 days of the week at home for 45 minutes.
Eligibility Criteria
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Inclusion Criteria
* Post menopausal
* Stage I - III breast cancer
* Breast cancer the only cancer
* Can exercise for 16 weeks; 2 days a week at the gym and 2 days of the week at home
* Live in the San Diego area
Exclusion Criteria
* Are on chemotherapy or radiation therapy or have been in the past month
* Will be on chemotherapy or radiation therapy in the next 6 months
* Have a condition that will prevent them from exercising in the gym
FEMALE
No
Sponsors
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California Breast Cancer Research Program
OTHER
Arizona State University
OTHER
Tri-City Wellness & Fitness Center
UNKNOWN
We Support U
UNKNOWN
San Diego Biomedical Research Institute
OTHER
Responsible Party
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Joanna Davies
President and CEO, Professor
Principal Investigators
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Joanna D Davies, PhD
Role: PRINCIPAL_INVESTIGATOR
San Diego Biomedical Research Institute
Locations
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Aditi Narsale
San Diego, California, United States
Countries
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References
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Narsale A, Moya R, Ma J, Anderson LJ, Wu D, Garcia JM, Davies JD. Cancer-driven changes link T cell frequency to muscle strength in people with cancer: a pilot study. J Cachexia Sarcopenia Muscle. 2019 Aug;10(4):827-843. doi: 10.1002/jcsm.12424. Epub 2019 Apr 12.
Related Links
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Information about the study on the official San Diego Biomedical Research Institute website
Visit us at the link above for more information about the study
Other Identifiers
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25IB-0023
Identifier Type: -
Identifier Source: org_study_id