Hemophilia and Bone Metabolism: Study of Monocytic Populations and Inflammatory Proteins

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

73 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-11-29

Study Completion Date

2020-12-31

Brief Summary

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The investigators propose, as part of the study, to carry out for each patient:

* An analysis of monocytic populations by flow cytometry (CD14, CD16, CD45, CD68, CD115, CCR2, CX3CR1, CD163 and CD206).
* A population assessment of Myeloid-Derived Suppressor Cells (MDSC).
* Assays of cytokines and chemokines involved in inflammation by multiplex analyzes: Il-1 (α and β), Il-4, Il-6, Il-10, Il-13, TNF- α, TGF- β, CRP , leptin, IFN- β.
* Specialized dosages of proteins involved in bone metabolism. RANKL, osteoprotegerin, M-CSF, TRAPCP5.

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Detailed Description

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Conditions

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Hemophilia Osteopenia Arthropathy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Observational study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Major patients followed at the hemophilia treatment reference center,
* Presenting the diagnosis of severe, moderate or minor Hemophilia A / B,
* Having a social security system,
* Obtaining the oral non-objection collection from the patient after information.

Exclusion Criteria

* Minor patients, under guardianship or curatorship.
* Causes of secondary osteoporosis:

* Systemic corticosteroid therapy in progress (≥ 3 consecutive months, at a dosage ≥ 7.5 mg / d of prednisone equivalent).
* other treatment or condition responsible for osteoporosis: prolonged or medicated hypogonadism, untreated active hyperthyroidism, hypercorticism, primary hyperparathyroidism.
* Treatment with biphosphonates, biotherapies or hormone therapy in the treatment of prostate cancer.

Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No