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Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma

NCT ID: NCT04205708

Last Updated: 2023-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

183 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-14

Study Completion Date

2022-06-10

Brief Summary

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Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure. The central hypothesis of this study is that silicosis cases may currently be going undetected. The long-term goal of this research is to determine the current prevalence and forecast the future prevalence of silicosis and other pneumoconiosis among working populations in Oklahoma and to assist the public health and the healthcare system in planning for a potential resurgence of silicosis.

Detailed Description

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Conditions

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Silicosis Pneumoconiosis; Silica

Keywords

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silica public health early prevention silicosis screening Oklahoma lung disease pulmonology Pneumoconiosis lung dust exposure occupational health community health

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Interventions

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Tuberculosis test

Tuberculosis (TB) test: A blood sample is collected for lab testing to determine if you have tuberculosis (QuantiFeron test). Alternatively, the test is done by injecting a small amount of fluid (called tuberculin) into the skin on the lower part of the arm. A person given the tuberculin skin test must return within 48 to 72 hours to have a trained health care worker look for a reaction on the arm.

Intervention Type DIAGNOSTIC_TEST

Chest X-ray

Chest X ray: non-invasive medical test that helps physicians diagnose and treat medical conditions of the lungs and chest. The Chest X-ray will be done to check for abnormalities on the lungs. The test is non-invasive.

Intervention Type DIAGNOSTIC_TEST

Pulmonary Function Test

A pulmonary function test (PFT, spirometry) is a breathing test that measures how much air your lungs can hold as well as how hard and fast you can blow air out of your lungs. The test is not invasive and involves blowing into a machine.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Mantoux skin test QuantiFeron test Spirometry Forced Spirometry

Eligibility Criteria

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Inclusion Criteria

* Male 30 years or older
* Past or present employment in dusty environment, exposed to dust at work
* Ability to consent and answer the questionnaire

Exclusion Criteria

* Female
* Never exposed to dusty environment or never exposed to dust at work
* Inability to consent and answer the questionnaire
* Age 29 years or younger
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Oklahoma

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jad Kebbe, MD

Role: PRINCIPAL_INVESTIGATOR

University of Oklahoma

Locations

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University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status

Countries

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United States

Other Identifiers

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10140

Identifier Type: -

Identifier Source: org_study_id