Phase-II Trial of Induction Chemotherapy and Chemoradiotherapy Plus/Minus Durvalumab and Consolidation Immunotherapy in Patients With Resectable Stage III NSCLC.

NCT ID: NCT04202809

Last Updated: 2023-05-10

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 90 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-01-13
• Study Completion Date: 2025-04-30

Brief Summary

To compare a complex induction multimodality protocol (ESPATUE) + concurrent immunotherapy with PD-L1 antibody Durvalumab given every three weeks to the same induction multimodality protocol without Durvalumab immunotherapy induction followed by definitive local treatment (surgery for those considered resectable or chemoradiation boost for those not considered to be R0-resectable) followed by consolidation Durvalumab treatment in both arms.

Conditions

NSCLC, Stage III

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Chemo- and Radiochemotherapy + Durvalumab

Group Type: EXPERIMENTAL

Durvalumab

Intervention Type: DRUG

Durvalumab is given earlier as registered, during chemotherapy and radiotherapy in treatment Arm A

Chemo- and Radiochemotherapy

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Durvalumab

Durvalumab is given earlier as registered, during chemotherapy and radiotherapy in treatment Arm A

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Body weight >30 kg

2. Age ≥ 18 years and < 75 years

3. Male or female patients. Female (as well as male) patients have to take care of effective measures of anticonception

4. Histologically proven non-small cell lung cancer

5. Selected patients with non-small cell lung cancer stages IIIA and IIIB:

6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

7. Resectable disease at the time of inclusion

8. Fulfillment of adequate criteria for functional and medical resectability as described in the European Respiratory Society (ERS)/European Society of Thoracic Surgeons (ESTS) guidelines [Brunelli et al 2009] and acceptable general clinical condition for multimodality treatment (interdisciplinary committee)

9. Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol. Written informed consent and any locally required authorization (e.g, European Union [EU] Data Privacy Directive in the EU) obtained from the patient/legal representative prior to performing any protocol-related procedures, including screening evaluations.

10. Must have a life expectancy of > 12 weeks

11. Adequate normal organ and marrow function

12. Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients. Women will be considered post-menopausal if they have been amenorrheic for 12 months without an alternative medical cause. The following age-specific requirements apply:

13. Patient is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.

14. Stable cardiac function (no Myocardial infarction (MI) within 6 months, no heart failure according to New York Heart Association (NYHA) III-IV).

Exclusion Criteria

1. resectable IIB or selected IIIA (T3N0; T3N1)

2. unresectable disease pre-treatment

3. mixed histology with areas of small cell carcinoma (neuroendocrine markers)

4. clinically symptomatic vena cava superior syndrome

5. diffuse mediastinal involvement

6. patients with T3N3 and T4N3 tumors (IIIC according to International Association for the Study of Lung Cancer (IASLC)/Union Internationale Contre le Cancer (UICC) 8)

7. invasion of the thoracic aorta (T4 - aorta)

8. invasion of the heart (except left atrium - T4 - heart)

9. invasion of the esophagus (T4 - esophagus)

10. invasion of spine (T4 - spine)

11. (full blown) Pancoast-syndrome in tumors of the superior sulcus (T3-4 Nx)

12. malignant (positive) pericardial effusion (M1a - pericardial effusion)

13. malignant (positive) pleural effusion (M1a - pleural effusion)

14. involvement of the contralateral hilar nodes (if any data available)

15. endobronchial tumor extension to the contralateral main stem bronchus

16. ipsi- or contralateral supraclavicular nodes (N3 - supraclavicular nodes)

17. lung or heart function not allowing at the time of inclusion the intended surgical procedure

18. previous administration of chemotherapy and/or radiotherapy

19. previous immunotherapy

20. insufficient patients compliance (e.g. symptomatic psychiatric disorder)

21. loss of weight > 10 % in the last six months

22. missing written informed consent or definitive refusal for participation

23. Participation in another clinical study with an investigational product during the last 12 months

24. Concurrent enrolment in another clinical study, unless it is an observational (non-interventional) clinical study or during the follow-up period of an interventional study

25. Must not have required the use of additional immunosuppression other than corticosteroids for the management of an Adverse Event (AE), not have experienced recurrence of an AE if re-challenged, and not currently require maintenance doses of > 10 mg prednisone or equivalent per day

26. History of idiopathic pulmonary fibrosis, pneumonitis (including drug induced), organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis on screening chest CT scan

27. Any concurrent chemotherapy, Intraperitoneal (IP), biologic, or hormonal therapy for cancer treatment. Concurrent use of hormonal therapy for non-cancer-related conditions (e.g., hormone replacement therapy) is acceptable.

28. Major surgical procedure (as defined by the Investigator) within 28 days prior to the first dose of IP. Note: Local surgery of isolated lesions for palliative intent is acceptable.

29. History of allogenic organ transplantation.

30. History of a stem cell transplantation

31. Active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis [with the exception of diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid arthritis, hypophysitis, uveitis, etc.]).

32. Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent

33. History of another primary malignancy

34. History of active primary immunodeficiency

35. Active infection including tuberculosis (TB) (clinical evaluation that includes clinical history, physical examination and radiographic findings, and TB testing in line with local practice), hepatitis B (known positive Hepatitis B Virus (HBV) surface antigen (HBsAg) result), hepatitis C, or human immunodeficiency virus (positive HIV ½ antibodies). Patients with a past or resolved HBV infection (defined as the presence of hepatitis B core antibody (anti-HBc) and absence of HBsAg) are eligible. Patients positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RNA.

36. Current or prior use of immunosuppressive medication within 14 days before the first dose of Durvalumab.

37. Current or prior use of immunostimulatory agents within 14 days before the first dose of Durvalumab.

38. Receipt of live attenuated vaccine within 90 days prior to the first dose of IP. Note: Patients, if enrolled, should not receive live vaccine whilst receiving IP and up to 90 days after the last dose of IP.

39. Female patients who are pregnant or breastfeeding or male or female patients of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose of Durvalumab monotherapy.

40. Known allergy or hypersensitivity to Durvalumab or any excipient

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 74 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Essen

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Wilfried Eberhardt, PD MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Essen

Locations

Klinikum rechts der Isar - Technische Universität München

Munich, Bavaria, Germany

Site Status: RECRUITING

Universitätsklinikum Essen

Essen, , Germany

Site Status: RECRUITING

Universitätsklinikum Freiburg

Freiburg im Breisgau, , Germany

Site Status: RECRUITING

Lungenklinik Hemer Deutscher Gemeinschafts-Diakonieverband GmbH

Hemer, , Germany

Site Status: RECRUITING

Pius-Hospital Oldenburg

Oldenburg, , Germany

Site Status: RECRUITING

Universitätsklinikum Regensburg

Regensburg, , Germany

Site Status: RECRUITING

Robert-Bosch-Krankenhaus

Stuttgart, , Germany

Site Status: RECRUITING

Countries

Germany

Central Contacts

Andrea Moell, PhD

Role: CONTACT

andrea.moell@uk-essen.de

0049 201 72377412 ext. 77412

Facility Contacts

Stephanie Combs, Prof. Dr.

Role: primary

Monika Serke, MD

Role: primary

Christian Schulz, Prof. Dr.

Role: primary

Other Identifiers

ESPADURVA

Identifier Type: -

Identifier Source: org_study_id