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Effect of RIC on 2,3-BPG in Erythrocyte (RIC-BPG)

NCT ID: NCT04192578

Last Updated: 2020-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-15

Study Completion Date

2021-03-15

Brief Summary

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Under hypoxia or high-altitude hypoxia ,it has been found that 2,3-bisphosphoglycerate(2,3-BPG) in erythrocyte increased and facilitated oxygen release to tissues.Remote Ischemic Conditioning(RIC) can also cause hypoxic conditions in local limbs.Thus,we hypothesize that whether RIC could also increase 2,3-BPG in erythrocyte.

Detailed Description

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RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently and has been proved to be effective in ischemic stroke and myocardial infarction(MI).The possible mechanisms of RIC protection is complicated.RIC leads to local ischemia and hypoxia and has been demonstrated to play a role in vital organs through hypoxia inducible factors(HIF) against stroke and MI.Besides HIF, hypoxia or high-altitude hypoxia could also change glycolytic process in erythrocyte through adenosine or sphingosine-1-phosphate(S1P).Accompanying with alternating glucolysis, 2,3-diphosphoglycerate(2,3-BPG) in erythrocyte increases and it also facilitating oxygen release to tissues.Thus,we hypothesize that whether RIC could also increase 2,3-BPG in erythrocyte.There are 8 arms in this trial: All arms are RIC treatment. The level of 2,3-BPG in erythrocyte will be assessed by ELISA before and after the treatment.

Conditions

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2,3-Bisphosphoglycerate

Keywords

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Remote ischemic conditioning 2,3-Bisphosphoglycerate Erythrocyte Oxygen healthy subjects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Study Groups

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Unilateral upper limb 60mmHg RIC

RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on unilateral upper limb and inflated to 60 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Group Type EXPERIMENTAL

remote ischemic conditioning

Intervention Type DEVICE

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Bilateral upper limb 60mmHg RIC

RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral upper limb and inflated to 60 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Group Type EXPERIMENTAL

remote ischemic conditioning

Intervention Type DEVICE

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Unilateral upper limb 200mmHg RIC

RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on unilateral upper limb and inflated to 200 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Group Type EXPERIMENTAL

remote ischemic conditioning

Intervention Type DEVICE

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Bilateral upper limb 200mmHg RIC

RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral upper limb and inflated to 200 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Group Type EXPERIMENTAL

remote ischemic conditioning

Intervention Type DEVICE

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Unilateral lower limb 60mmHg RIC

RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on unilateral lower limb and inflated to 60 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Group Type EXPERIMENTAL

remote ischemic conditioning

Intervention Type DEVICE

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Bilateral lower limb 60mmHg RIC

RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral lower limb and inflated to 60 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Group Type EXPERIMENTAL

remote ischemic conditioning

Intervention Type DEVICE

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Unilateral lower limb 200mmHg RIC

RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on unilateral lower limb and inflated to 200 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Group Type EXPERIMENTAL

remote ischemic conditioning

Intervention Type DEVICE

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Bilateral lower limb 200mmHg RIC

RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral lower limb and inflated to 200 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Group Type EXPERIMENTAL

remote ischemic conditioning

Intervention Type DEVICE

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Interventions

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remote ischemic conditioning

RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Age:18-65 years old
2. Healthy adults

Exclusion Criteria

1. Individuals with various chronic diseases.
2. Individuals with various acute diseases.
3. Individuals who take any medicines
4. Individuals who have taken health supplements for more than 2 weeks.
5. individuals with BMI\<18.5 or BMI≥24
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Capital Medical University

OTHER

Sponsor Role lead

Responsible Party

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Ji Xunming,MD,PhD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xunming Ji, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Xuanwu Hospital, Beijing

Central Contacts

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Xunming Ji, MD, PhD

Role: CONTACT

Phone: 011-86-10-8319-8952

Email: [email protected]

Lin Wang

Role: CONTACT

Phone: 861013020025628

Email: [email protected]

Other Identifiers

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RIC-2,3-BPG

Identifier Type: -

Identifier Source: org_study_id