Impact of LPV During OFA on Postoperative Oxygen Saturation.
NCT ID: NCT04192305
Last Updated: 2019-12-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2019-12-01
2021-12-31
Brief Summary
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Detailed Description
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Alveolar collapse can be measured by oxygen saturation drop when no oxygen therapy is given, when full neuromuscular block (NMB) reversal and no opioid is given intra and postoperative.
LPV means:
tidal volume of 6 ml/kg, inspiratory-expiratory (I/E) ratio of 1/1, positive end expiratory pressure (PEEP) minimum 5 cmH20 and higher during laparoscopy in obese patients, Inspiratory oxygen concentration (FIO2) max 80% during induction and max 40 % during maintenance and extubation. Extubation in an awake, full NMB reversed patient getting no opioids while giving continuous positive airway pressure (CPAP) during withdrawal of the tube. Lung recruitment maneuver (LRM) when lung compliance decreases below 40 milliliter per centimeter water. (ml/cmH2O)
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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lung protective ventilation (LPV)
lung protective ventilation low tidal volume, minimum PEEP and higher PEEP and lung recruitment based on total lung compliance, low inspiratory oxygen concentration and CPAP during extubation without prior suctioning inside the endotracheal tube.
LPV
LPV means tidal volume of 6 ml/kg, inspiratory-expiratory (I/E) ratio of 1/1, positive end expiratory pressure (PEEP) minimum 5 cmH20 and higher during laparoscopy in obese patients, Inspiratory oxygen concentration (FIO2) 40 % during maintenance and extubation while also giving CPAP. Lung recruitment maneuver (LRM) when lung compliance decreases below 40 ml/cmH2O.
routine lung ventilation (LV)
ventilation and adapting PEEP, LRM and oxygen only when saturation drops.
routine LV
Give volume en frequency as required by end tidal carbon dioxide, PEEP and LRM only when saturation drops intra operative, no requirement to use low FIO2 and CPAP during extubation.
Interventions
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LPV
LPV means tidal volume of 6 ml/kg, inspiratory-expiratory (I/E) ratio of 1/1, positive end expiratory pressure (PEEP) minimum 5 cmH20 and higher during laparoscopy in obese patients, Inspiratory oxygen concentration (FIO2) 40 % during maintenance and extubation while also giving CPAP. Lung recruitment maneuver (LRM) when lung compliance decreases below 40 ml/cmH2O.
routine LV
Give volume en frequency as required by end tidal carbon dioxide, PEEP and LRM only when saturation drops intra operative, no requirement to use low FIO2 and CPAP during extubation.
Eligibility Criteria
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Inclusion Criteria
* morbid obesity ( BMI \> 35)
Exclusion Criteria
18 Years
ALL
No
Sponsors
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AZ Sint-Jan AV
OTHER
Responsible Party
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Jan Mulier
MD PhD
Principal Investigators
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Jan Paul Mulier
Role: PRINCIPAL_INVESTIGATOR
AZSint Jan AV
Locations
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Azsintjan
Bruges, , Belgium
Countries
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Central Contacts
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Mulier
Role: CONTACT
Other Identifiers
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OS impact LPV on SAT d OFA
Identifier Type: -
Identifier Source: org_study_id