Ventilation Heterogeneity Prior to Lung Resection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

115 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-06

Study Completion Date

2024-12-01

Brief Summary

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This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed tomography (V SPECT) and hyperpolarized 129Xe magnetic resonance imaging (MRI)), in the presence or absence of airway inflammation (assessed by sputum cell counts), in lung cancer patients prior to lung resection surgery.

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Detailed Description

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Conditions

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Lung Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Adults undergoing lung resection for lung cancer

Hyperpolarized 129Xe MRI

Intervention Type OTHER

Hyperpolarized 129Xe MRI to evaluate ventilation heterogeneity

Technegas V SPECT

Intervention Type OTHER

Technegas V SPECT to evaluate ventilation heterogeneity

Sputum Induction

Intervention Type OTHER

Sputum induction to evaluate luminal cellular inflammation

Interventions

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Hyperpolarized 129Xe MRI

Hyperpolarized 129Xe MRI to evaluate ventilation heterogeneity

Intervention Type OTHER

Technegas V SPECT

Technegas V SPECT to evaluate ventilation heterogeneity

Intervention Type OTHER

Sputum Induction

Sputum induction to evaluate luminal cellular inflammation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Undergoing lung resection for lung cancer at St. Joseph's Healthcare (Hamilton, Ontario) in accordance with British Thoracic Society guidelines.
* Males and females ≥ 18 years of age.
* Able and willing to provide written informed consent.
* Able and willing to comply with the study protocol.

Exclusion Criteria

* Previous lung resection surgery.
* Previous chest radiation.
* Patient has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples.
* In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia.
* Pregnancy.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No