Evolution of Fatigue in Patients With Inflammatory Bowel Disease

NCT ID: NCT04189692

Last Updated: 2019-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

202 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-07

Study Completion Date

2020-12-07

Brief Summary

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The aim of this study is to evaluate the evolution and possible factors associated with the persistence of fatigue in patients with quiescent IBD and fatigue included in two previous studies.

Detailed Description

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Fatigue is a common symptom in inflammatory bowel disease and persists despite clinical remission. Fatigue in patients with chronic diseases can be objectified by the FACIT-F scale.

Recent publications have tried to assess the prevalence and factors related to fatigue in patients with IBD.

In 2017 one study evaluated the prevalence and predictive factors of fatigue in out-patients with inflammatory bowel disease. Fatigue was associated with depression, low quality of life and female sex. No association was found with micronutrients or levels of interleukins.

As there are no effective treatments for fatigue in IBD, another study, recently published a study evaluating the role of electroacupuncture in 54 patients with quiescent IBD and fatigue, observing that both electroacupuncture and sham acupuncture improved fatigue compared to the control group.

The aim of this study is to evaluate the evolution and possible factors associated with the persistence of fatigue in patients with quiescent IBD and fatigue included in the two previous studies.

Patients with inflammatory bowel disease and fatigue (FACIT-F score \< 40) included in these two previous studies who agree to participate will fill in questionnaires to assess fatigue, anxiety, depression and quality of life in inflammatory bowel disease. Moreover, the relationship of other biological factors with IBD-related fatigue will be determined.

Conditions

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Fatigue Inflammatory Bowel Diseases Crohn Disease Ulcerative Colitis

Keywords

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Fatigue; Inflammatory Bowel Diseases Crohn Disease Ulcerative Colitis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients with Inflammatory Bowel Disease and fatigue

Patients with Inflammatory Bowel Disease and fatigue that participated in the two studies (1,2).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with inflammatory bowel disease and fatigue (defined as a FACIT-F score \<40 points) previously documented in our two previous studies.
* Written informed consent after receiving clear and objective information about the purpose and characteristics of the study.
* Ability to understand the questionnaires.

Exclusion Criteria

* Associated tumor disease.
* Pregnancy or breastfeeding.
* Anemia (hemoglobin \<12g/dl in women and 14g/dl in men)
* Any concomitant illness that may justify the presence of fatigue.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Corporacion Parc Tauli

OTHER

Sponsor Role lead

Responsible Party

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Diana Horta-Sangenis

gastroenterologist physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Diana Horta

Role: PRINCIPAL_INVESTIGATOR

Parc Tauli Hospital. Sabadell , Barcelona, Spain, 08208

Central Contacts

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Diana Horta

Role: CONTACT

Phone: 93 745 84 54

Email: [email protected]

References

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Villoria A, Garcia V, Dosal A, Moreno L, Montserrat A, Figuerola A, Horta D, Calvet X, Ramirez-Lazaro MJ. Fatigue in out-patients with inflammatory bowel disease: Prevalence and predictive factors. PLoS One. 2017 Jul 27;12(7):e0181435. doi: 10.1371/journal.pone.0181435. eCollection 2017.

Reference Type BACKGROUND
PMID: 28749985 (View on PubMed)

Horta D, Lira A, Sanchez-Lloansi M, Villoria A, Teggiachi M, Garcia-Rojo D, Garcia-Molina S, Figuerola A, Esteve M, Calvet X. A Prospective Pilot Randomized Study: Electroacupuncture vs. Sham Procedure for the Treatment of Fatigue in Patients With Quiescent Inflammatory Bowel Disease. Inflamm Bowel Dis. 2020 Feb 11;26(3):484-492. doi: 10.1093/ibd/izz091.

Reference Type BACKGROUND
PMID: 31091322 (View on PubMed)

Other Identifiers

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HMT3

Identifier Type: -

Identifier Source: org_study_id