The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression
NCT ID: NCT04162743
Last Updated: 2020-04-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
22 participants
INTERVENTIONAL
2019-02-01
2020-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
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Trazodone
take trazodone 100mg hs
Trazodone
take trazodone 100mg before polysomnography
Placebo
take placebo pill hs
Placebo oral tablet
take placebo oral tablet before polysomnography
Interventions
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Trazodone
take trazodone 100mg before polysomnography
Placebo oral tablet
take placebo oral tablet before polysomnography
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* overnight mean oxygen saturation (SaO2) nadir is ≤ 70% at baseline
* take monoamine oxidase inhibitors (MAOI), any medication that may affect breathing, sleep, or muscle activity
* any known allergy to trazodone
* sleep disorder other than OSA (e.g., periodic leg movement syndrome, restless legs syndrome, central sleep apnea/Cheyne-Stokes respiration).
20 Years
ALL
No
Sponsors
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Chang Gung Memorial Hospital
OTHER
Responsible Party
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CHEN,CHUNG YAO
doctor
Locations
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Chang Gung Memorial Hospital, Keelung
Keelung, , Taiwan
Countries
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References
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Chen CY, Chen CL, Yu CC. Trazodone improves obstructive sleep apnea after ischemic stroke: a randomized, double-blind, placebo-controlled, crossover pilot study. J Neurol. 2021 Aug;268(8):2951-2960. doi: 10.1007/s00415-021-10480-2. Epub 2021 Feb 24.
Other Identifiers
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CMRPG2I0021
Identifier Type: -
Identifier Source: org_study_id
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