Intestinal Microbiota and Chronic Fatigue Syndrome

NCT ID: NCT04158427

Last Updated: 2022-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-01

Study Completion Date

2022-03-31

Brief Summary

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Gut microbiota of 1) patients with chronic fatigue syndrome and 2) their healthy family members are analyzed.

Up to 40 patients with chronic fatigue syndrome are randomized to receive either 1) a faecal transplant from a healthty donor or 2) their own feces via colonoscopy. Patient's health related quality and ability to work are assessed (baseline, 1 and 6 months after the procedure)

Detailed Description

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Patients with chronic fatigue syndrome (CFS) and their healthy family members (living together in the same house) are recruited in the study. CFS has been diagnosed in Tampere University Hospital and the diagnosis is based on thorough clinical assessment fulfilling the Institute of Medicine 2015 criteria. Patients microbiota is analyzed (microbiological analysis, mediators of inflammation) and results are compared with their family members.

Via colonoscopy, up to 40 patients with CFS are randomized to receive either a faecal transplant from a healthy donor (treatment group) or his/her own feces (placebo group). Products are blinded, investigators and patients are blinded. Patients' health related quality of life and ability to work or study are assessed (baseline, 1 and 6 months after the procedure).

Conditions

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Fatigue Syndrome, Chronic Microbial Colonization

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Double-blinded study, treatment group and placebo-group
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Blinded products, investigators and patients are blinded. Fecal transplant is either from a healthy donor or patient's own feces

Study Groups

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Fecal transplant

A single dose fecal transplant is given (via colonoscopy) from a healthy donor

Group Type EXPERIMENTAL

Faecal transplantation

Intervention Type PROCEDURE

Faecal transplantation from a healthy donor via colonoscopy

Placebo

A single dose patient's own feces is given (via colonoscopy)

Group Type PLACEBO_COMPARATOR

Placebo faecal transplantation

Intervention Type PROCEDURE

Placebo faecal transplantation containing patient's own feces via colonoscopy

Interventions

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Faecal transplantation

Faecal transplantation from a healthy donor via colonoscopy

Intervention Type PROCEDURE

Placebo faecal transplantation

Placebo faecal transplantation containing patient's own feces via colonoscopy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

-Chronic Fatigue Syndrome

Exclusion Criteria

* Other conditions causing chronic fatigue
* Diseases affecting the intestinal system
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Helsinki

OTHER

Sponsor Role collaborator

Tampere University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Tapani Salonen

Principal Investigator, MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tapani Salonen, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Tampere University Hospital

Locations

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Tampere University Hospital

Tampere, , Finland

Site Status

Countries

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Finland

References

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Salonen T, Jokinen E, Satokari R, Lahtinen P. Randomized, double-blinded, placebo-controlled pilot study: efficacy of faecal microbiota transplantation on chronic fatigue syndrome. J Transl Med. 2023 Jul 29;21(1):513. doi: 10.1186/s12967-023-04227-y.

Reference Type DERIVED
PMID: 37516837 (View on PubMed)

Other Identifiers

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R18006

Identifier Type: -

Identifier Source: org_study_id

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