Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation

NCT ID: NCT04155658

Last Updated: 2020-05-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 55 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-11-25
• Study Completion Date: 2020-04-30

Brief Summary

Double-blind, randomized, 3 group in situ study to assess effect of three toothpastes on enamel remineralization, as measured by change in integrated mineral loss (∆∆Z). The study will examine the efficacy of an experimental sodium monofluorophosphate (SMFP) toothpaste, a standard SMFP toothpaste and a negative control toothpaste with no fluoride.

Detailed Description

Double-blind, randomized, 3 group, in situ enamel remineralisation study. This study will accept up to 60 adult subjects who meet the inclusion/exclusion criteria in anticipation that at least 50 subjects will complete the study. All 60 subjects will have two human enamel specimens (one enamel specimen type C and one enamel specimen type N) placed in their partial denture for analysis by transverse microradiography (TMR) and of those sixty subjects, a subset will have an additional two enamel specimens (type N) placed in their partial denture for TMR measurement. All enamel specimens will have been partially demineralized using lactic acid in the laboratory prior to placement in subjects' dentures.

Subjects will receive a dental prophylaxis at the start of the trial and then brush their teeth with a fluoride-free toothpaste for the following 2 to 3 days. For the washout phase between each crossover period, subjects will return to brushing with their regular toothpaste for 4 to 5 days and then receive a dental prophylaxis and brush their teeth with a fluoride-free toothpaste for the 2 to 3 days before the next test period.

During each test period, subjects will be asked to brush with their allocated toothpaste at home twice daily for 4 weeks taking care to not brush the enamel specimens. The brushing procedure will be performed at home each morning following breakfast and right before going to bed on each evening. Subjects must wear their partial denture for 24 hours a day during the test phase.

At final visit of each test period, subjects will be instructed to brush their teeth with the randomly assigned trial toothpaste. Enamel specimens will be removed from denture and transferred to analyst for laboratory analyses.

Conditions

Enamel Caries

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Experimental SMFP Toothpaste

Toothpaste containing 1450ppm SMFP with additional calcium and phosphate

Group Type: EXPERIMENTAL

Experimental Toothpaste containing 1450ppm SMFP

Intervention Type: OTHER

Experimental Toothpaste containing 1450ppm SMFP

SMFP Toothpaste

Toothpaste containing 1450ppm SMFP

Group Type: ACTIVE_COMPARATOR

Toothpaste containing 1450ppm SMFP

Intervention Type: OTHER

Toothpaste containing 1450ppm SMFP

Negative control toothpaste

Toothpaste with no fluoride

Group Type: PLACEBO_COMPARATOR

Toothpaste with no fluoride

Intervention Type: OTHER

Toothpaste with no fluoride

Interventions

Experimental Toothpaste containing 1450ppm SMFP

Experimental Toothpaste containing 1450ppm SMFP

Intervention Type: OTHER

Toothpaste containing 1450ppm SMFP

Toothpaste containing 1450ppm SMFP

Intervention Type: OTHER

Toothpaste with no fluoride

Toothpaste with no fluoride

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Be wearing a removable mandibular partial denture that fits comfortably enough to wear 24 hours a day and willing to have their partial denture modified to accommodate the enamel test specimens.

2. Have completed and been accepted into the Oral Health Research Institute's screening for partial denture panel (#110007150).

3. Have no current active caries or periodontal disease that may compromise the trial or health of the person. Persons exhibiting localized periodontal conditions who, in the opinion of the trial dentist, will not be negatively affected by participation in intra-oral studies may be accepted. Persons with caries may participate if the carious lesions have been restored prior to beginning the first treatment.

4. Be willing to comply with all subjects' responsibilities (be willing and capable of wearing their removable partial dentures 24 hours per day during the treatment periods, attend appointments, follow brushing instructions, use non zinc adhesive in upper denture only etc.).

5. Have an unstimulated salivary flow rate of at least 0.2 ml per minute as determined by a five-minute salivary flow test at screening and a stimulated salivary flow rate of at least 0.8 ml per minute as determined by a two-minute stimulated (gum base) salivary flow test at screening

Exclusion Criteria

1. Currently pregnant, intending to become pregnant during the trial period or breast-feeding.

2. Have a history of significant adverse effects following use of oral hygiene products such as toothpastes and mouth rinses.

3. Have any allergy to ingredients in the trial toothpaste products.

4. Currently be taking antibiotics or have taken antibiotics in the two weeks prior to the beginning the first treatment.

5. Have factors which could contraindicate their participation, such as any condition requiring the need for antibiotic premedication prior to a dental treatment, a condition requiring the need for long-term antibiotic use, blood thinning medications* that prohibit the safe conduct of a dental cleaning* or previous use of the weight loss medications Fen Phen® or Redux®. *Note: Subjects who are taking blood thinners in which written verification is obtained from their physician indicating their PT/INR levels (anti-coagulation blood levels) are at an acceptable level to avoid serious complications, such as bleeding during dental cleaning, may be accepted into the trial.

6. Currently taking or have ever taken a bisphosphonate drug (i.e. Fosamax®, Actonel®, Boniva®, Reclast®, or Zometa®) for treatment of osteoporosis.

7. Currently taking fluoride supplements, required to use a fluoride mouth rinse or have received a professional fluoride treatment in the two weeks preceding specimen placement.

8. Participation in another clinical trial/study within 30 days preceding the present trial/study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Indiana University

OTHER

Sponsor Role: collaborator

Unilever R&D

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Domenick T Zero, DDS, MS

Role: PRINCIPAL_INVESTIGATOR

Indiana University

Locations

Oral Health Research Institute, Indiana University

Indianapolis, Indiana, United States

Countries

United States

Other Identifiers

ORL-IST-3324

Identifier Type: -

Identifier Source: org_study_id