Restylane-L for Correction of Infraorbital Hollows

NCT ID: NCT04154930

Last Updated: 2023-04-25

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

333 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-11

Study Completion Date

2022-04-06

Brief Summary

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This is a prospective, randomized, evaluator-blinded, no-treatment controlled, parallel group, multi-center US study to evaluate the safety and effectiveness of Restylane-L® for correction of Infraorbital Hollows.

Detailed Description

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Conditions

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Infraorbital Hollows

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Restylane-L Treatment

Restylane-L® injected with optional touch-up at 1 month and optional retreatment at 12 months.

Group Type EXPERIMENTAL

Restylane-L®

Intervention Type DEVICE

Intradermal injection.

No Treatment Control

No treatment control with optional treatment at 12 months.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Restylane-L®

Intradermal injection.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Moderate or severe infraorbital hollows with no more than one grade difference between the left and right side at baseline as assessed by the blinded evaluator.
* Males or non-pregnant, non-breastfeeding females, over the age of 21.
* Intent to undergo correction of both orbital hollows.

Exclusion Criteria

* Known/previous allergy or hypersensitivity to any injectable hyaluronic acid (HA) gel or to gram positive bacterial proteins.
* Known/previous allergy or hypersensitivity to local anesthetics, e.g. lidocaine or other amide-type anesthetics.
* Previous deep and/or superficial facial dermal therapies.
* Active or a history of recurrent or chronic infraorbital edema or rosacea or uncontrolled severe seasonal allergies.
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Galderma R&D

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Galderma Research Site

Encino, California, United States

Site Status

Galderma Research Site

Los Angeles, California, United States

Site Status

Galderma Research Site

Redondo Beach, California, United States

Site Status

Galderma Research Site

Solana Beach, California, United States

Site Status

Galderma Research Site

Westport, Connecticut, United States

Site Status

Galderma Research Site

Boynton Beach, Florida, United States

Site Status

Galderma Research Site

Coral Gables, Florida, United States

Site Status

Galderma Research Site

West Palm Beach, Florida, United States

Site Status

Galderma Research Site

Chicago, Illinois, United States

Site Status

Galderma Research Site

Chestnut Hill, Massachusetts, United States

Site Status

Galderma Research Site

New York, New York, United States

Site Status

Galderma Research Site

New York, New York, United States

Site Status

Galderma Research Site

Rochester, New York, United States

Site Status

Galderma Research Site

Wilmington, North Carolina, United States

Site Status

Galderma Research Site

Nashville, Tennessee, United States

Site Status

Galderma Research Site

Spring, Texas, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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43USTT1904

Identifier Type: -

Identifier Source: org_study_id

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