Posturography-Neuropathy

NCT ID: NCT04154540

Last Updated: 2025-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

67 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-19

Study Completion Date

2024-01-19

Brief Summary

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If the classification between hereditary and acquired neuropathy is often easy, there is no completely specific marker allowing the distinction between the two etiologies. Clinical experience suggests that hereditary neuropathies have less impact on balance and gait than the acquired neuropathies at equivalent level of impairment, but this has never been clearly demonstrated.

Detailed Description

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Conditions

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Neuropathy Demyelinating

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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demyelinating hereditary neuropathy

adult patients with demyelinating hereditary neuropathy type CMT 1A.

Group Type EXPERIMENTAL

Motion analysis

Intervention Type OTHER

Gait and posture recording

demyelinating inflammatory neuropathy

adult patients with acquired demyelinating inflammatory neuropathy.

Group Type EXPERIMENTAL

Motion analysis

Intervention Type OTHER

Gait and posture recording

Interventions

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Motion analysis

Gait and posture recording

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* CMT1A for molecular-proven Group 1 (PMP22 duplication)
* IPDC likely or defined for Group 2
* Able to walk 10 m unassisted

Exclusion Criteria

* Neurological history other than neuropathy: epilepsy, stroke, dementia
* Pregnant women
* Person under guardianship or trusteeship
* Musculoskeletal conditions other than neuropathy impairing walking abilities
* Major comorbidity considered a contraindication by the investigator (cancer, unstable angor, etc.)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Céline TARD, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

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Hôpital Roger Salengro, CHU

Lille, , France

Site Status

Countries

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France

References

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Dupont L, Defebvre L, Davion JB, Delval A, Tard C. Postural balance and visual dependence in patients with demyelinating neuropathies differ between acquired and hereditary etiologies. Rev Neurol (Paris). 2025 Jan-Feb;181(1-2):98-105. doi: 10.1016/j.neurol.2024.10.002. Epub 2024 Oct 28.

Reference Type RESULT
PMID: 39462724 (View on PubMed)

Other Identifiers

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2017-A02861-52

Identifier Type: OTHER

Identifier Source: secondary_id

2017_17

Identifier Type: -

Identifier Source: org_study_id

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