The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease
NCT ID: NCT04149093
Last Updated: 2021-03-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2020-05-01
2021-12-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Interventions
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Calretinin staining
A paraffin-embedded hematoxylinphloxin-safran sections will be performed on tissue specimens of proximal resection margins to evaluate the presence or absence of ganglion cells.
Immunohistochemistry (IHC) will then be done on paraffin-embedded sections for calretinin staining.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Long-segment Hirschsprung disease (type A and B)
* Total colonic aganglionosis (TCA)
* Surgery at CHUSJ
* Tissue blocks of proximal resection margin available for pathological analysis
* Minimum 1 month of postoperative follow-up
Exclusion Criteria
* Total colonic with small bowel aganglionosis (TCSA)
* Surgery done at another institution
* Early deaths
* Lost to follow-up
* No documented post-operative outcome
0 Years
18 Months
ALL
No
Sponsors
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St. Justine's Hospital
OTHER
Responsible Party
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Nelson Piche
Principal Investigator
Locations
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CHU Sainte-Justine
Montreal, Quebec, Canada
Countries
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Facility Contacts
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Other Identifiers
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2020-2597
Identifier Type: -
Identifier Source: org_study_id
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