The Effect of Manipulating Hydration Status During Cycling in the Heat on Acute Kidney Injury Biomarkers

NCT ID: NCT04140045

Last Updated: 2020-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-28

Study Completion Date

2020-03-17

Brief Summary

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Acute Kidney Injury (AKI) is common in prolonged endurance events. Risk factors for exercise-associated AKI include: the exercise itself, heat, hypohydration, muscle breakdown and non-steroidal anti-inflammatory drug (NSAID) use. Prior research from our laboratory showed the hypohydration during high-intensity running increased a biomarker of AKI (urine osmolality-corrected kidney injury molecule 1). Therefore, the current study will now investigate the effect of manipulating hydration status during cycling on biomarkers of AKI.

Detailed Description

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Conditions

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Hypohydrated Euhydrated

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Hypohydrated

Participants will be required to restrict their water intake during cycling in the heat (90-120 minutes at 35°C), in order to achieve a body mass loss of approximately 3%.

Group Type EXPERIMENTAL

Water intake

Intervention Type OTHER

Water intake will be manipulated in both arms to create a hypohydrated state and a euhydrated state, post-exercise

Euhydrated

Participants will be provided with water intake that matches their sweat losses during cycling in the heat (90-120 minutes at 35°C)

Group Type EXPERIMENTAL

Water intake

Intervention Type OTHER

Water intake will be manipulated in both arms to create a hypohydrated state and a euhydrated state, post-exercise

Interventions

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Water intake

Water intake will be manipulated in both arms to create a hypohydrated state and a euhydrated state, post-exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy
* recreationally active

Exclusion Criteria

* Smoker/vaper
* regular use of anti-inflammatory medications (e.g. ibuprofen)
* history of kidney disease or diabetes
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Loughborough University

OTHER

Sponsor Role lead

Responsible Party

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Loris Juett

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Loughborough University

Loughborough, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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R19-P130

Identifier Type: -

Identifier Source: org_study_id

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