Trial Outcomes & Findings for Digital Health Interventions for Obsessive Compulsive Disorder (OCD) (NCT NCT04136626)

Last Updated: 2024-11-25

Results Overview

Symptom severity for OCD was measured with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the gold-standard, semi-structured clinician-administered assessment of OCD severity. It contains 10 items ranging from 0 to 4, which are summed to generate a total score (range 0 to 40). Higher scores indicate more severe OCD symptoms.

Recruitment status

COMPLETED

Study phase

Target enrollment

120 participants

Primary outcome timeframe

Baseline (week 0), mid-treatment (week 6), end-of-treatment (week 12)

Results posted on

2024-11-25

Participant Flow

Participant milestones

Participant milestones
Measure	Perspectives OCD 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.
Treatment Phase STARTED	60	60
Treatment Phase COMPLETED	57	46
Treatment Phase NOT COMPLETED	3	14
12-month Follow-up STARTED	57	46
12-month Follow-up 3-month Follow-up	52	41
12-month Follow-up COMPLETED	49	39
12-month Follow-up NOT COMPLETED	8	7

Reasons for withdrawal

Reasons for withdrawal
Measure	Perspectives OCD 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.
Treatment Phase Withdrawal by Subject	1	9
Treatment Phase Adverse Event	1	0
Treatment Phase Lost to Follow-up	1	5
12-month Follow-up Lost to Follow-up	8	7

Baseline Characteristics

One participant in the Health and Well-Being Program group did not provide data for sex at birth.

Baseline characteristics by cohort

PRIMARY outcome

Timeframe: Baseline (week 0), mid-treatment (week 6), end-of-treatment (week 12)

Population: Intent-to-treat analysis, which included all participants randomized to each treatment arm. Some participants dropped out prior to completion of the mid-treatment (week 6) or end-of-treatment (week 12) assessments.

Outcome measures

Outcome measures
Measure	Perspectives OCD n=60 Participants 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program n=60 Participants 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.
Difference in OCD Symptom Severity at the End of Week 12 Week 0	25.12 score on a scale Standard Deviation 4.22	23.77 score on a scale Standard Deviation 4.60
Difference in OCD Symptom Severity at the End of Week 12 Week 6	18.68 score on a scale Standard Deviation 5.34	20.49 score on a scale Standard Deviation 5.32
Difference in OCD Symptom Severity at the End of Week 12 Week 12	16.14 score on a scale Standard Deviation 6.48	18.15 score on a scale Standard Deviation 5.67

SECONDARY outcome

Timeframe: Baseline (week 0), mid-treatment (week 6), end-of-treatment (week 12)

Population: This was an intent-to-treat analysis, which included all participants randomized to each treatment arm. Some participants dropped out prior to completion of the mid-treatment (week 6) or end-of-treatment (week 12) assessments (see participant flow chart); a few more did not complete self-rated questionnaires after completing clinician-rated assessments (Perspectives OCD: n=1 at week 6, n=4 at week 12; Health and Well-Being Program: n=2 at week 6, n=2 at week 12).

The Quick Inventory of Depressive Symptomatology (Self-report; QIDS-SR) is a self-report measure of depressive symptoms consisting of 16 scale items with responses ranging from 0 to 3, including one suicide item (item #12). Total scores range from 0 to 27 with higher scores indicating greater depression severity. The measure is a well-validated, sensitive measure of symptom severity in depression.

Outcome measures

Outcome measures
Measure	Perspectives OCD n=60 Participants 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program n=60 Participants 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.
Difference in Depression at the End of Week 12 Week 0	8.70 score on a scale Standard Deviation 4.53	8.27 score on a scale Standard Deviation 4.11
Difference in Depression at the End of Week 12 Week 6	7.23 score on a scale Standard Deviation 5.10	7.00 score on a scale Standard Deviation 4.20
Difference in Depression at the End of Week 12 Week 12	6.36 score on a scale Standard Deviation 4.60	6.84 score on a scale Standard Deviation 4.89

SECONDARY outcome

Timeframe: Week 0, Week 6, and Week 12

Functional impairment was assessed using the Work and Social Adjustment Scale (WSAS). This scale uses a Likert scale from 0 (not at all) to 10 (extremely) to assess impairment in a person's ability to function in terms of work, home management, leisure activities. Total scores total range from 0-40, where higher scores indicate greater impairment.

Outcome measures

Outcome measures
Measure	Perspectives OCD n=60 Participants 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program n=60 Participants 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.
Difference in Functional Impairment at the End of Week 12 Week 0	20.57 score on a scale Standard Deviation 8.91	18.80 score on a scale Standard Deviation 7.70
Difference in Functional Impairment at the End of Week 12 Week 6	16.04 score on a scale Standard Deviation 9.07	16.43 score on a scale Standard Deviation 10.84
Difference in Functional Impairment at the End of Week 12 Week 12	12.38 score on a scale Standard Deviation 8.99	14.98 score on a scale Standard Deviation 9.97

SECONDARY outcome

Timeframe: Week 0, Week 6, and Week 12

The Quality of Life Enjoyment and Satisfaction Questionnaire Short Form (Q-LES-Q-SF) is a self-report measure of subjective quality of life, containing Likert items ranging from 1 (Very Poor) to 5 (Very Good). Total scores are presented as a percentage of the maximum value (i.e., ranging from 0 to 100), with higher scores indicating greater quality of life).

Outcome measures

Outcome measures
Measure	Perspectives OCD n=60 Participants 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program n=60 Participants 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.
Difference in Quality of Life at the End of Week 12 Week 6	62.93 percentage of the scale maximum score Standard Deviation 15.79	62.54 percentage of the scale maximum score Standard Deviation 16.26
Difference in Quality of Life at the End of Week 12 Week 0	56.63 percentage of the scale maximum score Standard Deviation 15.12	59.02 percentage of the scale maximum score Standard Deviation 14.79
Difference in Quality of Life at the End of Week 12 Week 12	66.87 percentage of the scale maximum score Standard Deviation 16.82	63.04 percentage of the scale maximum score Standard Deviation 16.26

Adverse Events

Perspectives OCD

Serious events: 1 serious events

Other events: 23 other events

Deaths: 0 deaths

The Health and Well-Being Program

Serious events: 0 serious events

Other events: 27 other events

Deaths: 0 deaths

Serious adverse events

Serious adverse events
Measure	Perspectives OCD n=60 participants at risk 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program n=60 participants at risk 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.
Psychiatric disorders Worsening of mental health resulting in inpatient hospitalization	1.7% 1/60 • Number of events 1 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.	0.00% 0/60 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.

Other adverse events

Other adverse events
Measure	Perspectives OCD n=60 participants at risk 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program n=60 participants at risk 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.
Gastrointestinal disorders Gastrointestinal problems including diarrhea, norovirus, Crohn's disease, acid reflux	6.7% 4/60 • Number of events 5 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.	1.7% 1/60 • Number of events 1 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.
Infections and infestations COVID-19 and/or flu	3.3% 2/60 • Number of events 2 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.	10.0% 6/60 • Number of events 6 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.
Musculoskeletal and connective tissue disorders arthritis, leg/foot pain, muscle spasms, muscle tension, herniated disc, tendonitis	3.3% 2/60 • Number of events 2 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.	10.0% 6/60 • Number of events 6 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.
Psychiatric disorders increased depression, anxiety, and/or irritability	8.3% 5/60 • Number of events 5 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.	10.0% 6/60 • Number of events 7 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.
Psychiatric disorders worsening of OCD symptoms	3.3% 2/60 • Number of events 2 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.	6.7% 4/60 • Number of events 4 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.
Social circumstances stress and anxiety due to job, relationships, death of a loved one, or household problems	16.7% 10/60 • Number of events 11 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.	11.7% 7/60 • Number of events 10 • Adverse event data was collected every 6 weeks after the baseline visit, during the mid-treatment assessment visit (week 6) and the post-treatment visit (week 12). At these assessments, participants were probed for adverse events that occurred since the last adverse event assessment (usually 6 weeks prior). Participants were asked 4 questions about: (1) any major physical health problems or major physical injuries; (2) seeing a physical health or mental health provider for any reason; (3) any hospitalizations; or (4) any other major problems or concerns, all pertaining to the time since they were assessed last. Any "yes" resulted in further inquiries into specific adverse events.

Additional Information

Dr. Sabine Wilhelm, Chief of Psychology

Massachusetts General Hospital

Phone: 617-724-6146

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place

Measure	Perspectives OCD n=60 Participants 12 week Smartphone-delivered CBT for OCD. Perspectives OCD: The app-delivered CBT in this project includes modules such as cognitive skills (e.g., cognitive restructuring, core belief work) and behavioral skills (e.g., exposure and response prevention).	The Health and Well-Being Program n=60 Participants 12 week health and well-being education The Health and Well-Being Program: The website includes 12 modules related to general health and well-being (e.g., sleep and nutrition). Each module contains educational information and questions about an indvidual's experience with the given topic.	Total n=120 Participants Total of all reporting groups
Age, Continuous	39.0 years STANDARD_DEVIATION 14.7 • n=60 Participants	41.1 years STANDARD_DEVIATION 15.6 • n=60 Participants	40.1 years STANDARD_DEVIATION 15.1 • n=120 Participants
Sex/Gender, Customized Woman	47 Participants n=60 Participants	46 Participants n=60 Participants	93 Participants n=120 Participants
Sex/Gender, Customized Man	10 Participants n=60 Participants	11 Participants n=60 Participants	21 Participants n=120 Participants
Sex/Gender, Customized Transgender, non-binary, or questioning	3 Participants n=60 Participants	3 Participants n=60 Participants	6 Participants n=120 Participants
Sex: Female, Male Female	50 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for sex at birth.	48 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for sex at birth.	98 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for sex at birth.
Sex: Female, Male Male	10 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for sex at birth.	11 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for sex at birth.	21 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for sex at birth.
Ethnicity (NIH/OMB) Hispanic or Latino	3 Participants n=60 Participants	8 Participants n=60 Participants	11 Participants n=120 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	57 Participants n=60 Participants	52 Participants n=60 Participants	109 Participants n=120 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=60 Participants	0 Participants n=60 Participants	0 Participants n=120 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=60 Participants	1 Participants n=60 Participants	1 Participants n=120 Participants
Race (NIH/OMB) Asian	2 Participants n=60 Participants	4 Participants n=60 Participants	6 Participants n=120 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=60 Participants	1 Participants n=60 Participants	1 Participants n=120 Participants
Race (NIH/OMB) Black or African American	4 Participants n=60 Participants	3 Participants n=60 Participants	7 Participants n=120 Participants
Race (NIH/OMB) White	48 Participants n=60 Participants	44 Participants n=60 Participants	92 Participants n=120 Participants
Race (NIH/OMB) More than one race	4 Participants n=60 Participants	4 Participants n=60 Participants	8 Participants n=120 Participants
Race (NIH/OMB) Unknown or Not Reported	2 Participants n=60 Participants	3 Participants n=60 Participants	5 Participants n=120 Participants
Region of Enrollment United States	60 participants n=60 Participants	60 participants n=60 Participants	120 participants n=120 Participants
Education High school graduate or less	8 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for education.	5 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for education.	13 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for education.
Education Technical school / some college	16 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for education.	11 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for education.	27 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for education.
Education College graduate	21 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for education.	15 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for education.	36 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for education.
Education Graduate or professional school	15 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for education.	28 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for education.	43 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for education.
Marital status Single, never married	26 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	23 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	49 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.
Marital status Married	23 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	28 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	51 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.
Marital status Partnered	5 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	3 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	8 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.
Marital status Divorced / separated	5 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	5 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	10 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.
Marital status Widowed	1 Participants n=60 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	0 Participants n=59 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.	1 Participants n=119 Participants • One participant in the Health and Well-Being Program group did not provide data for marital status.
Employment Employed full-time (>= 35 hours per week)	27 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	35 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	62 Participants n=118 Participants • One participant in each treatment group did not provide data for employment status.
Employment Employed part-time (< 35 hours per week)	6 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	6 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	12 Participants n=118 Participants • One participant in each treatment group did not provide data for employment status.
Employment Student	6 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	6 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	12 Participants n=118 Participants • One participant in each treatment group did not provide data for employment status.
Employment Unemployed	11 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	5 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	16 Participants n=118 Participants • One participant in each treatment group did not provide data for employment status.
Employment Retired	5 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	2 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	7 Participants n=118 Participants • One participant in each treatment group did not provide data for employment status.
Employment Homemaker	4 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	5 Participants n=59 Participants • One participant in each treatment group did not provide data for employment status.	9 Participants n=118 Participants • One participant in each treatment group did not provide data for employment status.
Household income $34,999 or less	21 Participants n=58 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).	19 Participants n=57 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).	40 Participants n=115 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).
Household income $35,000 - 74,999	13 Participants n=58 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).	21 Participants n=57 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).	34 Participants n=115 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).
Household income $75,000 - 149,999	20 Participants n=58 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).	12 Participants n=57 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).	32 Participants n=115 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).
Household income $150,000 or more	4 Participants n=58 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).	5 Participants n=57 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).	9 Participants n=115 Participants • Five participants did not provide income data (2 in Perspectives OCD, 3 in the Health and Well-Being Program group).
Duration of OCD	23.9 years since onset STANDARD_DEVIATION 15.3 • n=60 Participants	26.5 years since onset STANDARD_DEVIATION 16.4 • n=60 Participants	25.2 years since onset STANDARD_DEVIATION 15.8 • n=120 Participants
Current psychiatric comorbidities Major depression	9 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	8 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	17 Participants n=120 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.
Current psychiatric comorbidities Panic disorder	9 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	1 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	10 Participants n=120 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.
Current psychiatric comorbidities Agoraphobia	3 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	4 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	7 Participants n=120 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.
Current psychiatric comorbidities Social anxiety disorder	7 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	10 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	17 Participants n=120 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.
Current psychiatric comorbidities Alcohol use disorder	2 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	5 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	7 Participants n=120 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.
Current psychiatric comorbidities Binge eating disorder	1 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	2 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	3 Participants n=120 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.
Current psychiatric comorbidities Generalized anxiety disorder	8 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	11 Participants n=59 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	19 Participants n=119 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.
Current psychiatric comorbidities Body dysmorphic disorder	5 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	6 Participants n=60 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.	11 Participants n=120 Participants • The diagnostic designation for generalized anxiety disorder was accidentally not assessed for one participant in the Health and Well-Being Program group.
Number of comorbid axis I disorders None	36 Participants n=60 Participants	33 Participants n=60 Participants	69 Participants n=120 Participants
Number of comorbid axis I disorders 1	12 Participants n=60 Participants	11 Participants n=60 Participants	23 Participants n=120 Participants
Number of comorbid axis I disorders 2	6 Participants n=60 Participants	12 Participants n=60 Participants	18 Participants n=120 Participants
Number of comorbid axis I disorders 3 or more	6 Participants n=60 Participants	4 Participants n=60 Participants	10 Participants n=120 Participants
Current psychotropic medication None	35 Participants n=60 Participants	37 Participants n=60 Participants	72 Participants n=120 Participants
Current psychotropic medication Selective reuptake inhibitor (SRI)	15 Participants n=60 Participants	18 Participants n=60 Participants	33 Participants n=120 Participants
Current psychotropic medication Non-SRI antidepressant	5 Participants n=60 Participants	9 Participants n=60 Participants	14 Participants n=120 Participants
Current psychotropic medication Benzodiazepine	6 Participants n=60 Participants	1 Participants n=60 Participants	7 Participants n=120 Participants
Current psychotropic medication Antipsychotic	1 Participants n=60 Participants	0 Participants n=60 Participants	1 Participants n=120 Participants
Current psychotropic medication Other psychotropic medication	10 Participants n=60 Participants	13 Participants n=60 Participants	23 Participants n=120 Participants