The Relationship Between NK Cell and Graves' Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-15

Study Completion Date

2022-06-30

Brief Summary

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Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function and number in GD patients have been described in the investigators' previous study. It is remain unclear whether the NK cell disfunction is a consequence of GD.Based on the investigators' previous study, the investigators plan to monitor NK cell function in participants in the whole course of disease, analyze the association with relevant factors, such as thyroid function, immune state or treatment,to find out influences of thyroid hormones and thyroid receptor antibody affecting the function of NK cell. The investigators will reveal whether the disfunction of NK cell secondary to GD abnormal thyroid function and/or immune disorders, and realize the mechanics.

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Detailed Description

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Conditions

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Graves Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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New untreated GD patients

Before treatment and application of anti-thyroid drugs (methimazole) or radioactive iodine treatment

No interventions assigned to this group

Healthy control

No thyroid related diseases and other immune diseases

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* New GD patients without any treatment
* Aged of 18 to 75 years old

Exclusion Criteria

* Pregnant or lactating woman;
* Known autoimmune disease;
* Receiving psychotropic or hormonal drugs;
* Taking drugs that affect the body's immune function;
* Obviously poor compliance.

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes