Predicting Outcome Following Standardized Exercise Therapy in Knee Osteoarthritis Patients

NCT ID: NCT04123756

Last Updated: 2024-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-01

Study Completion Date

2020-12-31

Brief Summary

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Pain sensitization has been associated with pain severity in people with knee osteoarthritis (KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients. Mechanistic pain profiling aims to identify the underlying mechanisms in the peripheral and central nervous systems, which are associated to the clinical pain.

In addition, the mechanisms underlying the pain relieving effect of standardized exercise therapy are largely unknown, but it is hypothesized that they are linked to the patient's ability to activate the descending pain inhibitory pathways (conditioned pain modulation, CPM) in the central nervous system. Mechanistic pain profiling including CPM have been used prognostic to identify responders to treatment, but these measures as a prognostic tool for standardized exercise therapy has not been investigated.

The primary aim of this study is to investigate if mechanistic pain profiling alone or in combination with clinical pain measures before standardized exercise therapy can predict the patients' pain reduction following the exercise therapy program

Detailed Description

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Conditions

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Knee Osteoarthritis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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standardized exercise therapy for knee OA patients

Standardized exercise therapy for 6-8 weeks (two times per week).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* The American College of Rheumatology for clinical knee osteoarthritis (excluding radiological OA assessment)

Exclusion Criteria

* Known factors to influence pain and pain sensitization
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aalborg University

OTHER

Sponsor Role lead

Responsible Party

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Kristian Kjær Petersen

Associate Professor, M.Sc., Ph.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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FysioDanmark Aarhus

Aarhus, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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N-20190045

Identifier Type: -

Identifier Source: org_study_id

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