DNA Repair Activity in the Skin of Day and Night Shift Workers
NCT ID: NCT04122456
Last Updated: 2025-02-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
48 participants
INTERVENTIONAL
2022-12-07
2025-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Day Shift Work Schedule
Day shift worker skin biopsies will be exposed to artificial sunlight (ultraviolet B radiation; UVB) at the laboratory.
Ultraviolet B Radiation
One skin punch biopsy will be taken to the laboratory for exposure to ultraviolet B radiation. After 1-hour incubation, the biopsies will be bisected in half.
No Ultraviolet B Radiation
One skin punch biopsy will be taken to the laboratory and will be kept as a non-irradiated control.
Night Shift Work Schedule
Night shift worker skin biopsies will be exposed to artificial sunlight (ultraviolet B radiation; UVB) at the laboratory.
Ultraviolet B Radiation
One skin punch biopsy will be taken to the laboratory for exposure to ultraviolet B radiation. After 1-hour incubation, the biopsies will be bisected in half.
No Ultraviolet B Radiation
One skin punch biopsy will be taken to the laboratory and will be kept as a non-irradiated control.
Interventions
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Ultraviolet B Radiation
One skin punch biopsy will be taken to the laboratory for exposure to ultraviolet B radiation. After 1-hour incubation, the biopsies will be bisected in half.
No Ultraviolet B Radiation
One skin punch biopsy will be taken to the laboratory and will be kept as a non-irradiated control.
Eligibility Criteria
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Inclusion Criteria
* Fair skin (Fitzpatrick types I and II)
* Age 18 to 40
* Able to comprehend procedures/risks
* Primarily work and are awake during normal daylight hours (6 am to 6 pm), or primarily work and are awake during night shifts hours (between the hours of 6 pm and 6 am) or may work a mixture of these shifts over the past 3 months. Rotating shifts will be categorized based on the majority of hours worked on average during the last 3 months. Able to fill out a 3-month calendar of work schedule.
Exclusion Criteria
* Currently on photosensitizing medications
* Diabetes Mellitus
* On any hormonal agents (e.g., birth control pills)
* History of abnormal scarring
* History of skin infections
* History of skin cancers
* History of sleep disorders such as sleep apnea or insomnia
* Known allergy to lidocaine local anesthetic
* Pregnancy or nursing
* Other serious health issues
18 Years
40 Years
ALL
Yes
Sponsors
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Wright State University
OTHER
Responsible Party
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Principal Investigators
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Jeffrey B Travers, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Wright State University
Locations
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Wright State Physicians
Fairborn, Ohio, United States
Countries
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Central Contacts
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Facility Contacts
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Pharmacology Translational Unit
Role: primary
Provided Documents
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Document Type: Informed Consent Form
Other Identifiers
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06753
Identifier Type: -
Identifier Source: org_study_id
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