Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
28 participants
OBSERVATIONAL
2016-06-01
2018-10-31
Brief Summary
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Detailed Description
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Methods : Patients were included during the first consultation, UR was performed with RGA in day hospital performed in two institutions, the Charcot clinic and the polyclinic of Beaujolais.
Starting with 1 gram (g) of food, then by regularly doubling dose from 2g to 128g, to reach a 255g cumulative dose in a 3 hour period.
During the the post hospitalization period, patients back home had to eat ½ RGA a day during one month, then 1 RGA a day during one month, together with other rosacea fruits resumption at the end of the 5th week if UR were performed between April 15th and July 15th. A synthesis consultation was made at two months and a telephone interview at one year.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Allergic patients to raw apple and birch
Single-group studies about 28 patients allergic to birch and no longer eating raw rosaceae for at least 6 months. Patients brought back into contact with this family of fruits via the raw golden apple according to an Ultra-Rush protocol.
RAAP - for Raw Apple in connection with re-contact with the raw apple according to an Ultra-Rush protocol
Interventions
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RAAP - for Raw Apple in connection with re-contact with the raw apple according to an Ultra-Rush protocol
Eligibility Criteria
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Inclusion Criteria
* With allergic rhinitis or asthma due to betulaceae pollen (SPT+ and/or IgE + to Bet v 1 \> 0,10 kUA/L)
* With reduced quality of life
Exclusion Criteria
* Pregnant woman
* Uncontrolled asthma (FEV1 \< 70%)
* Immunosuppressed patient or having malignant disease, current infectious disease, or serious cardiovascular disease
* Opposed to use data
10 Years
ALL
No
Sponsors
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Polyclinique du Beaujolais
UNKNOWN
Clinique Charcot
UNKNOWN
Michel Bouvier
NETWORK
Responsible Party
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Michel Bouvier
Principal Investigator
Principal Investigators
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Bouvier Michel, MD
Role: PRINCIPAL_INVESTIGATOR
Centre d' Allergologie du Beaujolais
References
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Nucera E, Aruanno A, Lombardo C, Patriarca G, Schiavino D. Apple desensitization in two patients with PR-10 proteins allergy. Allergy. 2010 Aug;65(8):1060-1. doi: 10.1111/j.1398-9995.2009.02275.x. Epub 2009 Dec 3. No abstract available.
Kopac P, Rudin M, Gentinetta T, Gerber R, Pichler Ch, Hausmann O, Schnyder B, Pichler WJ. Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. Allergy. 2012 Feb;67(2):280-5. doi: 10.1111/j.1398-9995.2011.02744.x. Epub 2011 Nov 10.
Werfel T, Asero R, Ballmer-Weber BK, Beyer K, Enrique E, Knulst AC, Mari A, Muraro A, Ollert M, Poulsen LK, Vieths S, Worm M, Hoffmann-Sommergruber K. Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens. Allergy. 2015 Sep;70(9):1079-90. doi: 10.1111/all.12666. Epub 2015 Jul 7.
Bouvier M; Van der Brempt X; Nosbaum A; Cordier JM; Nicolas JF; Berard F. Induction of oral tolerance in allergy to rosaceae. Revue Française d'Allergologie (54): 127-133, 2014
Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, Fernandez Rivas M, Halken S, Hickstein L, Host A, Knol E, Lack G, Marchisotto MJ, Niggemann B, Nwaru BI, Papadopoulos NG, Poulsen LK, Santos AF, Skypala I, Schoepfer A, Van Ree R, Venter C, Worm M, Vlieg-Boerstra B, Panesar S, de Silva D, Soares-Weiser K, Sheikh A, Ballmer-Weber BK, Nilsson C, de Jong NW, Akdis CA; EAACI Food Allergy and Anaphylaxis Guidelines Group. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014 Aug;69(8):1008-25. doi: 10.1111/all.12429. Epub 2014 Jun 9.
Mauro M, Russello M, Incorvaia C, Gazzola G, Frati F, Moingeon P, Passalacqua G. Birch-apple syndrome treated with birch pollen immunotherapy. Int Arch Allergy Immunol. 2011;156(4):416-22. doi: 10.1159/000323909. Epub 2011 Aug 10.
Incorvaia C, Ridolo E, Mauro M, Russello M, Pastorello E. Allergen immunotherapy for birch-apple syndrome: what do we know? Immunotherapy. 2017 Nov;9(15):1271-1278. doi: 10.2217/imt-2017-0040.
Hansen KS, Khinchi MS, Skov PS, Bindslev-Jensen C, Poulsen LK, Malling HJ. Food allergy to apple and specific immunotherapy with birch pollen. Mol Nutr Food Res. 2004 Nov;48(6):441-8. doi: 10.1002/mnfr.200400037.
Kinaciyan T, Jahn-Schmid B, Radakovics A, Zwolfer B, Schreiber C, Francis JN, Ebner C, Bohle B. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1. J Allergy Clin Immunol. 2007 Apr;119(4):937-43. doi: 10.1016/j.jaci.2006.11.010. Epub 2007 Jan 3.
Scala E, Abeni D, Guerra EC, Locanto M, Pirrotta L, Meneguzzi G, Giani M, Asero R. Cosensitization to profilin is associated with less severe reactions to foods in nsLTPs and storage proteins reactors and with less severe respiratory allergy. Allergy. 2018 Sep;73(9):1921-1923. doi: 10.1111/all.13501. Epub 2018 Jun 22. No abstract available.
Other Identifiers
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Apple CAB 1 - 2019
Identifier Type: -
Identifier Source: org_study_id
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